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We are analyzing https://www.nature.com/articles/1210392.

Title:
Differential regulation and properties of MAPKs | Oncogene
Description:
Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the cell surface and the metabolic state and environment of the cell. In mammals, there are more than a dozen MAPK genes. The best known are the extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK(1–3)) and p38(Ξ±, Ξ², Ξ³ and Ξ΄) families. ERK3, ERK5 and ERK7 are other MAPKs that have distinct regulation and functions. MAPK cascades consist of a core of three protein kinases. Despite the apparently simple architecture of this pathway, these enzymes are capable of responding to a bewildering number of stimuli to produce exquisitely specific cellular outcomes. These responses depend on the kinetics of their activation and inactivation, the subcellular localization of the kinases, the complexes in which they act, and the availability of substrates. Fine-tuning of cascade activity can occur through modulatory inputs to cascade component from the primary kinases to the scaffolding accessory proteins. Here, we describe some of the properties of the three major MAPK pathways and discuss how these properties govern pathway regulation and activity.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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  • Education
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Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {πŸ”}

pubmed, google, scholar, cas, kinase, protein, biol, cell, erk, central, chem, map, mitogenactivated, activation, kinases, mol, nature, jnk, regulation, signaling, cobb, scaffold, mapk, sci, access, article, nuclear, phosphorylation, regulates, dev, proc, natl, acad, usa, wang, pathway, activity, docking, content, chen, cjun, cascade, pathways, davis, phosphatase, cells, binding, mekk, cookies, oncogene,

Topics {βœ’οΈ}

nature portfolio permissions reprints tissue research privacy policy c-jun n-terminal kinase advertising mitogen-activated protein kinase nature 411 nature 420 nature 372 nature p38 mitogen-activated protein rac-mekk3-mkk3 scaffolding social media stress-activated protein kinase-3 stress-activated protein kinase c-jun-nh2 kinase stress-activated protein kinases c-jun-dependent cell proliferation p38 stress-activated kinase author information authors activates c-jun nh c-myc protein stability regulatory c-terminal sequence extracellular signal-related kinase ras/map kinase signaling uv-responsive protein kinase c-jun activation domain autosomal-dominant polycystic kidneys nf-kappab signalling pathways extracellular signal-regulated kinase author correspondence extracellular signal-regulated kinases nuclear pore complex-mediated personal data springerlink instant access downregulates nf-kappab pathway positive-feedback kinase loop mp1-mapk scaffold complex p38 protein kinases c-jun nh coordinating erk/mapk signalling data protection permissions tpl2/erk-dependent pathway c-jun promoter map kinase cascades map kinase module map kinase kinase protein kinase involved

Schema {πŸ—ΊοΈ}

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         headline:Differential regulation and properties of MAPKs
         description:Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the cell surface and the metabolic state and environment of the cell. In mammals, there are more than a dozen MAPK genes. The best known are the extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK(1Ҁ“3)) and p38(α, β, γ and δ) families. ERK3, ERK5 and ERK7 are other MAPKs that have distinct regulation and functions. MAPK cascades consist of a core of three protein kinases. Despite the apparently simple architecture of this pathway, these enzymes are capable of responding to a bewildering number of stimuli to produce exquisitely specific cellular outcomes. These responses depend on the kinetics of their activation and inactivation, the subcellular localization of the kinases, the complexes in which they act, and the availability of substrates. Fine-tuning of cascade activity can occur through modulatory inputs to cascade component from the primary kinases to the scaffolding accessory proteins. Here, we describe some of the properties of the three major MAPK pathways and discuss how these properties govern pathway regulation and activity.
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      headline:Differential regulation and properties of MAPKs
      description:Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the cell surface and the metabolic state and environment of the cell. In mammals, there are more than a dozen MAPK genes. The best known are the extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK(1Ҁ“3)) and p38(α, β, γ and δ) families. ERK3, ERK5 and ERK7 are other MAPKs that have distinct regulation and functions. MAPK cascades consist of a core of three protein kinases. Despite the apparently simple architecture of this pathway, these enzymes are capable of responding to a bewildering number of stimuli to produce exquisitely specific cellular outcomes. These responses depend on the kinetics of their activation and inactivation, the subcellular localization of the kinases, the complexes in which they act, and the availability of substrates. Fine-tuning of cascade activity can occur through modulatory inputs to cascade component from the primary kinases to the scaffolding accessory proteins. Here, we describe some of the properties of the three major MAPK pathways and discuss how these properties govern pathway regulation and activity.
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