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We began analyzing https://www.nature.com/articles/ng1193-230, but it redirected us to https://www.nature.com/articles/ng1193-230. The analysis below is for the second page.

Title[redir]:
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma | Nature Genetics
Description:
We have examined the structure and expression of the products associated with the t(2;13)(q35;q14) translocation associated with alveolar rhabdomyosarcoma. The chromosome 13 gene (FKHR) is identified as a member of the fork head domain family of transcription factors characterized by a conserved DNA binding motif. Polymerase chain reaction analysis demonstrates that a 5′ PAX3–3′ FKHR chimaeric transcript is expressed in all eight alveolar rhabdomyosarcomas investigated. Immunoprecipitation experiments detect the predicted fusion protein. These findings indicate that the t(2;13) generates a potentially tumorigenic fusion transcription factor consisting of intact PAX3 DNA binding domains, a truncated fork head DNA binding domain and C–terminal FKHR regions.

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Keywords {🔍}

article, google, scholar, cas, pubmed, nature, gene, head, fork, domain, rhabdomyosarcoma, transcription, access, fusion, pax, genes, content, alveolar, binding, protein, factor, human, usa, cookies, family, dna, drosophila, privacy, expression, genet, central, data, genetics, tumour, barr, translocation, factors, open, paired, nuclear, dev, proc, natn, acad, sci, philadelphia, pennsylvania, molecular, research, advertising,

Topics {✒️}

nature portfolio permissions reprints privacy policy advertising nature genet social media dna-binding domain encoded nature 359 nature 363 nature hepatocyte-enriched transcription factor tissue-specific transcription factors development 118 rac1-mediated actin remodeling exhibits copy-number amplification pax3-foxo1 chromatin occupancy dna binding motif pax-foxo1 fusion proteins personal data springerlink instant access transcription factor family data protection fork head domain permissions chimaeric transcription factor human pax3 gene rna-binding protein privacy transcription factors characterized predicted fusion protein article galili journals search log minimal repression domain transcriptional activation domains jun proto-oncogene explore content alveolar rhabdomyosarcomas investigated subscription content telencephalon-restricted expression eukaryotic transcription factors mammalian transcription factors isolated human genes european economic area immunoprecipitation experiments detect institutional subscriptions read axial pattern formation klein-waardenburg syndrome waardenburg syndrome type höltingflorencia cidre-aranazmaximilian highly sensitive approach

Questions {❓}

The fork head domain: A novel DNA binding motif of eukaryotic transcription factors?

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