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We began analyzing https://www.nature.com/articles/nature03205, but it redirected us to https://www.nature.com/articles/nature03205. The analysis below is for the second page.

Title[redir]:
Regulation of cap-dependent translation by eIF4E inhibitory proteins | Nature
Description:
Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5′ ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation. A living cell only ever expresses a fraction of the genes within its DNA at one time; in eukaryotes, particularly, much of the genome is irrelevant. But even for the messenger RNAs that are synthesized, expression as a protein is not always immediate. They can be held in the cytoplasm, and activated when needed by the binding of the initiation factor eIF4E to the modified guanosine ‘cap’ at their 5′ ends. Joel Richter and Nahum Sonenberg review recent research on this system, which controls processes as diverse as development, cell growth and tumour formation.

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Education
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Science

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Keywords {🔍}

article, scholar, google, cas, nature, translation, cell, eife, protein, sonenberg, factor, initiation, mrna, access, richter, translational, cancer, content, binding, biol, cookies, regulation, capdependent, cap, growth, embo, privacy, proteins, genes, synaptic, research, data, journal, joel, eukaryotic, mrnas, structure, open, cells, rev, complex, ads, synapses, signaling, advertising, information, subscribe, nahum, messenger, requires,

Topics {✒️}

nature portfolio permissions reprints privacy policy health research creb-mediated long-term facilitation advertising eukaryotic initiation factor-4e social media translation factor eif-4γ author information authors nature struct nature med nature rev proline-rich homeodomain protein long-term synaptic plasticity cell cycle-dependent phosphorylation nature 345 nature 428 nature 433 nature author correspondence translational inhibitor 4e-bp1 cap-dependent translation smaug-mediated translational repression personal data springerlink instant access cpeb-mediated cytoplasmic polyadenylation experience-dependent translation data protection permissions 4e-binding protein 4e-binding protein 1 european economic area messenger rnas cap-binding protein initiation factor eif4e intracellular mrna transport development eif4e binding protein eif4e-binding protein international scholar program common motif shared eif4 initiation factors α-camkii mrna αcamkii mrna polyadenylation privacy eif-4f local protein synthesis rate-limiting factor translation complex eif4f

Questions {❓}

Does the ribosome translate cancer?
Synaptic tagging–who's it?
Will mTOR inhibitors make it as cancer drugs?

Schema {🗺️}

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