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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
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  14. CDN Services

We began analyzing https://www.nature.com/articles/ni.3005, but it redirected us to https://www.nature.com/articles/ni.3005. The analysis below is for the second page.

Title[redir]:
Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages | Nature Immunology
Description:
Details of the ontogeny of alveolar macrophages remain unclear. Kopf and colleagues show that fetal monocytes give rise to alveolar macrophages in a manner dependent on the nuclear receptor PPAR-γ and the cytokine GM-CSF. Tissue-resident macrophages constitute heterogeneous populations with unique functions and distinct gene-expression signatures. While it has been established that they originate mostly from embryonic progenitor cells, the signals that induce a characteristic tissue-specific differentiation program remain unknown. We found that the nuclear receptor PPAR-γ determined the perinatal differentiation and identity of alveolar macrophages (AMs). In contrast, PPAR-γ was dispensable for the development of macrophages located in the peritoneum, liver, brain, heart, kidneys, intestine and fat. Transcriptome analysis of the precursors of AMs from newborn mice showed that PPAR-γ conferred a unique signature, including several transcription factors and genes associated with the differentiation and function of AMs. Expression of PPAR-γ in fetal lung monocytes was dependent on the cytokine GM-CSF. Therefore, GM-CSF has a lung-specific role in the perinatal development of AMs through the induction of PPAR-γ in fetal monocytes.

Matching Content Categories {📚}

  • Education
  • Science
  • Technology & Computing

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Doi.org might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, google, scholar, cas, macrophages, nature, pparγ, mice, central, cells, alveolar, monocytes, expression, article, macrophage, immunol, development, access, supplementary, mouse, cell, ppargflfl, group, data, receptor, tissue, content, fetal, immunity, adult, representative, cdccreppargflfl, analysis, differentiation, nat, zurich, institute, experiments, cookies, genes, peroxisome, proliferatoractivated, cytometry, analyzed, figure, plots, experiment, privacy, information, immunology,

Topics {✒️}

nature portfolio permissions reprints peroxisome proliferator-activated receptor-γ privacy policy specific gene-expression profile open-source system distinct gene-expression signatures advertising gene-expression profiles social media content fate ppar-titioning nuclear receptor ppar-γ nature 391 nature 493 nature 457 nature conditional gene targeting rosa26-stopflox-tdrfp mice43 quantitative real-time pcr controls dectin-1-dependent development stroma-derived interleukin-34 controls author correspondence monocyte-derived alveolar macrophages springerlink instant access survey steady-state tissues yolk sac-derived macrophages molecular health sciences lymphoid specific expression tissue-resident macrophages permissions article schneider cd11ccreppargfl/fl cells compared arrested immature cd11ccreppargfl/fl immature arrested cd11ccreppargfl/fl ppar-γ conferred macrophage populations alveolar macrophage function colony stimulating factors bar graphs display microarray data management ef780–cd45+cd64+autofluorescence+ white adipose tissue privacy article purchase peritoneal macrophage signature alveolar macrophages develop extracellular vesicles derived monocyte inflammatory cytokines tissue-restricted ligand present address

Schema {🗺️}

WebPage:
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         headline:Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages
         description:Details of the ontogeny of alveolar macrophages remain unclear. Kopf and colleagues show that fetal monocytes give rise to alveolar macrophages in a manner dependent on the nuclear receptor PPAR-γ and the cytokine GM-CSF. Tissue-resident macrophages constitute heterogeneous populations with unique functions and distinct gene-expression signatures. While it has been established that they originate mostly from embryonic progenitor cells, the signals that induce a characteristic tissue-specific differentiation program remain unknown. We found that the nuclear receptor PPAR-γ determined the perinatal differentiation and identity of alveolar macrophages (AMs). In contrast, PPAR-γ was dispensable for the development of macrophages located in the peritoneum, liver, brain, heart, kidneys, intestine and fat. Transcriptome analysis of the precursors of AMs from newborn mice showed that PPAR-γ conferred a unique signature, including several transcription factors and genes associated with the differentiation and function of AMs. Expression of PPAR-γ in fetal lung monocytes was dependent on the cytokine GM-CSF. Therefore, GM-CSF has a lung-specific role in the perinatal development of AMs through the induction of PPAR-γ in fetal monocytes.
         datePublished:2014-09-28T00:00:00Z
         dateModified:2014-09-28T00:00:00Z
         pageStart:1026
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            Biomedicine
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      headline:Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages
      description:Details of the ontogeny of alveolar macrophages remain unclear. Kopf and colleagues show that fetal monocytes give rise to alveolar macrophages in a manner dependent on the nuclear receptor PPAR-γ and the cytokine GM-CSF. Tissue-resident macrophages constitute heterogeneous populations with unique functions and distinct gene-expression signatures. While it has been established that they originate mostly from embryonic progenitor cells, the signals that induce a characteristic tissue-specific differentiation program remain unknown. We found that the nuclear receptor PPAR-γ determined the perinatal differentiation and identity of alveolar macrophages (AMs). In contrast, PPAR-γ was dispensable for the development of macrophages located in the peritoneum, liver, brain, heart, kidneys, intestine and fat. Transcriptome analysis of the precursors of AMs from newborn mice showed that PPAR-γ conferred a unique signature, including several transcription factors and genes associated with the differentiation and function of AMs. Expression of PPAR-γ in fetal lung monocytes was dependent on the cytokine GM-CSF. Therefore, GM-CSF has a lung-specific role in the perinatal development of AMs through the induction of PPAR-γ in fetal monocytes.
      datePublished:2014-09-28T00:00:00Z
      dateModified:2014-09-28T00:00:00Z
      pageStart:1026
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         Infectious Diseases
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Social Networks {👍}(1)

External Links {🔗}(293)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

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