DOI . ORG {}

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We began analyzing https://www.nature.com/articles/1205093, but it redirected us to https://www.nature.com/articles/1205093. The analysis below is for the second page.

Title[redir]:
Id proteins at the cross-road of development and cancer | Oncogene
Description:
A large body of evidence has been accumulated that demonstrates dominant effects of Id proteins on different aspects of cellular growth. Generally, constitutive expression of Id not only blocks cell differentiation but also drives proliferation. In some settings, it is sufficient to render cells immortal or induce oncogenic transformation. The participation of Id proteins in advanced human malignancy, where they are frequently deregulated, has been dramatically bolstered by the recent discovery that Id exert pivotal contributions to many of the essential alterations that collectively dictate malignant growth. Relentless proliferation associated with self-sufficiency in growth signals and insensitivity to growth inhibitory signals, sustained neoangiogenesis, tissue invasiveness and migration capabilities of tumor cells all share dependency on the unlimited availability of Id proteins. It is remarkable that many of these features recapitulate those physiologically propelled by Id proteins to support normal development. We propose that the participation of Id in multiple fundamental traits of cancer may be the basis for unprecedented therapeutic opportunities.

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Science
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Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month

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Keywords {🔍}

cell, nature, biol, cancer, access, res, article, mol, iavarone, israel, norton, content, proteins, lasorella, sci, usa, hara, cookies, oncogene, growth, proc, natl, acad, dev, privacy, development, open, deed, yokota, data, differentiation, chem, benezra, peters, campisi, advertising, information, subscribe, review, antonio, cells, institution, buy, references, hernandez, nat, immunol, christy, biochem, biophys,

Topics {✒️}

nature portfolio permissions reprints privacy policy advertising 2001 nature 411 2000 nature 407 1999 nature 401 2001 nature 409 1999 nature 397 nature social media author information authors nih grant ro1-ca85628 support normal development author correspondence takuma uo & antonio iavarone molecular biology personal data springerlink instant access data protection permissions bone morphogenetic protein immunogenic cell death alani rm important original references privacy heart development blocks cell differentiation explore content subscription content european economic area demonstrates dominant effects induce oncogenic transformation advanced human malignancy multiple fundamental traits unprecedented therapeutic opportunities institutional subscriptions read 1726s–1730s jen albert einstein college nuclear factor nf daniela nasifemanuel campoymaría accepting optional cookies anchorage-independent growth render cells immortal mesenchymal stem cells journals search log kaelin jr wg comprehensive cancer center growth inhibitory signals anti-tumor effects

Questions {❓}

Epigenetic regulation of ID4 in breast cancer: tumor suppressor or oncogene?

Schema {🗺️}

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Social Networks {👍}(1)

https://twitter.com/oncogenejournal

External Links {🔗}(104)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Prism.js
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Emails and Hosting {✉️}

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mx.zoho.eu
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josh.ns.cloudflare.com
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