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We are analyzing https://www.nature.com/articles/1205093.

Title:
Id proteins at the cross-road of development and cancer | Oncogene
Description:
A large body of evidence has been accumulated that demonstrates dominant effects of Id proteins on different aspects of cellular growth. Generally, constitutive expression of Id not only blocks cell differentiation but also drives proliferation. In some settings, it is sufficient to render cells immortal or induce oncogenic transformation. The participation of Id proteins in advanced human malignancy, where they are frequently deregulated, has been dramatically bolstered by the recent discovery that Id exert pivotal contributions to many of the essential alterations that collectively dictate malignant growth. Relentless proliferation associated with self-sufficiency in growth signals and insensitivity to growth inhibitory signals, sustained neoangiogenesis, tissue invasiveness and migration capabilities of tumor cells all share dependency on the unlimited availability of Id proteins. It is remarkable that many of these features recapitulate those physiologically propelled by Id proteins to support normal development. We propose that the participation of Id in multiple fundamental traits of cancer may be the basis for unprecedented therapeutic opportunities.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {๐Ÿ“š}

  • Science
  • Education
  • Telecommunications

Content Management System {๐Ÿ“}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {๐Ÿ“ˆ}

What is the average monthly size of nature.com audience?

๐ŸŒ† Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,797,153 visitors per month in the current month.

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How Does Nature.com Make Money? {๐Ÿ’ธ}


Display Ads {๐ŸŽฏ}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {๐Ÿ’ฐ}


Display Ads {๐ŸŽฏ}

$539,300 per month
Our estimates place Nature.com's monthly online earnings from display ads at $359,538 to $988,730.

Keywords {๐Ÿ”}

cell, nature, biol, cancer, access, res, article, mol, iavarone, israel, norton, content, proteins, lasorella, sci, usa, hara, cookies, oncogene, growth, proc, natl, acad, dev, privacy, development, open, deed, yokota, data, differentiation, chem, benezra, peters, campisi, advertising, information, subscribe, review, antonio, cells, institution, buy, references, hernandez, nat, immunol, christy, biochem, biophys,

Topics {โœ’๏ธ}

nature portfolio permissions reprints privacy policy advertising 2001 nature 411 2000 nature 407 1999 nature 401 2001 nature 409 1999 nature 397 nature social media author information authors nih grant ro1-ca85628 support normal development author correspondence takuma uoย &ย antonio iavarone molecular biology personal data springerlink instant access data protection permissions bone morphogenetic protein immunogenic cell death alani rm important original references privacy heart development blocks cell differentiation explore content subscription content european economic area demonstrates dominant effects induce oncogenic transformation advanced human malignancy multiple fundamental traits unprecedented therapeutic opportunities institutional subscriptions read 1726sโ€“1730s jen albert einstein college nuclear factor nf daniela nasifemanuel campoymarรญa accepting optional cookies anchorage-independent growth render cells immortal mesenchymal stem cells journals search log kaelin jr wg comprehensive cancer center growth inhibitory signals anti-tumor effects

Questions {โ“}

  • Epigenetic regulation of ID4 in breast cancer: tumor suppressor or oncogene?

Schema {๐Ÿ—บ๏ธ}

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         description:A large body of evidence has been accumulated that demonstrates dominant effects of Id proteins on different aspects of cellular growth. Generally, constitutive expression of Id not only blocks cell differentiation but also drives proliferation. In some settings, it is sufficient to render cells immortal or induce oncogenic transformation. The participation of Id proteins in advanced human malignancy, where they are frequently deregulated, has been dramatically bolstered by the recent discovery that Id exert pivotal contributions to many of the essential alterations that collectively dictate malignant growth. Relentless proliferation associated with self-sufficiency in growth signals and insensitivity to growth inhibitory signals, sustained neoangiogenesis, tissue invasiveness and migration capabilities of tumor cells all share dependency on the unlimited availability of Id proteins. It is remarkable that many of these features recapitulate those physiologically propelled by Id proteins to support normal development. We propose that the participation of Id in multiple fundamental traits of cancer may be the basis for unprecedented therapeutic opportunities.
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      headline:Id proteins at the cross-road of development and cancer
      description:A large body of evidence has been accumulated that demonstrates dominant effects of Id proteins on different aspects of cellular growth. Generally, constitutive expression of Id not only blocks cell differentiation but also drives proliferation. In some settings, it is sufficient to render cells immortal or induce oncogenic transformation. The participation of Id proteins in advanced human malignancy, where they are frequently deregulated, has been dramatically bolstered by the recent discovery that Id exert pivotal contributions to many of the essential alterations that collectively dictate malignant growth. Relentless proliferation associated with self-sufficiency in growth signals and insensitivity to growth inhibitory signals, sustained neoangiogenesis, tissue invasiveness and migration capabilities of tumor cells all share dependency on the unlimited availability of Id proteins. It is remarkable that many of these features recapitulate those physiologically propelled by Id proteins to support normal development. We propose that the participation of Id in multiple fundamental traits of cancer may be the basis for unprecedented therapeutic opportunities.
      datePublished:2002-02-05T00:00:00Z
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         Cell Biology
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