
DOI . ORG {
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Title[redir]:
Associations between different dimensions of prenatal distress, neonatal hippocampal connectivity, and infant memory | Neuropsychopharmacology
Description:
Prenatal maternal distressâan umbrella concept encompassing multiple negative psychological states including stress, anxiety, and depressionâis a substantial prenatal exposure. Consistent across preclinical and human studies, the hippocampus displays alterations due to prenatal distress. Nevertheless, most prenatal distress studies do not focus on multiple dimensions of, have not examined hippocampal functional connectivity in association with, and do not consider observer-based functional outcomes related to distress. We investigated the effects of different dimensions of prenatal distress in pregnant adolescents, a population at high risk for distress, in association with neonatal hippocampal connectivity and infant memory. In pregnant adolescents (nâ=â42), we collected four measures of distress (perceived stress, depression, pregnancy-specific distress, and 24-h ambulatory salivary cortisol) during the 2nd and 3rd trimesters. Resting-state imaging data were acquired in their infants at 40â44 weeks post-menstrual age. Functional connectivity was measured from hippocampal seeds. Memory abilities were obtained at 4 months using the mobile conjugate reinforcement task. Shared across different dimensions of maternal distress, increased 3rd trimester maternal distress associated with weaker hippocampalâcingulate cortex connectivity and stronger hippocampalâtemporal lobe connectivity. Perceived stress inversely correlated while hippocampalâcingulate cortex connectivity positively correlated with infant memory. Increased cortisolâcollected during the 2nd, but not the 3rd, trimesterâassociated with weaker hippocampalâcingulate cortex connectivity and stronger hippocampalâtemporal lobe connectivity. Different dimensions of prenatal maternal distress likely contribute shared and unique effects to shaping infant brain and behavior.
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connectivity, distress, maternal, pubmed, stress, scholar, google, prenatal, hippocampus, hippocampal, trimester, cortisol, brain, depression, infant, functional, data, associations, memory, dimensions, perceived, central, cas, left, collected, measures, temporal, lobe, fig, nature, cortex, pregnancy, higher, anxiety, weaker, effects, infants, images, psychiatry, pregnancyspecific, development, size, article, neonatal, scheinost, neonates, average, weeks, age, study,
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nature portfolio longitudinal nature privacy policy advertising nature biological index middle cingulate cortex social media research assistants reprints attention-deficit/hyperactivity disorder resting-state imaging data full-width half-maximum long-term retention ratio longâterm retention ratio resting-state functional connectivity include hypothalamicâpituitaryâadrenal mannâwhitney u-tests maternal hypothalamicâpituitaryâadrenal higher long-term retention brain-derived neurotrophic factor voxel-wise linear models regulate distress-related homeostasis hippocampalâdiencephalicâcingulate networks hypothalamicâpituitaryâadrenal axis hypothalamic-pituitary-adrenal axis long-term retention period cluster-level correction estimated glucocorticoid receptor-dependent mechanisms long-term memory formation european economic area resting-state data permissions similar large-scale regions rigid-body motion parameters late pregnancy alters maternal pregnancy-specific distress maternal distress affects policy 24-parameter motion model important intellectual content pregnancy-specific distress clusters author correspondence original author motion-related confounds fetal neurobehavioral development placenta glucocorticoid-related genes usable functional data download pdf weaker hippocampalâpcc connectivity
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- Does prenatal stress alter the developing connectome?
- The hippocampal-prefrontal pathway: the weak link in psychiatric disorders?
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headline:Associations between different dimensions of prenatal distress, neonatal hippocampal connectivity, and infant memory
description:Prenatal maternal distressâÂÂan umbrella concept encompassing multiple negative psychological states including stress, anxiety, and depressionâÂÂis a substantial prenatal exposure. Consistent across preclinical and human studies, the hippocampus displays alterations due to prenatal distress. Nevertheless, most prenatal distress studies do not focus on multiple dimensions of, have not examined hippocampal functional connectivity in association with, and do not consider observer-based functional outcomes related to distress. We investigated the effects of different dimensions of prenatal distress in pregnant adolescents, a population at high risk for distress, in association with neonatal hippocampal connectivity and infant memory. In pregnant adolescents (nâÂÂ=âÂÂ42), we collected four measures of distress (perceived stress, depression, pregnancy-specific distress, and 24-h ambulatory salivary cortisol) during the 2nd and 3rd trimesters. Resting-state imaging data were acquired in their infants at 40âÂÂ44 weeks post-menstrual age. Functional connectivity was measured from hippocampal seeds. Memory abilities were obtained at 4 months using the mobile conjugate reinforcement task. Shared across different dimensions of maternal distress, increased 3rd trimester maternal distress associated with weaker hippocampalâÂÂcingulate cortex connectivity and stronger hippocampalâÂÂtemporal lobe connectivity. Perceived stress inversely correlated while hippocampalâÂÂcingulate cortex connectivity positively correlated with infant memory. Increased cortisolâÂÂcollected during the 2nd, but not the 3rd, trimesterâÂÂassociated with weaker hippocampalâÂÂcingulate cortex connectivity and stronger hippocampalâÂÂtemporal lobe connectivity. Different dimensions of prenatal maternal distress likely contribute shared and unique effects to shaping infant brain and behavior.
datePublished:2020-04-18T00:00:00Z
dateModified:2020-04-18T00:00:00Z
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headline:Associations between different dimensions of prenatal distress, neonatal hippocampal connectivity, and infant memory
description:Prenatal maternal distressâÂÂan umbrella concept encompassing multiple negative psychological states including stress, anxiety, and depressionâÂÂis a substantial prenatal exposure. Consistent across preclinical and human studies, the hippocampus displays alterations due to prenatal distress. Nevertheless, most prenatal distress studies do not focus on multiple dimensions of, have not examined hippocampal functional connectivity in association with, and do not consider observer-based functional outcomes related to distress. We investigated the effects of different dimensions of prenatal distress in pregnant adolescents, a population at high risk for distress, in association with neonatal hippocampal connectivity and infant memory. In pregnant adolescents (nâÂÂ=âÂÂ42), we collected four measures of distress (perceived stress, depression, pregnancy-specific distress, and 24-h ambulatory salivary cortisol) during the 2nd and 3rd trimesters. Resting-state imaging data were acquired in their infants at 40âÂÂ44 weeks post-menstrual age. Functional connectivity was measured from hippocampal seeds. Memory abilities were obtained at 4 months using the mobile conjugate reinforcement task. Shared across different dimensions of maternal distress, increased 3rd trimester maternal distress associated with weaker hippocampalâÂÂcingulate cortex connectivity and stronger hippocampalâÂÂtemporal lobe connectivity. Perceived stress inversely correlated while hippocampalâÂÂcingulate cortex connectivity positively correlated with infant memory. Increased cortisolâÂÂcollected during the 2nd, but not the 3rd, trimesterâÂÂassociated with weaker hippocampalâÂÂcingulate cortex connectivity and stronger hippocampalâÂÂtemporal lobe connectivity. Different dimensions of prenatal maternal distress likely contribute shared and unique effects to shaping infant brain and behavior.
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