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connectivity, distress, maternal, pubmed, stress, scholar, google, prenatal, hippocampus, hippocampal, trimester, cortisol, brain, depression, infant, functional, data, associations, memory, dimensions, perceived, central, cas, left, collected, measures, temporal, lobe, fig, nature, cortex, pregnancy, higher, anxiety, weaker, effects, infants, images, psychiatry, pregnancyspecific, development, size, article, neonatal, scheinost, neonates, average, weeks, age, study,

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nature portfolio longitudinal nature privacy policy advertising nature biological index middle cingulate cortex social media research assistants reprints attention-deficit/hyperactivity disorder resting-state imaging data full-width half-maximum long-term retention ratio long‐term retention ratio resting-state functional connectivity include hypothalamic–pituitary–adrenal mann–whitney u-tests maternal hypothalamic–pituitary–adrenal higher long-term retention brain-derived neurotrophic factor voxel-wise linear models regulate distress-related homeostasis hippocampal–diencephalic–cingulate networks hypothalamic–pituitary–adrenal axis hypothalamic-pituitary-adrenal axis long-term retention period cluster-level correction estimated glucocorticoid receptor-dependent mechanisms long-term memory formation european economic area resting-state data permissions similar large-scale regions rigid-body motion parameters late pregnancy alters maternal pregnancy-specific distress maternal distress affects policy 24-parameter motion model important intellectual content pregnancy-specific distress clusters author correspondence original author motion-related confounds fetal neurobehavioral development placenta glucocorticoid-related genes usable functional data download pdf weaker hippocampal–pcc connectivity

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         headline:Associations between different dimensions of prenatal distress, neonatal hippocampal connectivity, and infant memory
         description:Prenatal maternal distress—an umbrella concept encompassing multiple negative psychological states including stress, anxiety, and depression—is a substantial prenatal exposure. Consistent across preclinical and human studies, the hippocampus displays alterations due to prenatal distress. Nevertheless, most prenatal distress studies do not focus on multiple dimensions of, have not examined hippocampal functional connectivity in association with, and do not consider observer-based functional outcomes related to distress. We investigated the effects of different dimensions of prenatal distress in pregnant adolescents, a population at high risk for distress, in association with neonatal hippocampal connectivity and infant memory. In pregnant adolescents (n = 42), we collected four measures of distress (perceived stress, depression, pregnancy-specific distress, and 24-h ambulatory salivary cortisol) during the 2nd and 3rd trimesters. Resting-state imaging data were acquired in their infants at 40–44 weeks post-menstrual age. Functional connectivity was measured from hippocampal seeds. Memory abilities were obtained at 4 months using the mobile conjugate reinforcement task. Shared across different dimensions of maternal distress, increased 3rd trimester maternal distress associated with weaker hippocampal–cingulate cortex connectivity and stronger hippocampal–temporal lobe connectivity. Perceived stress inversely correlated while hippocampal–cingulate cortex connectivity positively correlated with infant memory. Increased cortisol—collected during the 2nd, but not the 3rd, trimester—associated with weaker hippocampal–cingulate cortex connectivity and stronger hippocampal–temporal lobe connectivity. Different dimensions of prenatal maternal distress likely contribute shared and unique effects to shaping infant brain and behavior.
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      headline:Associations between different dimensions of prenatal distress, neonatal hippocampal connectivity, and infant memory
      description:Prenatal maternal distress—an umbrella concept encompassing multiple negative psychological states including stress, anxiety, and depression—is a substantial prenatal exposure. Consistent across preclinical and human studies, the hippocampus displays alterations due to prenatal distress. Nevertheless, most prenatal distress studies do not focus on multiple dimensions of, have not examined hippocampal functional connectivity in association with, and do not consider observer-based functional outcomes related to distress. We investigated the effects of different dimensions of prenatal distress in pregnant adolescents, a population at high risk for distress, in association with neonatal hippocampal connectivity and infant memory. In pregnant adolescents (n = 42), we collected four measures of distress (perceived stress, depression, pregnancy-specific distress, and 24-h ambulatory salivary cortisol) during the 2nd and 3rd trimesters. Resting-state imaging data were acquired in their infants at 40–44 weeks post-menstrual age. Functional connectivity was measured from hippocampal seeds. Memory abilities were obtained at 4 months using the mobile conjugate reinforcement task. Shared across different dimensions of maternal distress, increased 3rd trimester maternal distress associated with weaker hippocampal–cingulate cortex connectivity and stronger hippocampal–temporal lobe connectivity. Perceived stress inversely correlated while hippocampal–cingulate cortex connectivity positively correlated with infant memory. Increased cortisol—collected during the 2nd, but not the 3rd, trimester—associated with weaker hippocampal–cingulate cortex connectivity and stronger hippocampal–temporal lobe connectivity. Different dimensions of prenatal maternal distress likely contribute shared and unique effects to shaping infant brain and behavior.
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