
NATURE . COM {
}
Title:
Id proteins at the cross-road of development and cancer | Oncogene
Description:
A large body of evidence has been accumulated that demonstrates dominant effects of Id proteins on different aspects of cellular growth. Generally, constitutive expression of Id not only blocks cell differentiation but also drives proliferation. In some settings, it is sufficient to render cells immortal or induce oncogenic transformation. The participation of Id proteins in advanced human malignancy, where they are frequently deregulated, has been dramatically bolstered by the recent discovery that Id exert pivotal contributions to many of the essential alterations that collectively dictate malignant growth. Relentless proliferation associated with self-sufficiency in growth signals and insensitivity to growth inhibitory signals, sustained neoangiogenesis, tissue invasiveness and migration capabilities of tumor cells all share dependency on the unlimited availability of Id proteins. It is remarkable that many of these features recapitulate those physiologically propelled by Id proteins to support normal development. We propose that the participation of Id in multiple fundamental traits of cancer may be the basis for unprecedented therapeutic opportunities.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {๐}
- Science
- Education
- Telecommunications
Content Management System {๐}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {๐}
What is the average monthly size of nature.com audience?
๐ Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,797,153 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {๐ธ}
Display Ads {๐ฏ}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {๐ฐ}
Display Ads {๐ฏ}
$539,300 per month
Our estimates place Nature.com's monthly online earnings from display ads at $359,538 to $988,730.
Keywords {๐}
cell, nature, biol, cancer, access, res, article, mol, iavarone, israel, norton, content, proteins, lasorella, sci, usa, hara, cookies, oncogene, growth, proc, natl, acad, dev, privacy, development, open, deed, yokota, data, differentiation, chem, benezra, peters, campisi, advertising, information, subscribe, review, antonio, cells, institution, buy, references, hernandez, nat, immunol, christy, biochem, biophys,
Topics {โ๏ธ}
nature portfolio permissions reprints privacy policy advertising 2001 nature 411 2000 nature 407 1999 nature 401 2001 nature 409 1999 nature 397 nature social media author information authors nih grant ro1-ca85628 support normal development author correspondence takuma uoย &ย antonio iavarone molecular biology personal data springerlink instant access data protection permissions bone morphogenetic protein immunogenic cell death alani rm important original references privacy heart development blocks cell differentiation explore content subscription content european economic area demonstrates dominant effects induce oncogenic transformation advanced human malignancy multiple fundamental traits unprecedented therapeutic opportunities institutional subscriptions read 1726sโ1730s jen albert einstein college nuclear factor nf daniela nasifemanuel campoymarรญa accepting optional cookies anchorage-independent growth render cells immortal mesenchymal stem cells journals search log kaelin jr wg comprehensive cancer center growth inhibitory signals anti-tumor effects
Questions {โ}
- Epigenetic regulation of ID4 in breast cancer: tumor suppressor or oncogene?
Schema {๐บ๏ธ}
WebPage:
mainEntity:
headline:Id proteins at the cross-road of development and cancer
description:A large body of evidence has been accumulated that demonstrates dominant effects of Id proteins on different aspects of cellular growth. Generally, constitutive expression of Id not only blocks cell differentiation but also drives proliferation. In some settings, it is sufficient to render cells immortal or induce oncogenic transformation. The participation of Id proteins in advanced human malignancy, where they are frequently deregulated, has been dramatically bolstered by the recent discovery that Id exert pivotal contributions to many of the essential alterations that collectively dictate malignant growth. Relentless proliferation associated with self-sufficiency in growth signals and insensitivity to growth inhibitory signals, sustained neoangiogenesis, tissue invasiveness and migration capabilities of tumor cells all share dependency on the unlimited availability of Id proteins. It is remarkable that many of these features recapitulate those physiologically propelled by Id proteins to support normal development. We propose that the participation of Id in multiple fundamental traits of cancer may be the basis for unprecedented therapeutic opportunities.
datePublished:2002-02-05T00:00:00Z
dateModified:2002-02-05T00:00:00Z
pageStart:8326
pageEnd:8333
sameAs:https://doi.org/10.1038/sj.onc.1205093
keywords:
cell differentiation
cell cycle
retinoblastoma protein
Id2
neuroblastoma
angiogenesis
Medicine/Public Health
general
Internal Medicine
Cell Biology
Human Genetics
Oncology
Apoptosis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1205093/MediaObjects/41388_2002_Article_BF1205093_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1205093/MediaObjects/41388_2002_Article_BF1205093_Fig2_HTML.jpg
isPartOf:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:20
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Anna Lasorella
affiliation:
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
type:Organization
type:Person
name:Takuma Uo
affiliation:
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
type:Organization
type:Person
name:Antonio Iavarone
affiliation:
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Id proteins at the cross-road of development and cancer
description:A large body of evidence has been accumulated that demonstrates dominant effects of Id proteins on different aspects of cellular growth. Generally, constitutive expression of Id not only blocks cell differentiation but also drives proliferation. In some settings, it is sufficient to render cells immortal or induce oncogenic transformation. The participation of Id proteins in advanced human malignancy, where they are frequently deregulated, has been dramatically bolstered by the recent discovery that Id exert pivotal contributions to many of the essential alterations that collectively dictate malignant growth. Relentless proliferation associated with self-sufficiency in growth signals and insensitivity to growth inhibitory signals, sustained neoangiogenesis, tissue invasiveness and migration capabilities of tumor cells all share dependency on the unlimited availability of Id proteins. It is remarkable that many of these features recapitulate those physiologically propelled by Id proteins to support normal development. We propose that the participation of Id in multiple fundamental traits of cancer may be the basis for unprecedented therapeutic opportunities.
datePublished:2002-02-05T00:00:00Z
dateModified:2002-02-05T00:00:00Z
pageStart:8326
pageEnd:8333
sameAs:https://doi.org/10.1038/sj.onc.1205093
keywords:
cell differentiation
cell cycle
retinoblastoma protein
Id2
neuroblastoma
angiogenesis
Medicine/Public Health
general
Internal Medicine
Cell Biology
Human Genetics
Oncology
Apoptosis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1205093/MediaObjects/41388_2002_Article_BF1205093_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1205093/MediaObjects/41388_2002_Article_BF1205093_Fig2_HTML.jpg
isPartOf:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:20
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Anna Lasorella
affiliation:
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
type:Organization
type:Person
name:Takuma Uo
affiliation:
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
type:Organization
type:Person
name:Antonio Iavarone
affiliation:
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:20
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Anna Lasorella
affiliation:
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
type:Organization
name:Takuma Uo
affiliation:
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
type:Organization
name:Antonio Iavarone
affiliation:
name:Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine
address:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
name:Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, USA
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {๐}(19)
- Get to know https://link.springer.com/article/10.1038/sj.onc.1205093?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle's earnings
- Get to know what's the income of https://citation-needed.springer.com/v2/references/10.1038/sj.onc.1205093?format=refman&flavour=references
- How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anna%20Lasorella making per month?
- Financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Anna%20Lasorella%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the revenue for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Takuma%20Uo?
- Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Takuma%20Uo%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Get to know https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Antonio%20Iavarone's earnings
- What is the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Antonio%20Iavarone%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the total monthly financial gain of https://s100.copyright.com/AppDispatchServlet?title=Id%20proteins%20at%20the%20cross-road%20of%20development%20and%20cancer&author=Anna%20Lasorella%20et%20al&contentID=10.1038%2Fsj.onc.1205093©right=Macmillan%20Publishers%20Limited&publication=0950-9232&publicationDate=2002-02-05&publisherName=SpringerNature&orderBeanReset=true?
- Get to know https://citation-needed.springer.com/v2/references/10.1038/sj.onc.1205093?format=refman&flavour=citation's earnings
- How much money does https://doi.org/10.1007/s11033-020-06089-9 generate?
- What's the total monthly financial gain of https://doi.org/10.1186/s12964-019-0365-z?
- What's the financial outcome of https://doi.org/10.1186/s12958-019-0476-9?
- What's the financial intake of https://doi.org/10.1038/s41419-019-1738-3?
- How much cash flow does https://doi.org/10.1186/s13148-018-0542-8 have monthly?
- How much does https://www.protocols.io/ earn?
- Explore the financials of https://www.natureindex.com/
- Monthly income for http://www.naturechina.com
- How much profit does https://www.natureasia.com/ja-jp make?
Analytics and Tracking {๐}
- Google Tag Manager
Libraries {๐}
- Prism.js
- Zoom.js
Emails and Hosting {โ๏ธ}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {๐ฆ}
- Crossref