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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
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  15. CDN Services

We began analyzing https://www.nature.com/articles/npp201273, but it redirected us to https://www.nature.com/articles/npp201273. The analysis below is for the second page.

Title[redir]:
Epigenetics of the Depressed Brain: Role of Histone Acetylation and Methylation | Neuropsychopharmacology
Description:
Major depressive disorder is a chronic, remitting syndrome involving widely distributed circuits in the brain. Stable alterations in gene expression that contribute to structural and functional changes in multiple brain regions are implicated in the heterogeneity and pathogenesis of the illness. Epigenetic events that alter chromatin structure to regulate programs of gene expression have been associated with depression-related behavior, antidepressant action, and resistance to depression or ‘resilience’ in animal models, with increasing evidence for similar mechanisms occurring in postmortem brains of depressed humans. In this review, we discuss recent advances in our understanding of epigenetic contributions to depression, in particular the role of histone acetylation and methylation, which are revealing novel mechanistic insight into the syndrome that may aid in the development of novel targets for depression treatment.

Matching Content Categories {📚}

  • Health & Fitness
  • Education
  • Family & Parenting

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We can't see how the site brings in money.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Doi.org might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

pubmed, article, google, scholar, histone, stress, cas, depression, chronic, acetylation, methylation, social, hdac, central, epigenetic, defeat, nac, expression, hippocampus, studies, decreased, study, gene, models, levels, antidepressant, treatment, bdnf, chromatin, increased, brain, role, genes, regions, animals, covington, neurosci, hkme, regulation, molecular, patients, depressed, nestler, mice, effects, observed, modifications, psychiatry, global, nature,

Topics {✒️}

n-methyl-d-aspartate/extracellular signal-regulated kinase/mitogen nature portfolio permissions reprints privacy policy basic research advertising research subjective nature social media nature 387 nature 447 nature 455 nature 403 nature regional specificity wnt-dishevelled-gsk3beta signaling cascade genome-wide association data brain-derived neurotrophic factor author correspondence anna-monika-prize paper perceptual attentional set-shifting unpublished genome-wide data corticotropin-releasing factor gene cortical-striatal-limbic circuit cortical-striatal-limbic circuitry study utilized chip-chip lacks s-nitrosylation sites atp-dependent chromatin remodelers american psychiatric association atp-dependent remodeling enzymes long-lasting behavioral consequences long-lasting behavioural forced swimming test central inflammatory cytokines low crh/ne states permissions ras-mapk-creb signaling g9a exerted pro-depressant epigenetic language stress-related memory formation major depressive disorder complex language n-terminal histone tails histone n-termini tails prolonged social isolation widespread h3k9/k27 methylation receptor tyrosine kinase behavioural-neurobiological concordance atp-dependent remodelers stress-regulated transcription factors

Questions {❓}

  • Histone acetylation: truth of consequences?
  • INTRODUCTION: WHY EPIGENETICS?
  • The above sections reviewed global changes in histone acetylation and methylation machineries in various depression models, but the far more important functional question is: at what specific genes or intergenic regions does such regulation occur to control depression-related behavior?

Schema {🗺️}

WebPage:
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         headline:Epigenetics of the Depressed Brain: Role of Histone Acetylation and Methylation
         description:Major depressive disorder is a chronic, remitting syndrome involving widely distributed circuits in the brain. Stable alterations in gene expression that contribute to structural and functional changes in multiple brain regions are implicated in the heterogeneity and pathogenesis of the illness. Epigenetic events that alter chromatin structure to regulate programs of gene expression have been associated with depression-related behavior, antidepressant action, and resistance to depression or ‘resilience’ in animal models, with increasing evidence for similar mechanisms occurring in postmortem brains of depressed humans. In this review, we discuss recent advances in our understanding of epigenetic contributions to depression, in particular the role of histone acetylation and methylation, which are revealing novel mechanistic insight into the syndrome that may aid in the development of novel targets for depression treatment.
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      headline:Epigenetics of the Depressed Brain: Role of Histone Acetylation and Methylation
      description:Major depressive disorder is a chronic, remitting syndrome involving widely distributed circuits in the brain. Stable alterations in gene expression that contribute to structural and functional changes in multiple brain regions are implicated in the heterogeneity and pathogenesis of the illness. Epigenetic events that alter chromatin structure to regulate programs of gene expression have been associated with depression-related behavior, antidepressant action, and resistance to depression or ‘resilience’ in animal models, with increasing evidence for similar mechanisms occurring in postmortem brains of depressed humans. In this review, we discuss recent advances in our understanding of epigenetic contributions to depression, in particular the role of histone acetylation and methylation, which are revealing novel mechanistic insight into the syndrome that may aid in the development of novel targets for depression treatment.
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      name:Fishberg Department of Neuroscience and Friedman Brain Institute, School of Medicine, New York, USA

Social Networks {👍}(2)

External Links {🔗}(672)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
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Name Servers:

  • josh.ns.cloudflare.com
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CDN Services {📦}

  • Crossref

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