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We are analyzing https://www.nature.com/articles/nn2015.

Title:
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions | Nature Neuroscience
Description:
Microglia are crucially important myeloid cells in the CNS and constitute the first immunological barrier against pathogens and environmental insults. The factors controlling microglia recruitment from the blood remain elusive and the direct circulating microglia precursor has not yet been identified in vivo. Using a panel of bone marrow chimeric and adoptive transfer experiments, we found that circulating Ly-6ChiCCR2+ monocytes were preferentially recruited to the lesioned brain and differentiated into microglia. Notably, microglia engraftment in CNS pathologies, which are not associated with overt blood-brain barrier disruption, required previous conditioning of brain (for example, by direct tissue irradiation). Our results identify Ly-6ChiCCR2+ monocytes as direct precursors of microglia in the adult brain and establish the importance of local factors in the adult CNS for microglia engraftment.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
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Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,555,829 visitors per month in the current month.

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Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

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Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
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How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$536,300 per month
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Keywords {🔍}

article, google, scholar, cas, nature, microglia, cells, brain, mice, microglial, bone, nat, prinz, access, content, monocytes, marrowderived, cns, neurosci, central, nervous, system, cookies, neuroscience, adult, response, hematopoietic, protein, med, privacy, priller, barrier, vivo, engraftment, local, green, model, monocyte, immunol, research, germany, function, data, information, lychiccr, hanisch, marco, recruitment, blood, direct,

Topics {✒️}

nature portfolio permissions reprints dfg research center privacy policy multiple sclerosis research beta-amyloid deposition advertising social media nature 425 nature monocyte chemotactic protein-1/ccl2 bone marrow–derived elements transcription factor nf-kappab bone marrow–derived cells bone marrow–derived microglia immune-mediated demyelinating diseases circulating ly-6chiccr2+ monocytes scientific input blood-brain barrier permeability intact blood-brain barrier author correspondence central nervous system defined host conditions personal data bone marrow–derived springerlink instant access data protection permissions cuprizone-induced cns demyelination ubiquitous green cells ly-6chiccr2+ monocytes modified chimeric mice bone marrow chimeric gfp bone marrow resident microglial cells follicular dendritic cells blood monocytes consist resting microglial cells perivascular microglial cells circulating monocytes engraft cuprizone-intoxicated mice privacy blood remain elusive nf-kappab inhibitor cuprizone-induced demyelination uwe-karsten hanisch chemokine receptor ccr2 chemokine receptors ccr2 marco prinz mice deficient

Schema {🗺️}

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Social Networks {👍}(1)

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Analytics and Tracking {📊}

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Libraries {📚}

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Emails and Hosting {✉️}

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Name Servers:

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CDN Services {📦}

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