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      headline:Genetically and functionally defined NTS to PBN brain circuits mediating anorexia
      description:The central nervous system controls food consumption to maintain metabolic homoeostasis. In response to a meal, visceral signals from the gut activate neurons in the nucleus of the solitary tract (NTS) via the vagus nerve. These NTS neurons then excite brain regions known to mediate feeding behaviour, such as the lateral parabrachial nucleus (PBN). We previously described a neural circuit for appetite suppression involving calcitonin gene-related protein (CGRP)-expressing PBN (CGRPPBN) neurons; however, the molecular identity of the inputs to these neurons was not established. Here we identify cholecystokinin (CCK) and noradrenergic, dopamine β-hydroxylase (DBH)-expressing NTS neurons as two separate populations that directly excite CGRPPBN neurons. When these NTS neurons are activated using optogenetic or chemogenetic methods, food intake decreases and with chronic stimulation mice lose body weight. Our optogenetic results reveal that CCK and DBH neurons in the NTS directly engage CGRPPBN neurons to promote anorexia. Neurons in the nucleus of the solitary tract (NTS) are known to receive visceral signals from the gut during feeding. Here, the authors identify two populations of CCK- and DBH-expressing NTS neurons that work to suppress food intake when activated via opto- or chemogenetic stimulation.
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• What are the total earnings of https://doi.org/10.1016%2F0006-8993%2888%2990654-3?
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• How much cash flow does https://doi.org/10.1016%2F0306-4522%2888%2990326-0 have monthly?
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• https://doi.org/10.1152%2Fajpregu.00556.2010 income
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=Hindbrain%20noradrenergic%20A2%20neurons%3A%20diverse%20roles%20in%20autonomic%2C%20endocrine%2C%20cognitive%2C%20and%20behavioral%20functions&journal=Am.%20J.%20Physiol.%20Regul.%20Integr.%20Comp.%20Physiol.&doi=10.1152%2Fajpregu.00556.2010&volume=300&pages=R222-R235&publication_year=2011&author=Rinaman%2CL
• https://doi.org/10.1073%2Fpnas.0700293104 income
• Monthly income for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2007PNAS..104.5163A
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• How much does https://doi.org/10.1016%2F0306-4522%2886%2990040-0 bring in each month?
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• Earnings of https://doi.org/10.1523%2FJNEUROSCI.3502-07.2007
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Visceral%20afferents%20directly%20activate%20catecholamine%20neurons%20in%20the%20solitary%20tract%20nucleus&journal=J.%20Neurosci.&doi=10.1523%2FJNEUROSCI.3502-07.2007&volume=27&pages=13292-13302&publication_year=2007&author=Appleyard%2CSM
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• What's the financial intake of https://doi.org/10.1113%2Fjphysiol.2013.261289?
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• How much does https://doi.org/10.1016%2Fj.neuron.2009.06.014 gross monthly?
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• What's the profit of http://scholar.google.com/scholar_lookup?&title=CNS%20origins%20of%20the%20sympathetic%20nervous%20system%20outflow%20to%20brown%20adipose%20tissue&journal=Am.%20J.%20Physiol.&volume=276&pages=R1569-R1578&publication_year=1999&author=Bamshad%2CM&author=Song%2CCK&author=Bartness%2CTJ?
• What's the total monthly financial gain of https://doi.org/10.1016%2Fj.neuroscience.2014.10.043?
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• What's the monthly money flow for https://doi.org/10.1016%2Fj.bbr.2008.07.039?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009uhfl.book.....L net monthly?
• Earnings of http://scholar.google.com/scholar_lookup?&title=Distribution%20and%20neurochemical%20characterization%20of%20neurons%20within%20the%20nucleus%20of%20the%20solitary%20tract%20responsive%20to%20serotonin%20agonist-induced%20hypophagia&journal=Behav.%20Brain%20Res.&doi=10.1016%2Fj.bbr.2008.07.039&volume=196&pages=139-143&publication_year=2009&author=Lam%2CDD
• Discover the revenue of https://doi.org/10.1152%2Fajpregu.00065.2015
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• How much does https://doi.org/10.1369%2Fjhc.7A7331.2007 earn?
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• https://doi.org/10.1523%2FJNEUROSCI.2742-12.2013's revenue stream
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Acute%20and%20long-term%20suppression%20of%20feeding%20behaviour%20by%20POMC%20neurons%20in%20the%20brainstem%20and%20hypothalamus%2C%20respectively&journal=J.%20Neurosci.&doi=10.1523%2FJNEUROSCI.2742-12.2013&volume=33&pages=3624-3632&publication_year=2013&author=Zhan%2CC
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• https://doi.org/10.1002%2Fcne.20823's financial summary
• How much does http://scholar.google.com/scholar_lookup?&title=Expression%20of%20ghrelin%20receptor%20mRNA%20in%20the%20rat%20and%20the%20mouse%20brain&journal=J.%20Comp.%20Neurol.&doi=10.1002%2Fcne.20823&volume=494&pages=528-548&publication_year=2006&author=Zigman%2CJM&author=Jones%2CJE&author=Lee%2CCE&author=Saper%2CCB&author=Elmquist%2CJK gross monthly?
• What's the financial gain of https://doi.org/10.1016%2FS0006-8993%2899%2901153-1?
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• Financial intake of https://doi.org/10.1002%2Fcne.902910209
• What's the revenue for http://scholar.google.com/scholar_lookup?&title=Inhibin%20beta%2C%20somatostatin%2C%20and%20enkephalin%20immunoreactivities%20coexist%20in%20caudal%20medullary%20neurons%20that%20project%20to%20the%20paraventricular%20nucleus%20of%20the%20hypothalamus&journal=J.%20Comp.%20Neurol.&doi=10.1002%2Fcne.902910209&volume=291&pages=269-280&publication_year=1990&author=Sawchenko%2CPE&author=Arias%2CC&author=Bittencourt%2CJC?
• https://doi.org/10.1016%2FS0306-4522%2896%2900434-4 income
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• What's the profit of https://doi.org/10.1038%2F35053509?
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• How much income does https://doi.org/10.1016%2Fj.cell.2015.05.057 have?
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• How much does http://scholar.google.com/scholar_lookup?&title=Appetite%20controlled%20by%20a%20cholecystokinin%20nucleus%20of%20the%20solitary%20tract%20to%20hypothalamus%20neurocircuit&journal=Elife&doi=10.7554%2FeLife.12225&volume=5&publication_year=2016&author=D%27Agostino%2CG pull in monthly?
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• What's the monthly money flow for https://doi.org/10.1016%2F0016-5085%2895%2990601-0?
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• Profit of https://doi.org/10.1291%2Fhypres.29.951
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• What's https://doi.org/10.1016%2Fj.neuron.2011.07.026's gross income?
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• Check the income stats for https://doi.org/10.1371%2Fjournal.pone.0008047
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009PLoSO...4.8047S pull in monthly?
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