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Title[redir]:
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis | Nature
Description:
The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor and regulator of interactions between T cells and dendritic cells in vitro. Mice with a disrupted opgl gene show severe osteopetrosis and a defect in tooth eruption, and completely lack osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis. Although dendritic cells appear normal, opgl-deficient mice exhibit defects in early differentiation of T and B lymphocytes. Surprisingly, opgl-deficient mice lack all lymph nodes but have normal splenic structure and Peyer
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article, google, scholar, cas, nature, cell, mice, development, cells, bone, ads, factor, access, med, osteoclast, receptor, content, ligand, differentiation, dendritic, osteopetrosis, science, exp, cookies, usa, lymphotoxin, privacy, function, opgl, regulator, lymphocyte, organogenesis, yoshida, open, tnf, lymphoid, amgen, data, pathophysiology, pubmed, proc, natl, acad, sci, alpha, immunity, research, advertising, information, journal,
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nature portfolio permissions reprints privacy policy c-src proto-oncogene leads editing granulocyte/macrophage colony-stimulating factor advertising social media subscribe nature nature med author information authors nature 345 nature 390 nature 375 nature 397 nature author correspondence osteoclast-macrophage lineage determination interleukin-7 receptor-deficient mice osteoprotegerin/osteoclastogenesis-inhibitory factor tnf alpha-deficient mice personal data mice lacking nf-kappab1 colony-stimulating factor 1 cd1+relb+ dendritic cells springerlink instant access opgl-deficient mice lack lymphotoxin beta-deficient mice data protection permissions dendritic-cell function humoral immune response lymph-node organogenesis small-molecule amines osteoclast differentiation factor lymphotoxin Ξ² receptor b-cell development local microenvironment provided privacy secreted protein involved delayed hematopoietic development lymph node genesis regulates osteoclast differentiation macrophage-deficient osteopetrotic mutant rag-1β/β mice oral health outcomes explore content subscription content article kong cell receptor signaling
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description:The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor and regulator of interactions between T cells and dendritic cells in vitro. Mice with a disrupted opgl gene show severe osteopetrosis and a defect in tooth eruption, and completely lack osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis. Although dendritic cells appear normal, opgl-deficient mice exhibit defects in early differentiation of T and B lymphocytes. Surprisingly, opgl-deficient mice lack all lymph nodes but have normal splenic structure and Peyer's patches. Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
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