We are analyzing https://link.springer.com/chapter/10.1007/7854_2010_109.

Title:
When the Serotonin Transporter Gene Meets Adversity: The Contribution of Animal Models to Understanding Epigenetic Mechanisms in Affective Disorders and Resilience | SpringerLink
Description:
Although converging epidemiological evidence links exposure to stressful life events with increased risk for affective spectrum disorders, there is extraordinary interindividual variability in vulnerability to adversity. The environmentally moderated penetrance of...
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google, scholar, pubmed, article, cas, serotonin, transporter, lesch, gene, neurosci, psychiatry, social, disorders, brain, polymorphism, murphy, epigenetic, stress, mice, genetic, variation, htt, behav, mol, depression, neural, rhesus, suomi, higley, models, adversity, early, sci, knockout, molecular, mechanisms, life, interaction, emotional, region, nat, meaney, chapter, affective, effects, environmental, httlpr, maternal, acad, processing,

Topics {✒️}

low-anxiety phenotype linked hypothalamic–pituitary–adrenal mri serotonin transporter-deficient mice serotonin transporter exhibit 5-ht event-related fmri study replicable gene-disorder associations csf monoamine metabolite google scholar serotonin transporter knockout serotonin transporter gene long-evans rats results barr cs common snps explain privacy choices/manage cookies murine serotonin transporter klaus-peter lesch serotonin transporter genotype serotonin transporter knock vesicular monoamine release stressful life events serotonin transporter polymorphism 5-ht transporter confers high-affinity binding ren-patterson 5-ht transporter knock functional serotonin transporter serotonin transporter inactivation specific gene effects gene–environment interactions behav brain res boyce-rustay jm gimenez-amaya jm frontoparietal “mirror” network intermediate brain phenotypes cellular serotonin systems increases stress abnormalities alternative biallelic variation dell’acqua ml major psychiatric disorders identifying molecular substrates rhesus monkey neonates altering epigenetic marking european economic area extraordinary interindividual variability environmentally moderated penetrance unfavourable outcomes resembling gamma-aminobutyric acid watson kk von economo neurons medial frontal cortex

Questions {❓}

Anisman H, Zaharia MD, Meaney MJ, Merali Z (1998) Do early-life events permanently alter behavioral and hormonal responses to stressors?

Schema {🗺️}

ScholarlyArticle:
      headline:When the Serotonin Transporter Gene Meets Adversity: The Contribution of Animal Models to Understanding Epigenetic Mechanisms in Affective Disorders and Resilience
      pageEnd:280
      pageStart:251
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-19703-1.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Molecular and Functional Models in Neuropsychiatry
         isbn:
            978-3-642-19703-1
            978-3-642-19702-4
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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      author:
            name:Klaus-Peter Lesch
            affiliation:
                  name:University of Wuerzburg
                  address:
                     name:Molecular Psychiatry, ADHD Clinical Research Network, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Maastricht University
                  address:
                     name:Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School for Neuroscience (EURON), Maastricht University, Maastricht, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Cognition, Depression, Emotion, Environment, Epigenetics, Gene, Mouse, Primate, Resilience, Serotonin transporter
      description:Although converging epidemiological evidence links exposure to stressful life events with increased risk for affective spectrum disorders, there is extraordinary interindividual variability in vulnerability to adversity. The environmentally moderated penetrance of genetic variation is thought to play a major role in determining who will either develop disease or remain resilient. Research on genetic factors in the aetiology of disorders of emotion regulation has, nevertheless, been complicated by a mysterious discrepancy between high heritability estimates and a scarcity of replicable gene-disorder associations. One explanation for this incongruity is that at least some specific gene effects are conditional on environmental cues, i.e. gene-by-environment interaction (G × E) is present. For example, a remarkable number of studies reported an association of variation in the human serotonin (5-HT) transporter gene (SLC6A4, 5-HTT, SERT) with emotional and cognitive traits as well as increased risk for depression in interaction with psychosocial adversity. The results from investigations in non-human primate and mouse support the occurrence of G × E interaction by showing that variation of 5-HTT function is associated with a vulnerability to adversity across the lifespan leading to unfavourable outcomes resembling various neuropsychiatric disorders. The neural and molecular mechanisms by which environmental adversity in early life increases disease risk in adulthood are not known but may include epigenetic programming of gene expression during development. Epigenetic mechanisms, such as DNA methylation and chromatin modification, are dynamic and reversible and may also provide targets for intervention strategies (see Bountra et al., Curr Top Behav Neurosci, 2011). Animal models amenable to genetic manipulation are useful in the identification of molecular mechanisms underlying epigenetic programming by adverse environments and individual differences in resilience to stress. Therefore, deeper insight into the role of epigenetic regulation in the process of neurodevelopmental programmes is likely to result in early diagnosis of affective spectrum disorders and will contribute to the design of innovative treatments targeting neural pathways that foster resilience.
      datePublished:2011
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      name:Molecular and Functional Models in Neuropsychiatry
      isbn:
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         978-3-642-19702-4
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      name:Springer Berlin Heidelberg
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      name:University of Wuerzburg
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         name:Molecular Psychiatry, ADHD Clinical Research Network, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
         type:PostalAddress
      name:Maastricht University
      address:
         name:Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School for Neuroscience (EURON), Maastricht University, Maastricht, The Netherlands
         type:PostalAddress
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      name:Klaus-Peter Lesch
      affiliation:
            name:University of Wuerzburg
            address:
               name:Molecular Psychiatry, ADHD Clinical Research Network, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
               type:PostalAddress
            type:Organization
            name:Maastricht University
            address:
               name:Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School for Neuroscience (EURON), Maastricht University, Maastricht, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Molecular Psychiatry, ADHD Clinical Research Network, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
      name:Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School for Neuroscience (EURON), Maastricht University, Maastricht, The Netherlands
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