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Title[redir]:
Genome-wide association study of Arabidopsis thaliana leaf microbial community | Nature Communications
Description:
Identifying the factors that influence the outcome of host–microbial interactions is critical to protecting biodiversity, minimizing agricultural losses and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbe numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis. The effect of a host
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article, community, google, scholar, bacterial, cas, gwas, microbial, thaliana, species, plant, fungal, communities, otus, nature, host, results, leaf, genomewide, association, arabidopsis, gene, samples, number, bacteria, supplementary, data, variation, sequencing, ads, cell, table, top, fungi, genetic, analyses, diversity, dna, reads, genes, accessions, sample, sequenced, cca, structure, field, loci, studies, methods, fig,
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headline:Genome-wide association study of Arabidopsis thaliana leaf microbial community
description:Identifying the factors that influence the outcome of hostâmicrobial interactions is critical to protecting biodiversity, minimizing agricultural losses and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbe numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis. The effect of a host's genetic variation on the structure of its microbial community is poorly understood. Here, Horton et al. reveal associations between genetic variants in the plant model species Arabidopsis thalianaand the composition of the leaves' microbial communities.
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