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We began analyzing https://www.nature.com/articles/s41467-019-09361-0, but it redirected us to https://www.nature.com/articles/s41467-019-09361-0. The analysis below is for the second page.

Title[redir]:
The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis | Nature Communications
Description:
The human immune system has evolved in the context of our colonisation by bacteria, viruses, fungi and parasitic helminths. Reflecting this, the rapid eradication of pathogens appears to have resulted in reduced microbiome diversity and generation of chronically activated immune systems, presaging the recent rise of allergic, autoimmune and metabolic disorders. Certainly, gastrointestinal helminths can protect against gut and lung mucosa inflammatory conditions by modulating the microbiome and suppressing the chronic inflammation associated with dysbiosis. Here, we employ ES-62, an immunomodulator secreted by tissue-dwelling Acanthocheilonema viteae to show that helminth-modulation of the gut microbiome does not require live infection with gastrointestinal-based worms nor is protection restricted to mucosal diseases. Specifically, subcutaneous administration of this defined immunomodulator affords protection against joint disease in collagen-induced arthritis, a mouse model of rheumatoid arthritis, which is associated with normalisation of gut microbiota and prevention of loss of intestinal barrier integrity. Gastrointestinal infection with parasitic helminths can protect against mucosal diseases via impacting on the microbiome. Here the authors show that ES-62, a product secreted by a tissue-resident helminth modulates the host gut microbiome to protect against inflammatory arthritis in a mouse model.

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Keywords {🔍}

mice, article, cia, gut, google, scholar, microbiome, arthritis, naive, fig, pbs, disease, cas, inflammation, cells, colon, data, pathology, abx, analysis, microbiota, bone, inflammatory, intestinal, ileum, bacteria, initiation, nature, levels, animals, treatment, protection, pbscia, joint, regulatory, autoimmune, models, cell, parasitic, articular, dysbiosis, responses, normalised, bacterial, established, esabx, model, day, product, harnett,

Topics {✒️}

nature portfolio privacy policy nature communications central research facility advertising clinical research ed arthritis research uk short-chain fatty acids social media middle row author information authors parasitic worm-derived immunomodulator mitigate graft-versus-host disease nature 504 nature gut microbiota-driven interleukin-1beta reprints t-shaped grasping bar italy 16s rdna-targeted primers effector b-cell responses fishers lsd post-tests original author filarial nematode-derived phosphorylcholine tissue-dwelling acanthocheilonema viteae barcoded libraries blood-borne parasitic worms cd3-b220-ter119−ly6g−ly6c+ endotoxin-free eppendorf tubes reference gene β-actin parasitic worm product interleukin-17-producing cellular network double-blind clinical trial 30 ng/ml m-csf downregulate aberrant myd88-responses fine-tune microbiome homoeostasis nrf2-mediated counter-regulation pre-designed kicqstart™ primers pathogenic anti-cii antibody attachment/effacement lesions induced library preparation permissions anti-cii ig2a levels quorum-sensing activities contribute gut-bone marrow axis maintain butyrate-mediated protection real-time pcr analysis intestinal epithelial barrier real-time pcr quantification local gut-protecting actions

Questions {❓}

Can parasitic worms cure the modern world’s ills?
A marker of health?

Schema {🗺️}

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