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  2. Matching Content Categories
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  4. Monthly Traffic Estimate
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We began analyzing https://www.nature.com/articles/nsmb.3005, but it redirected us to https://www.nature.com/articles/nsmb.3005. The analysis below is for the second page.

Title[redir]:
A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature | Nature Structural & Molecular Biology
Description:
The evolutionarily conserved antisense long noncoding RNA asFGFR2 influences cell type–specific alternative-splicing patterns of FGFR2 by recruiting chromatin modifiers to the locus. Alternative pre-mRNA splicing is a highly cell type–specific process essential to generating protein diversity. However, the mechanisms responsible for the establishment and maintenance of heritable cell-specific alternative-splicing programs are poorly understood. Recent observations point to a role of histone modifications in the regulation of alternative splicing. Here we report a new mechanism of chromatin-mediated splicing control involving a long noncoding RNA (lncRNA). We have identified an evolutionarily conserved nuclear antisense lncRNA, generated from within the human FGFR2 locus, that promotes epithelial-specific alternative splicing of FGFR2. The lncRNA acts through recruitment of Polycomb-group proteins and the histone demethylase KDM2a to create a chromatin environment that impairs binding of a repressive chromatin-splicing adaptor complex important for mesenchymal-specific splicing. Our results uncover a new function for lncRNAs in the establishment and maintenance of cell-specific alternative splicing via modulation of chromatin signatures.

Matching Content Categories {📚}

  • Science
  • Education
  • Politics

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

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Keywords {🔍}

fgfr, article, splicing, google, scholar, cas, control, cells, iiib, asfgfr, levels, iiic, values, nature, rna, exons, alternative, hmsc, sem, pnt, normalized, kdma, qrtpcr, supplementary, antisense, inclusion, expression, cell, relative, total, lncrna, mol, ezh, chromatin, esrp, exon, depicted, negative, tailed, students, ttest, noncoding, access, red, black, cyclophilin, hkme, histone, long, human,

Topics {✒️}

nature portfolio permissions reprints privacy policy advertising intramural research program cancer research ptb-dependent spliced pkm2-e9 epithelial cell-type-specific regulators social media nature 456 nature 465 nature 479 nature 472 nature biotech research splicing-specific chromatin signature lys36-methylated histone h3 long con-coding rnas alternative pre-mrna splicing long noncoding rna cell-specific alternative splicing polycomb/trithorax epigenetic switch strand-specific qrt-pcr emt-markers e-cadherin strand-specific rt-pcr springerlink instant access alternative isoform regulation permissions mcf10a-snail-er cells noncoding rna anril national cancer institute chromatin signature characteristic personal data x-fold change relative mesenchymal-specific splicing data protection tissue-specific splicing structural properties evolutionarily conserved elements jichi medical school histone modification complexes fgfr2 pre-mrna antisense exon iiib strand-specific rt alternative splicing complexity privacy mesenchymal-transition system cancer drug resistance n7-methylguanosine modification spliced exons iiib

Schema {🗺️}

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         headline:A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature
         description:The evolutionarily conserved antisense long noncoding RNA asFGFR2 influences cell type–specific alternative-splicing patterns of FGFR2 by recruiting chromatin modifiers to the locus. Alternative pre-mRNA splicing is a highly cell type–specific process essential to generating protein diversity. However, the mechanisms responsible for the establishment and maintenance of heritable cell-specific alternative-splicing programs are poorly understood. Recent observations point to a role of histone modifications in the regulation of alternative splicing. Here we report a new mechanism of chromatin-mediated splicing control involving a long noncoding RNA (lncRNA). We have identified an evolutionarily conserved nuclear antisense lncRNA, generated from within the human FGFR2 locus, that promotes epithelial-specific alternative splicing of FGFR2. The lncRNA acts through recruitment of Polycomb-group proteins and the histone demethylase KDM2a to create a chromatin environment that impairs binding of a repressive chromatin-splicing adaptor complex important for mesenchymal-specific splicing. Our results uncover a new function for lncRNAs in the establishment and maintenance of cell-specific alternative splicing via modulation of chromatin signatures.
         datePublished:2015-04-06T00:00:00Z
         dateModified:2015-04-06T00:00:00Z
         pageStart:370
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            Histone post-translational modifications
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            Life Sciences
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            Protein Structure
            Membrane Biology
            Biological Microscopy
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      headline:A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature
      description:The evolutionarily conserved antisense long noncoding RNA asFGFR2 influences cell type–specific alternative-splicing patterns of FGFR2 by recruiting chromatin modifiers to the locus. Alternative pre-mRNA splicing is a highly cell type–specific process essential to generating protein diversity. However, the mechanisms responsible for the establishment and maintenance of heritable cell-specific alternative-splicing programs are poorly understood. Recent observations point to a role of histone modifications in the regulation of alternative splicing. Here we report a new mechanism of chromatin-mediated splicing control involving a long noncoding RNA (lncRNA). We have identified an evolutionarily conserved nuclear antisense lncRNA, generated from within the human FGFR2 locus, that promotes epithelial-specific alternative splicing of FGFR2. The lncRNA acts through recruitment of Polycomb-group proteins and the histone demethylase KDM2a to create a chromatin environment that impairs binding of a repressive chromatin-splicing adaptor complex important for mesenchymal-specific splicing. Our results uncover a new function for lncRNAs in the establishment and maintenance of cell-specific alternative splicing via modulation of chromatin signatures.
      datePublished:2015-04-06T00:00:00Z
      dateModified:2015-04-06T00:00:00Z
      pageStart:370
      pageEnd:376
      sameAs:https://doi.org/10.1038/nsmb.3005
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         Alternative splicing
         Histone post-translational modifications
         Long non-coding RNAs
         Life Sciences
         general
         Biochemistry
         Protein Structure
         Membrane Biology
         Biological Microscopy
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            name:Travis A Dittmer
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Social Networks {👍}(1)

External Links {🔗}(210)

Analytics and Tracking {📊}

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Libraries {📚}

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  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

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Name Servers:

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CDN Services {📦}

  • Crossref

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