We are analyzing https://link.springer.com/article/10.1186/ar3287.

Title:
Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium | Arthritis Research & Therapy
Description:
Synovial tissue of patients with rheumatoid arthritis (RA) spontaneously produces several cytokines, of which a fundamental role in joint inflammation and destruction has been established. However, the factors sustaining this phenomenon remain poorly understood. In a recent report, blockade of Toll-like receptor 2 (TLR2) was found to inhibit the spontaneous release of inflammatory cytokines by intact RA synovial explant cultures. Adding to the recent evidence implicating other TLRs (in particular, TLR4), this observation highlights the potential of TLRs as therapeutic targets to suppress the local production of multiple cytokines and to control the chronic inflammatory loop in RA.
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Keywords {🔍}

tlr, arthritis, van, pubmed, article, synovial, production, rheumatoid, google, scholar, tolllike, spontaneous, cas, receptor, inflammatory, berg, tissue, receptors, cytokine, abdollahiroodsaz, patients, cytokines, tlrs, central, cells, research, loop, blockade, function, role, joint, destruction, cultures, rheumatology, tnfα, model, joosten, privacy, cookies, loo, inflammation, evidence, colleagues, nic, ultaigh, information, publish, search, therapy, vicious,

Topics {✒️}

article abdollahi-roodsaz tumor necrosis factor-alpha anti-body significantly suppressed van de loo van den berg tlr-mediated inflammatory response synovial explant cultures tlr-targeted therapy privacy choices/manage cookies abdollahi-roodsaz cell-mediated arthritis van gaalen fa synovial tissue explants van lent pl additional endogenous ligands severe-combined immunodeficient den brok mh humanized ra-scid model central role arthritis res ther evidence links tlr spontaneous cytokine production fcγ receptor response pattern-recognition receptors autoimmune destructive arthritis cytokine production induced ra synovial tissue european economic area recognize conserved microbe endogenous ligands serve methods mol biol alternatively spliced eda adaptive immune response drive spontaneous production rheumatology health professionals anti-inflammatory functions ra synovial tissues tlr4 markedly suppressed tissue-destructive enzymes dominant-negative form solid therapeutic target recently introduced concept article number 105 article cite ra peripheral blood ann rheum dis o'neill la vicious inflammatory cycle references nic chronic inflammatory loop

Schema {🗺️}

WebPage:
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         headline:Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium
         description:Synovial tissue of patients with rheumatoid arthritis (RA) spontaneously produces several cytokines, of which a fundamental role in joint inflammation and destruction has been established. However, the factors sustaining this phenomenon remain poorly understood. In a recent report, blockade of Toll-like receptor 2 (TLR2) was found to inhibit the spontaneous release of inflammatory cytokines by intact RA synovial explant cultures. Adding to the recent evidence implicating other TLRs (in particular, TLR4), this observation highlights the potential of TLRs as therapeutic targets to suppress the local production of multiple cytokines and to control the chronic inflammatory loop in RA.
         datePublished:2011-03-30T00:00:00Z
         dateModified:2011-03-30T00:00:00Z
         pageStart:1
         pageEnd:3
         sameAs:https://doi.org/10.1186/ar3287
         keywords:
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               affiliation:
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ScholarlyArticle:
      headline:Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium
      description:Synovial tissue of patients with rheumatoid arthritis (RA) spontaneously produces several cytokines, of which a fundamental role in joint inflammation and destruction has been established. However, the factors sustaining this phenomenon remain poorly understood. In a recent report, blockade of Toll-like receptor 2 (TLR2) was found to inhibit the spontaneous release of inflammatory cytokines by intact RA synovial explant cultures. Adding to the recent evidence implicating other TLRs (in particular, TLR4), this observation highlights the potential of TLRs as therapeutic targets to suppress the local production of multiple cytokines and to control the chronic inflammatory loop in RA.
      datePublished:2011-03-30T00:00:00Z
      dateModified:2011-03-30T00:00:00Z
      pageStart:1
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      sameAs:https://doi.org/10.1186/ar3287
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         Rheumatology
         Orthopedics
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            affiliation:
                  name:Radboud University Nijmegen Medical Centre
                  address:
                     name:Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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                  name:Radboud University Nijmegen Medical Centre
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            address:
               name:Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
               type:PostalAddress
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      name:Fons AJ van de Loo
      affiliation:
            name:Radboud University Nijmegen Medical Centre
            address:
               name:Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
               type:PostalAddress
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      name:Wim B van den Berg
      affiliation:
            name:Radboud University Nijmegen Medical Centre
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               name:Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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PostalAddress:
      name:Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
      name:Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
      name:Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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