
NATURE . COM {
}
Title:
Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16 | Oncogene
Description:
Interferons are important in regulating cell growth and differentiation, immune function and initiating anti-viral responses. While the pleotrophic actions of interferons have been well documented, the molecular mechanisms underpinning their biological effects have not been fully characterized. IFI 16 is a member of the interferon-inducible HIN-200 family of nuclear proteins, which we have recently shown can function as a potent transcriptional repressor. A murine member of the HIN-200 family, p202, can indirectly interact with p53 via the p53 binding protein (p53bp) and inhibit p53-mediated transcriptional activation. The binding activity of p202 to p53bp was shown to require the conserved MFHATVAT motif present in all 200 amino acid repeat regions of HIN-200 proteins. Given that IFI 16 contains two MFHATVAT motifs, we sought to determine whether IFI 16 may form a complex with p53 and if so to ascertain the functional significance of this interaction. We demonstrate that IFI 16 can directly bind to the C-terminal region of p53 and augment p53-mediated transcriptional activation without altering the steady state levels of p53. Thus, in addition to its ability to directly regulate gene expression, IFI 16 can also modulate the transcription function of other cellular transcription factors. These findings demonstrate a possible link between gene induction following interferon stimulation and p53-mediated cellular events.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {π}
- Telecommunications
- Science
- Social Networks
Content Management System {π}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of nature.com audience?
π Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {πΈ}
Display Ads {π―}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {π°}
Display Ads {π―}
$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.
Keywords {π}
cell, nature, biol, oncogene, ifi, trapani, access, article, choubey, lengyel, content, johnstone, research, cookies, chem, res, privacy, open, briggs, biochem, mol, gutterman, embo, wang, function, data, interaction, interferon, datta, dawson, biophys, gariglio, landolfo, cancer, advertising, information, journal, subscribe, december, functional, interferoninducible, wei, greenway, growth, molecular, hin, family, transcriptional, pmediated, activation,
Topics {βοΈ}
nature portfolio permissions reprints privacy policy principal research fellow author information authors 1996 nature 382 1992 nature 357 nature medical research council advertising social media east melbourne medical research p53-mediated cellular events promotes e2-dependent growth initiating anti-viral responses multidrug transporter p-glycoprotein personal data interferon-inducible hin-200 family springerlink instant access data protection cellular transcription factors permissions lee j chromatin-bound ifi16 steady state levels privacy potent transcriptional repressor issue learn mutant p53 cells explore content subscription content european economic area institutional subscriptions read el-deiry ws smorgon family building st andrews place macfarlane burnet centre yarra bend road nutlin-3-induced redistribution accepting optional cookies regulating cell growth p53 binding protein interferon cytokine res molecular mechanisms underpinning molecular life sciences journals search log nuclear proteins c-terminal region woodchuck hepatitis virus
Questions {β}
- The Multidrug Transporter P-Glycoprotein: A Mediator of Melanoma Invasion?
Schema {πΊοΈ}
WebPage:
mainEntity:
headline:Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16
description:Interferons are important in regulating cell growth and differentiation, immune function and initiating anti-viral responses. While the pleotrophic actions of interferons have been well documented, the molecular mechanisms underpinning their biological effects have not been fully characterized. IFI 16 is a member of the interferon-inducible HIN-200 family of nuclear proteins, which we have recently shown can function as a potent transcriptional repressor. A murine member of the HIN-200 family, p202, can indirectly interact with p53 via the p53 binding protein (p53bp) and inhibit p53-mediated transcriptional activation. The binding activity of p202 to p53bp was shown to require the conserved MFHATVAT motif present in all 200 amino acid repeat regions of HIN-200 proteins. Given that IFI 16 contains two MFHATVAT motifs, we sought to determine whether IFI 16 may form a complex with p53 and if so to ascertain the functional significance of this interaction. We demonstrate that IFI 16 can directly bind to the C-terminal region of p53 and augment p53-mediated transcriptional activation without altering the steady state levels of p53. Thus, in addition to its ability to directly regulate gene expression, IFI 16 can also modulate the transcription function of other cellular transcription factors. These findings demonstrate a possible link between gene induction following interferon stimulation and p53-mediated cellular events.
datePublished:2000-12-07T00:00:00Z
dateModified:2000-12-07T00:00:00Z
pageStart:6033
pageEnd:6042
sameAs:https://doi.org/10.1038/sj.onc.1204005
keywords:
transcription
IFI 16
p53
interferon
Medicine/Public Health
general
Internal Medicine
Cell Biology
Human Genetics
Oncology
Apoptosis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1204005/MediaObjects/41388_2000_Article_BF1204005_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1204005/MediaObjects/41388_2000_Article_BF1204005_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1204005/MediaObjects/41388_2000_Article_BF1204005_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1204005/MediaObjects/41388_2000_Article_BF1204005_Fig4_HTML.jpg
isPartOf:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:19
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Ricky W Johnstone
affiliation:
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
type:Organization
type:Person
name:Wu Wei
affiliation:
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
type:Organization
type:Person
name:Alison Greenway
affiliation:
name:The Macfarlane Burnet Centre for Medical Research
address:
name:The Macfarlane Burnet Centre for Medical Research, Fairfield, Australia
type:PostalAddress
type:Organization
type:Person
name:Joseph A Trapani
affiliation:
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16
description:Interferons are important in regulating cell growth and differentiation, immune function and initiating anti-viral responses. While the pleotrophic actions of interferons have been well documented, the molecular mechanisms underpinning their biological effects have not been fully characterized. IFI 16 is a member of the interferon-inducible HIN-200 family of nuclear proteins, which we have recently shown can function as a potent transcriptional repressor. A murine member of the HIN-200 family, p202, can indirectly interact with p53 via the p53 binding protein (p53bp) and inhibit p53-mediated transcriptional activation. The binding activity of p202 to p53bp was shown to require the conserved MFHATVAT motif present in all 200 amino acid repeat regions of HIN-200 proteins. Given that IFI 16 contains two MFHATVAT motifs, we sought to determine whether IFI 16 may form a complex with p53 and if so to ascertain the functional significance of this interaction. We demonstrate that IFI 16 can directly bind to the C-terminal region of p53 and augment p53-mediated transcriptional activation without altering the steady state levels of p53. Thus, in addition to its ability to directly regulate gene expression, IFI 16 can also modulate the transcription function of other cellular transcription factors. These findings demonstrate a possible link between gene induction following interferon stimulation and p53-mediated cellular events.
datePublished:2000-12-07T00:00:00Z
dateModified:2000-12-07T00:00:00Z
pageStart:6033
pageEnd:6042
sameAs:https://doi.org/10.1038/sj.onc.1204005
keywords:
transcription
IFI 16
p53
interferon
Medicine/Public Health
general
Internal Medicine
Cell Biology
Human Genetics
Oncology
Apoptosis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1204005/MediaObjects/41388_2000_Article_BF1204005_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1204005/MediaObjects/41388_2000_Article_BF1204005_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1204005/MediaObjects/41388_2000_Article_BF1204005_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fsj.onc.1204005/MediaObjects/41388_2000_Article_BF1204005_Fig4_HTML.jpg
isPartOf:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:19
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Ricky W Johnstone
affiliation:
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
type:Organization
type:Person
name:Wu Wei
affiliation:
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
type:Organization
type:Person
name:Alison Greenway
affiliation:
name:The Macfarlane Burnet Centre for Medical Research
address:
name:The Macfarlane Burnet Centre for Medical Research, Fairfield, Australia
type:PostalAddress
type:Organization
type:Person
name:Joseph A Trapani
affiliation:
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:19
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
name:The Macfarlane Burnet Centre for Medical Research
address:
name:The Macfarlane Burnet Centre for Medical Research, Fairfield, Australia
type:PostalAddress
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Ricky W Johnstone
affiliation:
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
type:Organization
name:Wu Wei
affiliation:
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
type:Organization
name:Alison Greenway
affiliation:
name:The Macfarlane Burnet Centre for Medical Research
address:
name:The Macfarlane Burnet Centre for Medical Research, Fairfield, Australia
type:PostalAddress
type:Organization
name:Joseph A Trapani
affiliation:
name:The Peter MacCallum Cancer Institute, Gene Regulation Laboratory
address:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
type:PostalAddress
type:Organization
PostalAddress:
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
name:The Macfarlane Burnet Centre for Medical Research, Fairfield, Australia
name:Cancer Immunology Division, The Peter MacCallum Cancer Institute, Gene Regulation Laboratory, Australia
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {π}(21)
- How much income is https://link.springer.com/article/10.1038/sj.onc.1204005?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle earning monthly?
- Find out how much https://citation-needed.springer.com/v2/references/10.1038/sj.onc.1204005?format=refman&flavour=references earns monthly
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ricky%20W%20Johnstone
- What's the monthly income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ricky%20W%20Johnstone%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Wu%20Wei earning monthly?
- Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Wu%20Wei%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Alison%20Greenway's total income per month
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Alison%20Greenway%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
- What's the financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Joseph%20A%20Trapani?
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Joseph%20A%20Trapani%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in?
- How much does https://s100.copyright.com/AppDispatchServlet?title=Functional%20interaction%20between%20p53%20and%20the%20interferon-inducible%20nucleoprotein%20IFI%2016&author=Ricky%20W%20Johnstone%20et%20al&contentID=10.1038%2Fsj.onc.1204005©right=Macmillan%20Publishers%20Limited&publication=0950-9232&publicationDate=2000-12-07&publisherName=SpringerNature&orderBeanReset=true pull in monthly?
- How much revenue does https://citation-needed.springer.com/v2/references/10.1038/sj.onc.1204005?format=refman&flavour=citation generate?
- What's the financial intake of https://doi.org/10.1007/s00018-022-04333-y?
- How much income is https://doi.org/10.1186/s12935-021-02409-6 earning monthly?
- Financial intake of https://doi.org/10.1038/srep28776
- https://doi.org/10.1038/aps.2014.106's revenue stream
- How much revenue does https://doi.org/10.1038/sj.jid.5701082 produce monthly?
- Monthly income for https://www.protocols.io/
- Financial intake of https://www.natureindex.com/
- Profit of http://www.naturechina.com
- How much cash flow does https://www.natureasia.com/ja-jp have monthly?
Analytics and Tracking {π}
- Google Tag Manager
Libraries {π}
- Prism.js
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk