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We began analyzing https://www.nature.com/articles/1204920, but it redirected us to https://www.nature.com/articles/1204920. The analysis below is for the second page.

Title[redir]:
Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines | Oncogene
Description:
Insulin-like growth factors (IGFs) regulate breast cancer cell proliferation, protect cells from apoptosis, and enhance metastasis. In this study, we examined the IGF signaling pathway in two breast cancer cell lines selected for metastatic behavior. LCC6 was selected for growth as an ascites tumor in athymic mice from parental MDA-MB-435 cells (435P). The MDA-231BO cell line was derived from osseous metastases that formed after intracardiac injection of the MDA-MB-231 cell line in athymic mice. Compared to the parental cell lines, IGF-I treatment enhanced IRS-2 phosphorylation over IRS-1 in the metastatic variants. IGF-I stimulated cell migration in the variant cells, but not in the parental cells. To determine the role for IRS-2 in IGF-mediated motility, we transfected MDA-231BO cells with an anti-sense IRS-2 construct. Transfected cells had decreased levels of IRS-2 with diminished IGF-mediated motility and anchorage independent growth when compared to control cells. However, adherence to fibronectin was enhanced in the transfected cells compared to MDA-231BO cells. Our data show that breast cancer cells selected for metastatic behavior in vivo have increased IRS-2 activation and signaling. In these cells, IGF-I enhances cell adhesion and motility suggesting that IRS-2 may mediate these aspects of the malignant phenotype.

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Keywords {🔍}

cancer, cell, article, breast, nature, cells, biol, irs, yee, access, res, receptor, insulin, google, scholar, content, substrate, jackson, growth, chem, cas, cookies, oncogene, privacy, data, motility, metastatic, yoneda, open, journal, november, lines, insulinlike, parental, igfi, lee, texas, san, antonio, advertising, information, subscribe, variants, james, zhang, douglas, signaling, selected, mdamb, mdabo,

Topics {✒️}

nature portfolio permissions reprints privacy policy nature public health service immune prognostic index advertising social media author information authors glycolysis-related gene signature author correspondence mda-231bo cell line mda-mb-231 cell line diminished igf-mediated motility anti-sense irs-2 construct parental mda-mb-435 cells transfected mda-231bo cells springerlink instant access permissions insulin receptor substrate-2 insulin receptor substrate-1 insulin receptor substrate-4 personal data stimulated cell migration enhances cell adhesion data protection data show parental cell lines high-risk patients mda-231bo cells privacy mda-mb-435 parental issue learn igf-mediated motility breast cancer explore content subscription content drs robert clark anchorage independent growth european economic area institutional subscriptions read le marchand-brustel val toledo-loboluis accepting optional cookies journals search log de frias dv igf signaling pathway converting signaling dynamics growth factors manage preferences

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