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  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
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We began analyzing https://www.nature.com/articles/nn2015, but it redirected us to https://www.nature.com/articles/nn2015. The analysis below is for the second page.

Title[redir]:
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions | Nature Neuroscience
Description:
Microglia are crucially important myeloid cells in the CNS and constitute the first immunological barrier against pathogens and environmental insults. The factors controlling microglia recruitment from the blood remain elusive and the direct circulating microglia precursor has not yet been identified in vivo. Using a panel of bone marrow chimeric and adoptive transfer experiments, we found that circulating Ly-6ChiCCR2+ monocytes were preferentially recruited to the lesioned brain and differentiated into microglia. Notably, microglia engraftment in CNS pathologies, which are not associated with overt blood-brain barrier disruption, required previous conditioning of brain (for example, by direct tissue irradiation). Our results identify Ly-6ChiCCR2+ monocytes as direct precursors of microglia in the adult brain and establish the importance of local factors in the adult CNS for microglia engraftment.

Matching Content Categories {📚}

  • Education
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  • Social Networks

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

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Keywords {🔍}

article, google, scholar, cas, nature, microglia, cells, brain, mice, microglial, bone, nat, prinz, access, content, monocytes, marrowderived, cns, neurosci, central, nervous, system, cookies, neuroscience, adult, response, hematopoietic, protein, med, privacy, priller, barrier, vivo, engraftment, local, green, model, monocyte, immunol, research, germany, function, data, information, lychiccr, hanisch, marco, recruitment, blood, direct,

Topics {✒️}

nature portfolio permissions reprints dfg research center privacy policy multiple sclerosis research beta-amyloid deposition advertising social media nature 425 nature monocyte chemotactic protein-1/ccl2 bone marrow–derived elements transcription factor nf-kappab bone marrow–derived cells bone marrow–derived microglia immune-mediated demyelinating diseases circulating ly-6chiccr2+ monocytes scientific input blood-brain barrier permeability intact blood-brain barrier author correspondence central nervous system defined host conditions personal data bone marrow–derived springerlink instant access data protection permissions cuprizone-induced cns demyelination ubiquitous green cells ly-6chiccr2+ monocytes modified chimeric mice bone marrow chimeric gfp bone marrow resident microglial cells follicular dendritic cells blood monocytes consist resting microglial cells perivascular microglial cells circulating monocytes engraft cuprizone-intoxicated mice privacy blood remain elusive nf-kappab inhibitor cuprizone-induced demyelination uwe-karsten hanisch chemokine receptor ccr2 chemokine receptors ccr2 marco prinz mice deficient

Schema {🗺️}

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      headline:Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
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Social Networks {👍}(1)

External Links {🔗}(240)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Foundation
  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

4.41s.