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article, google, scholar, cas, nature, osteoarthritis, senescence, senescent, cells, cell, aging, cartilage, access, development, data, research, content, sncs, role, cellular, nat, university, institute, kim, bone, experiments, cookies, campisi, chondrocyte, cancer, med, usa, jhe, privacy, medicine, laberge, baker, disease, expression, rev, drug, johns, hopkins, unity, biotechnology, designed, information, clearance, posttraumatic, jeon,

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nature portfolio journals permissions reprints nature portfolio privacy policy advertising kirby research center social media runx2-dependent bone development nature+ nature 509 nature 479 nature 530 nature photoreactive adhesive–hydrogel composite oarsi histopathology initiative—recommendations research intellectual property related age-related pathologies1 naturally occurring oa author correspondence p16-3mr transgenic mouse permissions springerlink instant access senescence-induced senescence increases healthy lifespan8 increased cartilage development european economic area remi-martin laberge targeting dna damage human cartilage repair privacy van den berg senescent cells attenuates johns hopkins university extracellular vesicles enriched chronic disease characterized bloomberg-kimmel institute subscription content synovial cells contributing matrix remodeling p53-dependent release temporomandibular joint osteoarthritis cartilage tissue isolated p16ink4a–rb pathway human term placenta issue learn chondrocyte terminal differentiation ulsan national institute explore content post-traumatic osteoarthritis

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• Does intra-articular injection of PRP help patients with temporomandibular joint osteoarthritis after joint puncture?
• Osteoarthritis—an untreatable disease?

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      headline:Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
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            address:
               name:Wilmer Eye Institute and the Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Do Hun Kim
      affiliation:
            name:Translational Tissue Engineering Center, Johns Hopkins University
            address:
               name:Wilmer Eye Institute and the Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Yan Poon
      affiliation:
            name:Unity Biotechnology, Inc.
            address:
               name:Unity Biotechnology, Inc., Brisbane, USA
               type:PostalAddress
            type:Organization
      name:Nathaniel David
      affiliation:
            name:Unity Biotechnology, Inc.
            address:
               name:Unity Biotechnology, Inc., Brisbane, USA
               type:PostalAddress
            type:Organization
      name:Darren J Baker
      affiliation:
            name:Mayo Clinic College of Medicine
            address:
               name:Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Jan M van Deursen
      affiliation:
            name:Mayo Clinic College of Medicine
            address:
               name:Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Judith Campisi
      affiliation:
            name:Buck Institute for Research on Aging
            address:
               name:Buck Institute for Research on Aging, Novato, USA
               type:PostalAddress
            type:Organization
            name:Lawrence Berkeley National Laboratory, University of California, Berkeley, Berkley, California, USA.
            address:
               name:Lawrence Berkeley National Laboratory, University of California, Berkeley, Berkley, California, USA.,
               type:PostalAddress
            type:Organization
      name:Jennifer H Elisseeff
      affiliation:
            name:Translational Tissue Engineering Center, Johns Hopkins University
            address:
               name:Wilmer Eye Institute and the Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Wilmer Eye Institute and the Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, USA
      name:Wilmer Eye Institute and the Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, USA
      name:Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, South Korea
      name:Buck Institute for Research on Aging, Novato, USA
      name:Unity Biotechnology, Inc., Brisbane, USA
      name:Buck Institute for Research on Aging, Novato, USA
      name:European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
      name:Wilmer Eye Institute and the Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, USA
      name:Unity Biotechnology, Inc., Brisbane, USA
      name:Wilmer Eye Institute and the Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, USA
      name:Wilmer Eye Institute and the Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, USA
      name:Unity Biotechnology, Inc., Brisbane, USA
      name:Unity Biotechnology, Inc., Brisbane, USA
      name:Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, USA
      name:Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, USA
      name:Buck Institute for Research on Aging, Novato, USA
      name:Lawrence Berkeley National Laboratory, University of California, Berkeley, Berkley, California, USA.,
      name:Wilmer Eye Institute and the Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, USA
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