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Title:
Sun exposure and non-melanocytic skin cancer | Cancer Causes & Control
Description:
Non-melanocytic skin cancer has long been regarded as one of the harmful effects of solar ultraviolet (UV) radiation on human health. In this review, we examine epidemiologic evidence linking sun exposure and skin cancer coming from both descriptive studies in populations and analytical studies involving estimates of exposure in individuals. Particular attention is given to the quality of the published data. The epidemiologic evidence that sun exposure causes skin cancer is mainly indirect. Incidence or mortality is inversely related to latitude in populations of mainly European origin (e.g., the United States, Australia), and is higher in people born in Australia (high ambient solar radiation) than in migrants to Australia from the United Kingdom (lower ambient radiation). Skin cancer occurs mainly at sun-exposed body sites and in people who are sensitive to the sun; a reduced capacity to repair UV-induced DNA damage appears to increase the risk. The direct evidence linking sun exposure and skin cancer is weaker with few well-conducted studies of sun exposure in individuals. Mostly, studies of total sun exposure have not found statistically significant positive associations; those that did, had not adjusted for potential confounding by age and gender and thus their interpretation is limited. Studies of occupational sun exposure had relative risks not greater than 2.0; recreational exposure has been little studied. Other measurements, less direct but potentially less prone to measurement error, are sunburn (not evidently associated with skin cancer risk) and indicators of benign cutaneous sun-damage (strongly associated but lacking empirical evidence that sun exposure is their main cause). Many questions remain about the relationship between sun exposure and skin cancer.Cancer Causes and Control 1994, 5, 367โ392
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Keywords {๐}
google, scholar, cancer, skin, pubmed, dermatol, exposure, incidence, cell, australia, nonmelanoma, sun, radiation, melanoma, iarc, armstrong, risk, basal, carcinoma, epidemiology, med, solar, ultraviolet, united, factors, sci, article, health, aust, research, nonmelanocytic, cutaneous, marks, lyon, france, squamous, urbach, effects, studies, relationship, malignant, scotto, edscancer, volume, kricker, mortality, pub, acad, sunlight, green,
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month download article/chapter sun-exposed body sites amunicipality-based ecological analysis cancer-registry-based surveillance benign cutaneous sun-damage international research programme victoriaโclinical studies ii privacy choices/manage cookies artemis publishing consultants epidemiology research corporation high-risk australian population basal cell carcinoma basal-cell carcinoma registry-based study squamous cell carcinoma molecular epidemiology study descriptive epidemiology malignant cutaneous lesions cutaneous malignant melanoma lacking empirical evidence o'rourke mge total sun exposure occupational sun exposure full article pdf basal-cell epithelioma basal cell epithelioma total accumulated exposure personal exposure model squamous cell cancer facial skin exposure actinic skin damage population-based study cutaneous risk factors fundamental cancer research lower ambient radiation related subjects fraumeni jf jr van der heijden verhagen-teulings mt 24th annual symposium field-test validation sister chromatid exchanges sunlight-induced cancer comparative epidemiological study naeviโatwin study nonmelanoma skin cancer skin cancer morbidity tanzanian albino skin acquired melanocytic nevi conditions privacy policy
Questions {โ}
- Epidemiology of malignant melanoma: intermittent or total accumulated exposure to the sun?
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headline:Sun exposure and non-melanocytic skin cancer
description:Non-melanocytic skin cancer has long been regarded as one of the harmful effects of solar ultraviolet (UV) radiation on human health. In this review, we examine epidemiologic evidence linking sun exposure and skin cancer coming from both descriptive studies in populations and analytical studies involving estimates of exposure in individuals. Particular attention is given to the quality of the published data. The epidemiologic evidence that sun exposure causes skin cancer is mainly indirect. Incidence or mortality is inversely related to latitude in populations of mainly European origin (e.g., the United States, Australia), and is higher in people born in Australia (high ambient solar radiation) than in migrants to Australia from the United Kingdom (lower ambient radiation). Skin cancer occurs mainly at sun-exposed body sites and in people who are sensitive to the sun; a reduced capacity to repair UV-induced DNA damage appears to increase the risk. The direct evidence linking sun exposure and skin cancer is weaker with few well-conducted studies of sun exposure in individuals. Mostly, studies of total sun exposure have not found statistically significant positive associations; those that did, had not adjusted for potential confounding by age and gender and thus their interpretation is limited. Studies of occupational sun exposure had relative risks not greater than 2.0; recreational exposure has been little studied. Other measurements, less direct but potentially less prone to measurement error, are sunburn (not evidently associated with skin cancer risk) and indicators of benign cutaneous sun-damage (strongly associated but lacking empirical evidence that sun exposure is their main cause). Many questions remain about the relationship between sun exposure and skin cancer.Cancer Causes and Control 1994, 5, 367โ392
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host factors
skin cancer
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headline:Sun exposure and non-melanocytic skin cancer
description:Non-melanocytic skin cancer has long been regarded as one of the harmful effects of solar ultraviolet (UV) radiation on human health. In this review, we examine epidemiologic evidence linking sun exposure and skin cancer coming from both descriptive studies in populations and analytical studies involving estimates of exposure in individuals. Particular attention is given to the quality of the published data. The epidemiologic evidence that sun exposure causes skin cancer is mainly indirect. Incidence or mortality is inversely related to latitude in populations of mainly European origin (e.g., the United States, Australia), and is higher in people born in Australia (high ambient solar radiation) than in migrants to Australia from the United Kingdom (lower ambient radiation). Skin cancer occurs mainly at sun-exposed body sites and in people who are sensitive to the sun; a reduced capacity to repair UV-induced DNA damage appears to increase the risk. The direct evidence linking sun exposure and skin cancer is weaker with few well-conducted studies of sun exposure in individuals. Mostly, studies of total sun exposure have not found statistically significant positive associations; those that did, had not adjusted for potential confounding by age and gender and thus their interpretation is limited. Studies of occupational sun exposure had relative risks not greater than 2.0; recreational exposure has been little studied. Other measurements, less direct but potentially less prone to measurement error, are sunburn (not evidently associated with skin cancer risk) and indicators of benign cutaneous sun-damage (strongly associated but lacking empirical evidence that sun exposure is their main cause). Many questions remain about the relationship between sun exposure and skin cancer.Cancer Causes and Control 1994, 5, 367โ392
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