Here's how LINK.SPRINGER.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1186/ar4494.

Title:
p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis | Arthritis Research & Therapy
Description:
Introduction Recent evidence suggests that tissue accumulation of senescent p16INK4a-positive cells during the life span would be deleterious for tissue functions and could be the consequence of inherent age-associated disorders. Osteoarthritis (OA) is characterized by the accumulation of chondrocytes expressing p16INK4a and markers of the senescence-associated secretory phenotype (SASP), including the matrix remodeling metalloproteases MMP1/MMP13 and pro-inflammatory cytokines interleukin-8 (IL-8) and IL-6. Here, we evaluated the role of p16INK4a in the OA-induced SASP and its regulation by microRNAs (miRs). Methods We used IL-1-beta-treated primary OA chondrocytes cultured in three-dimensional setting or mesenchymal stem cells differentiated into chondrocyte to follow p16INK4a expression. By transient transfection experiments and the use of knockout mice, we validate p16INK4a function in chondrocytes and its regulation by one miR identified by means of a genome-wide miR-array analysis. Results p16INK4a is induced upon IL-1-beta treatment and also during in vitro chondrogenesis. In the mouse model, Ink4a locus favors in vivo the proportion of terminally differentiated chondrocytes. When overexpressed in chondrocytes, p16INK4a is sufficient to induce the production of the two matrix remodeling enzymes, MMP1 and MMP13, thus linking senescence with OA pathogenesis and bone development. We identified miR-24 as a negative regulator of p16INK4a. Accordingly, p16INK4a expression increased while miR-24 level was repressed upon IL-1-beta addition, in OA cartilage and during in vitro terminal chondrogenesis. Conclusions We disclosed herein a new role of the senescence marker p16INK4a and its regulation by miR-24 during OA and terminal chondrogenesis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Careers

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

pubmed, pinka, chondrocytes, article, google, scholar, expression, cartilage, mmp, cas, cell, figure, differentiation, chondrocyte, central, cells, osteoarthritis, data, terminal, analysis, senescence, matrix, human, samples, inka, role, ilβ, primary, chondrogenesis, bone, growth, performed, remodeling, manuscript, mature, mirs, shown, senescenceassociated, vitro, days, mice, articular, microrna, reverse, protein, van, function, arthritis, phenotype, mouse,

Topics {✒️}

jean-marc brondello p16ink4a expression profile eleonora olivotto daniela platano lna dig-hsa-mir-24 probe prevent p16ink4a-dependent pathways interleukin-1-beta-treated mature chondrocytes genome-wide mir-array analysis archetypical cyclin-dependent inhibitor chu la peyronie de la recherche de la recherche” author correspondence rosa maria borzi chondrogenic medium—dmem supplemented article download pdf apa1/znf410 transcription factor ufr de medecine biotin-coupled secondary antibody mirna-induced silencing complex enzyme-linked immunosorbent assays enzyme-linked immunosorbent assay genome-wide microrna array direct axis mir-24-p16ink4a-mmp1 matrix morpho-functional analysis endochondral ossification suggests age-related degenerative disease multi-factorial complex disease accession number e-mtab-2229 locked nucleic acid-based hif-2α transcription factor dual luciferase/βgal kit de la hoz pml-rara increases expression unpaired mann-whitney test paraffin-embedded sample sections human primary chondrocytes endochondral ossification process endochondral-induced terminal chondrogenesis danièle noel streptavidin/biotin blocking kit recombinant human il-1β luciferase/β-gal activities van de sluis anti-cdkn2a/p16ink4a age-related disease onset p16ink4a-positive cells exhibit interleukin-1-beta-treated chondrocytes brondello jm service chirugie orthopédique

Questions {❓}

  • Campisi J, Andersen JK, Kapahi P, Melov S: Cellular senescence: a link between cancer and age-related degenerative disease?
  • How could p16INK4a control MMPs production?
  • Van der Kraan PM, van den Berg WB: Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis
         description:Recent evidence suggests that tissue accumulation of senescent p16INK4a-positive cells during the life span would be deleterious for tissue functions and could be the consequence of inherent age-associated disorders. Osteoarthritis (OA) is characterized by the accumulation of chondrocytes expressing p16INK4a and markers of the senescence-associated secretory phenotype (SASP), including the matrix remodeling metalloproteases MMP1/MMP13 and pro-inflammatory cytokines interleukin-8 (IL-8) and IL-6. Here, we evaluated the role of p16INK4a in the OA-induced SASP and its regulation by microRNAs (miRs). We used IL-1-beta-treated primary OA chondrocytes cultured in three-dimensional setting or mesenchymal stem cells differentiated into chondrocyte to follow p16INK4a expression. By transient transfection experiments and the use of knockout mice, we validate p16INK4a function in chondrocytes and its regulation by one miR identified by means of a genome-wide miR-array analysis. p16INK4a is induced upon IL-1-beta treatment and also during in vitro chondrogenesis. In the mouse model, Ink4a locus favors in vivo the proportion of terminally differentiated chondrocytes. When overexpressed in chondrocytes, p16INK4a is sufficient to induce the production of the two matrix remodeling enzymes, MMP1 and MMP13, thus linking senescence with OA pathogenesis and bone development. We identified miR-24 as a negative regulator of p16INK4a. Accordingly, p16INK4a expression increased while miR-24 level was repressed upon IL-1-beta addition, in OA cartilage and during in vitro terminal chondrogenesis. We disclosed herein a new role of the senescence marker p16INK4a and its regulation by miR-24 during OA and terminal chondrogenesis.
         datePublished:2014-02-27T00:00:00Z
         dateModified:2014-02-27T00:00:00Z
         pageStart:1
         pageEnd:12
         license:http://creativecommons.org/licenses/by/2.0/
         sameAs:https://doi.org/10.1186/ar4494
         keywords:
            Chondrogenic Differentiation
            Endochondral Ossification
            Primary Chondrocytes
            p16INK4a Expression
            Mature Chondrocytes
            Rheumatology
            Orthopedics
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Far4494/MediaObjects/13075_2013_Article_4250_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Far4494/MediaObjects/13075_2013_Article_4250_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Far4494/MediaObjects/13075_2013_Article_4250_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Far4494/MediaObjects/13075_2013_Article_4250_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Far4494/MediaObjects/13075_2013_Article_4250_Fig5_HTML.jpg
         isPartOf:
            name:Arthritis Research & Therapy
            issn:
               1478-6362
            volumeNumber:16
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Didier Philipot
               affiliation:
                     name:INSERM U844, CHU St Eloi, Bat INM
                     address:
                        name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                        type:PostalAddress
                     type:Organization
                     name:Université de Montpellier-1, UFR de Medecine
                     address:
                        name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:David Guérit
               affiliation:
                     name:INSERM U844, CHU St Eloi, Bat INM
                     address:
                        name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                        type:PostalAddress
                     type:Organization
                     name:Université de Montpellier-1, UFR de Medecine
                     address:
                        name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniela Platano
               affiliation:
                     name:Istituto di ricerca Codivilla Putti
                     address:
                        name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Paul Chuchana
               affiliation:
                     name:INSERM U844, CHU St Eloi, Bat INM
                     address:
                        name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                        type:PostalAddress
                     type:Organization
                     name:Université de Montpellier-1, UFR de Medecine
                     address:
                        name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eleonora Olivotto
               affiliation:
                     name:Istituto di ricerca Codivilla Putti
                     address:
                        name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Francisco Espinoza
               affiliation:
                     name:INSERM U844, CHU St Eloi, Bat INM
                     address:
                        name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                        type:PostalAddress
                     type:Organization
                     name:Université de Montpellier-1, UFR de Medecine
                     address:
                        name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anne Dorandeu
               affiliation:
                     name:Service de Medecine légale CHU La Peyronie
                     address:
                        name:Service de Medecine légale CHU La Peyronie, Montpellier, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yves-Marie Pers
               affiliation:
                     name:INSERM U844, CHU St Eloi, Bat INM
                     address:
                        name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                        type:PostalAddress
                     type:Organization
                     name:Université de Montpellier-1, UFR de Medecine
                     address:
                        name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                        type:PostalAddress
                     type:Organization
                     name:thérapeutiques des maladies des os et articulations
                     address:
                        name:Unité clinique, thérapeutiques des maladies des os et articulations, Montpellier, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jacques Piette
               affiliation:
                     name:UMR5237, CNRS, CRBM
                     address:
                        name:UMR5237, CNRS, CRBM, Montpellier, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rosa Maria Borzi
               affiliation:
                     name:Istituto di ricerca Codivilla Putti
                     address:
                        name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christian Jorgensen
               affiliation:
                     name:INSERM U844, CHU St Eloi, Bat INM
                     address:
                        name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                        type:PostalAddress
                     type:Organization
                     name:Université de Montpellier-1, UFR de Medecine
                     address:
                        name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                        type:PostalAddress
                     type:Organization
                     name:thérapeutiques des maladies des os et articulations
                     address:
                        name:Unité clinique, thérapeutiques des maladies des os et articulations, Montpellier, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Danièle Noel
               affiliation:
                     name:INSERM U844, CHU St Eloi, Bat INM
                     address:
                        name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                        type:PostalAddress
                     type:Organization
                     name:Université de Montpellier-1, UFR de Medecine
                     address:
                        name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jean-Marc Brondello
               affiliation:
                     name:INSERM U844, CHU St Eloi, Bat INM
                     address:
                        name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                        type:PostalAddress
                     type:Organization
                     name:Université de Montpellier-1, UFR de Medecine
                     address:
                        name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis
      description:Recent evidence suggests that tissue accumulation of senescent p16INK4a-positive cells during the life span would be deleterious for tissue functions and could be the consequence of inherent age-associated disorders. Osteoarthritis (OA) is characterized by the accumulation of chondrocytes expressing p16INK4a and markers of the senescence-associated secretory phenotype (SASP), including the matrix remodeling metalloproteases MMP1/MMP13 and pro-inflammatory cytokines interleukin-8 (IL-8) and IL-6. Here, we evaluated the role of p16INK4a in the OA-induced SASP and its regulation by microRNAs (miRs). We used IL-1-beta-treated primary OA chondrocytes cultured in three-dimensional setting or mesenchymal stem cells differentiated into chondrocyte to follow p16INK4a expression. By transient transfection experiments and the use of knockout mice, we validate p16INK4a function in chondrocytes and its regulation by one miR identified by means of a genome-wide miR-array analysis. p16INK4a is induced upon IL-1-beta treatment and also during in vitro chondrogenesis. In the mouse model, Ink4a locus favors in vivo the proportion of terminally differentiated chondrocytes. When overexpressed in chondrocytes, p16INK4a is sufficient to induce the production of the two matrix remodeling enzymes, MMP1 and MMP13, thus linking senescence with OA pathogenesis and bone development. We identified miR-24 as a negative regulator of p16INK4a. Accordingly, p16INK4a expression increased while miR-24 level was repressed upon IL-1-beta addition, in OA cartilage and during in vitro terminal chondrogenesis. We disclosed herein a new role of the senescence marker p16INK4a and its regulation by miR-24 during OA and terminal chondrogenesis.
      datePublished:2014-02-27T00:00:00Z
      dateModified:2014-02-27T00:00:00Z
      pageStart:1
      pageEnd:12
      license:http://creativecommons.org/licenses/by/2.0/
      sameAs:https://doi.org/10.1186/ar4494
      keywords:
         Chondrogenic Differentiation
         Endochondral Ossification
         Primary Chondrocytes
         p16INK4a Expression
         Mature Chondrocytes
         Rheumatology
         Orthopedics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Far4494/MediaObjects/13075_2013_Article_4250_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Far4494/MediaObjects/13075_2013_Article_4250_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Far4494/MediaObjects/13075_2013_Article_4250_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Far4494/MediaObjects/13075_2013_Article_4250_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Far4494/MediaObjects/13075_2013_Article_4250_Fig5_HTML.jpg
      isPartOf:
         name:Arthritis Research & Therapy
         issn:
            1478-6362
         volumeNumber:16
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Didier Philipot
            affiliation:
                  name:INSERM U844, CHU St Eloi, Bat INM
                  address:
                     name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                     type:PostalAddress
                  type:Organization
                  name:Université de Montpellier-1, UFR de Medecine
                  address:
                     name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David Guérit
            affiliation:
                  name:INSERM U844, CHU St Eloi, Bat INM
                  address:
                     name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                     type:PostalAddress
                  type:Organization
                  name:Université de Montpellier-1, UFR de Medecine
                  address:
                     name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniela Platano
            affiliation:
                  name:Istituto di ricerca Codivilla Putti
                  address:
                     name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Paul Chuchana
            affiliation:
                  name:INSERM U844, CHU St Eloi, Bat INM
                  address:
                     name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                     type:PostalAddress
                  type:Organization
                  name:Université de Montpellier-1, UFR de Medecine
                  address:
                     name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eleonora Olivotto
            affiliation:
                  name:Istituto di ricerca Codivilla Putti
                  address:
                     name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Francisco Espinoza
            affiliation:
                  name:INSERM U844, CHU St Eloi, Bat INM
                  address:
                     name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                     type:PostalAddress
                  type:Organization
                  name:Université de Montpellier-1, UFR de Medecine
                  address:
                     name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anne Dorandeu
            affiliation:
                  name:Service de Medecine légale CHU La Peyronie
                  address:
                     name:Service de Medecine légale CHU La Peyronie, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yves-Marie Pers
            affiliation:
                  name:INSERM U844, CHU St Eloi, Bat INM
                  address:
                     name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                     type:PostalAddress
                  type:Organization
                  name:Université de Montpellier-1, UFR de Medecine
                  address:
                     name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                     type:PostalAddress
                  type:Organization
                  name:thérapeutiques des maladies des os et articulations
                  address:
                     name:Unité clinique, thérapeutiques des maladies des os et articulations, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jacques Piette
            affiliation:
                  name:UMR5237, CNRS, CRBM
                  address:
                     name:UMR5237, CNRS, CRBM, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rosa Maria Borzi
            affiliation:
                  name:Istituto di ricerca Codivilla Putti
                  address:
                     name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christian Jorgensen
            affiliation:
                  name:INSERM U844, CHU St Eloi, Bat INM
                  address:
                     name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                     type:PostalAddress
                  type:Organization
                  name:Université de Montpellier-1, UFR de Medecine
                  address:
                     name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                     type:PostalAddress
                  type:Organization
                  name:thérapeutiques des maladies des os et articulations
                  address:
                     name:Unité clinique, thérapeutiques des maladies des os et articulations, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Danièle Noel
            affiliation:
                  name:INSERM U844, CHU St Eloi, Bat INM
                  address:
                     name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                     type:PostalAddress
                  type:Organization
                  name:Université de Montpellier-1, UFR de Medecine
                  address:
                     name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jean-Marc Brondello
            affiliation:
                  name:INSERM U844, CHU St Eloi, Bat INM
                  address:
                     name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
                     type:PostalAddress
                  type:Organization
                  name:Université de Montpellier-1, UFR de Medecine
                  address:
                     name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Arthritis Research & Therapy
      issn:
         1478-6362
      volumeNumber:16
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:INSERM U844, CHU St Eloi, Bat INM
      address:
         name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
         type:PostalAddress
      name:Université de Montpellier-1, UFR de Medecine
      address:
         name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
         type:PostalAddress
      name:INSERM U844, CHU St Eloi, Bat INM
      address:
         name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
         type:PostalAddress
      name:Université de Montpellier-1, UFR de Medecine
      address:
         name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
         type:PostalAddress
      name:Istituto di ricerca Codivilla Putti
      address:
         name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
         type:PostalAddress
      name:INSERM U844, CHU St Eloi, Bat INM
      address:
         name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
         type:PostalAddress
      name:Université de Montpellier-1, UFR de Medecine
      address:
         name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
         type:PostalAddress
      name:Istituto di ricerca Codivilla Putti
      address:
         name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
         type:PostalAddress
      name:INSERM U844, CHU St Eloi, Bat INM
      address:
         name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
         type:PostalAddress
      name:Université de Montpellier-1, UFR de Medecine
      address:
         name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
         type:PostalAddress
      name:Service de Medecine légale CHU La Peyronie
      address:
         name:Service de Medecine légale CHU La Peyronie, Montpellier, France
         type:PostalAddress
      name:INSERM U844, CHU St Eloi, Bat INM
      address:
         name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
         type:PostalAddress
      name:Université de Montpellier-1, UFR de Medecine
      address:
         name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
         type:PostalAddress
      name:thérapeutiques des maladies des os et articulations
      address:
         name:Unité clinique, thérapeutiques des maladies des os et articulations, Montpellier, France
         type:PostalAddress
      name:UMR5237, CNRS, CRBM
      address:
         name:UMR5237, CNRS, CRBM, Montpellier, France
         type:PostalAddress
      name:Istituto di ricerca Codivilla Putti
      address:
         name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
         type:PostalAddress
      name:INSERM U844, CHU St Eloi, Bat INM
      address:
         name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
         type:PostalAddress
      name:Université de Montpellier-1, UFR de Medecine
      address:
         name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
         type:PostalAddress
      name:thérapeutiques des maladies des os et articulations
      address:
         name:Unité clinique, thérapeutiques des maladies des os et articulations, Montpellier, France
         type:PostalAddress
      name:INSERM U844, CHU St Eloi, Bat INM
      address:
         name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
         type:PostalAddress
      name:Université de Montpellier-1, UFR de Medecine
      address:
         name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
         type:PostalAddress
      name:INSERM U844, CHU St Eloi, Bat INM
      address:
         name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
         type:PostalAddress
      name:Université de Montpellier-1, UFR de Medecine
      address:
         name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Didier Philipot
      affiliation:
            name:INSERM U844, CHU St Eloi, Bat INM
            address:
               name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
               type:PostalAddress
            type:Organization
            name:Université de Montpellier-1, UFR de Medecine
            address:
               name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
               type:PostalAddress
            type:Organization
      name:David Guérit
      affiliation:
            name:INSERM U844, CHU St Eloi, Bat INM
            address:
               name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
               type:PostalAddress
            type:Organization
            name:Université de Montpellier-1, UFR de Medecine
            address:
               name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
               type:PostalAddress
            type:Organization
      name:Daniela Platano
      affiliation:
            name:Istituto di ricerca Codivilla Putti
            address:
               name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
               type:PostalAddress
            type:Organization
      name:Paul Chuchana
      affiliation:
            name:INSERM U844, CHU St Eloi, Bat INM
            address:
               name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
               type:PostalAddress
            type:Organization
            name:Université de Montpellier-1, UFR de Medecine
            address:
               name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
               type:PostalAddress
            type:Organization
      name:Eleonora Olivotto
      affiliation:
            name:Istituto di ricerca Codivilla Putti
            address:
               name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
               type:PostalAddress
            type:Organization
      name:Francisco Espinoza
      affiliation:
            name:INSERM U844, CHU St Eloi, Bat INM
            address:
               name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
               type:PostalAddress
            type:Organization
            name:Université de Montpellier-1, UFR de Medecine
            address:
               name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
               type:PostalAddress
            type:Organization
      name:Anne Dorandeu
      affiliation:
            name:Service de Medecine légale CHU La Peyronie
            address:
               name:Service de Medecine légale CHU La Peyronie, Montpellier, France
               type:PostalAddress
            type:Organization
      name:Yves-Marie Pers
      affiliation:
            name:INSERM U844, CHU St Eloi, Bat INM
            address:
               name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
               type:PostalAddress
            type:Organization
            name:Université de Montpellier-1, UFR de Medecine
            address:
               name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
               type:PostalAddress
            type:Organization
            name:thérapeutiques des maladies des os et articulations
            address:
               name:Unité clinique, thérapeutiques des maladies des os et articulations, Montpellier, France
               type:PostalAddress
            type:Organization
      name:Jacques Piette
      affiliation:
            name:UMR5237, CNRS, CRBM
            address:
               name:UMR5237, CNRS, CRBM, Montpellier, France
               type:PostalAddress
            type:Organization
      name:Rosa Maria Borzi
      affiliation:
            name:Istituto di ricerca Codivilla Putti
            address:
               name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
               type:PostalAddress
            type:Organization
      name:Christian Jorgensen
      affiliation:
            name:INSERM U844, CHU St Eloi, Bat INM
            address:
               name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
               type:PostalAddress
            type:Organization
            name:Université de Montpellier-1, UFR de Medecine
            address:
               name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
               type:PostalAddress
            type:Organization
            name:thérapeutiques des maladies des os et articulations
            address:
               name:Unité clinique, thérapeutiques des maladies des os et articulations, Montpellier, France
               type:PostalAddress
            type:Organization
      name:Danièle Noel
      affiliation:
            name:INSERM U844, CHU St Eloi, Bat INM
            address:
               name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
               type:PostalAddress
            type:Organization
            name:Université de Montpellier-1, UFR de Medecine
            address:
               name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
               type:PostalAddress
            type:Organization
      name:Jean-Marc Brondello
      affiliation:
            name:INSERM U844, CHU St Eloi, Bat INM
            address:
               name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
               type:PostalAddress
            type:Organization
            name:Université de Montpellier-1, UFR de Medecine
            address:
               name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
      name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
      name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
      name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
      name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
      name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
      name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
      name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
      name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
      name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
      name:Service de Medecine légale CHU La Peyronie, Montpellier, France
      name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
      name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
      name:Unité clinique, thérapeutiques des maladies des os et articulations, Montpellier, France
      name:UMR5237, CNRS, CRBM, Montpellier, France
      name:Laboratorio di immunoreumatologia e rigenerazione tissutale, IOR, Istituto di ricerca Codivilla Putti, Bologna, Italy
      name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
      name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
      name:Unité clinique, thérapeutiques des maladies des os et articulations, Montpellier, France
      name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
      name:Université de Montpellier-1, UFR de Medecine, Montpellier, France
      name:INSERM U844, CHU St Eloi, Bat INM, Montpellier, France
      name:Université de Montpellier-1, UFR de Medecine, Montpellier, France

External Links {🔗}(248)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

5.86s.