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We are analyzing https://www.nature.com/articles/16852.

Title:
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis | Nature
Description:
The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor and regulator of interactions between T cells and dendritic cells in vitro. Mice with a disrupted opgl gene show severe osteopetrosis and a defect in tooth eruption, and completely lack osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis. Although dendritic cells appear normal, opgl-deficient mice exhibit defects in early differentiation of T and B lymphocytes. Surprisingly, opgl-deficient mice lack all lymph nodes but have normal splenic structure and Peyer
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {πŸ“š}

  • Education
  • Science
  • Telecommunications

Content Management System {πŸ“}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

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πŸŒ† Monumental Traffic: 20M - 50M visitors per month


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Display Ads {🎯}


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Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
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How Much Does Nature.com Make? {πŸ’°}


Display Ads {🎯}

$536,300 per month
Estimations show Nature.com's display ad online revenue falls between $357,503 and $983,134 per month.

Keywords {πŸ”}

article, google, scholar, cas, nature, cell, mice, development, cells, bone, ads, factor, access, med, osteoclast, receptor, content, ligand, differentiation, dendritic, osteopetrosis, science, exp, cookies, usa, lymphotoxin, privacy, function, opgl, regulator, lymphocyte, organogenesis, yoshida, open, tnf, lymphoid, amgen, data, pathophysiology, pubmed, proc, natl, acad, sci, alpha, immunity, research, advertising, information, journal,

Topics {βœ’οΈ}

nature portfolio permissions reprints privacy policy c-src proto-oncogene leads editing granulocyte/macrophage colony-stimulating factor advertising social media subscribe nature nature med author information authors nature 345 nature 390 nature 375 nature 397 nature author correspondence osteoclast-macrophage lineage determination interleukin-7 receptor-deficient mice osteoprotegerin/osteoclastogenesis-inhibitory factor tnf alpha-deficient mice personal data mice lacking nf-kappab1 colony-stimulating factor 1 cd1+relb+ dendritic cells springerlink instant access opgl-deficient mice lack lymphotoxin beta-deficient mice data protection permissions dendritic-cell function humoral immune response lymph-node organogenesis small-molecule amines osteoclast differentiation factor lymphotoxin Ξ² receptor b-cell development local microenvironment provided privacy secreted protein involved delayed hematopoietic development lymph node genesis regulates osteoclast differentiation macrophage-deficient osteopetrotic mutant rag-1βˆ’/βˆ’ mice oral health outcomes explore content subscription content article kong cell receptor signaling

Schema {πŸ—ΊοΈ}

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               name:Departments of Cell Biology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
               type:PostalAddress
            type:Organization
      name:Casey Capparelli
      affiliation:
            name:Amgen Inc., One Amgen Center Drive
            address:
               name:Departments of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
               type:PostalAddress
            type:Organization
      name:Sean Morony
      affiliation:
            name:Amgen Inc., One Amgen Center Drive
            address:
               name:Departments of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
               type:PostalAddress
            type:Organization
      name:Antonio J. Oliveira-dos-Santos
      affiliation:
            name:Ontario Cancer Institute, University of Toronto
            address:
               name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Gwyneth Van
      affiliation:
            name:Amgen Inc., One Amgen Center Drive
            address:
               name:Departments of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
               type:PostalAddress
            type:Organization
      name:Annick Itie
      affiliation:
            name:Ontario Cancer Institute, University of Toronto
            address:
               name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Wilson Khoo
      affiliation:
            name:Ontario Cancer Institute, University of Toronto
            address:
               name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Andrew Wakeham
      affiliation:
            name:Ontario Cancer Institute, University of Toronto
            address:
               name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Colin R. Dunstan
      affiliation:
            name:Amgen Inc., One Amgen Center Drive
            address:
               name:Departments of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
               type:PostalAddress
            type:Organization
      name:David L. Lacey
      affiliation:
            name:Amgen Inc., One Amgen Center Drive
            address:
               name:Departments of Cell Biology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
               type:PostalAddress
            type:Organization
      name:Tak W. Mak
      affiliation:
            name:Ontario Cancer Institute, University of Toronto
            address:
               name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:William J. Boyle
      affiliation:
            name:Amgen Inc., One Amgen Center Drive
            address:
               name:Departments of Cell Biology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
               type:PostalAddress
            type:Organization
      name:Josef M. Penninger
      affiliation:
            name:Ontario Cancer Institute, University of Toronto
            address:
               name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
      name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
      name:Departments of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
      name:Departments of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
      name:Departments of Cell Biology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
      name:Departments of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
      name:Departments of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
      name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
      name:Departments of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
      name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
      name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
      name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
      name:Departments of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
      name:Departments of Cell Biology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
      name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
      name:Departments of Cell Biology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, USA
      name:Amgen Institute, and the Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, University of Toronto, Toronto, Canada
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