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Keywords {🔍}

tumour, data, immune, stromal, cancer, cell, cells, article, expression, purity, estimate, scores, google, scholar, samples, gene, cas, genes, types, ovarian, tcga, supplementary, fig, nature, high, analysis, sets, score, signature, set, infiltrating, normal, fraction, carcinoma, tissue, affymetrix, based, breast, lung, mutation, human, number, tumours, signatures, copy, microarray, algorithm, absolute, genome, sample,

Topics {✒️}

nature portfolio /partners_programs/programs/developer/tools/powertools privacy policy open-source package advertising tcga research network tcga data portal fibroblast/mesenchymal nature gynecology service social media r-library author information authors language 0/ reprints data analysis tools rna-seq-based transcriptome profiles clear-cell renal carcinoma apt-probeset-genotype files cholestasis-induced phenotypic transformation benjamini–hochberg fdr correction resulting apt-probeset-summarize author correspondence affymetrix ht-hg-u133a microbead-based cell sorting cancer-type-specific manner4 genome-wide association scans gene set-enrichment analysis nature 487 nature 462 nature 455 nature 474 nature 490 nature 489 nature 497 nature 483 nature small-cell lung cancer low-purity group compared adipose differentiation-related protein low-purity cases suggests hr + /her2− breast cancer gov/docs/publications/unified_expression/ selected single-nucleotide alterations supplementary figs s2–s6 adoptive t-cell therapies epcam-negative cell fractions cell-type-specific profiles histopathologic-based prognostic factors low-purity groups based laser-capture microdissection compared

Questions {❓}

• Stromal cells in the tumor microenvironment: accomplices of tumor progression?

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      headline:Inferring tumour purity and stromal and immune cell admixture from expression data
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      name:Wandaliz Torres-Garcia
      affiliation:
            name:The University of Texas MD Anderson Cancer Centre
            address:
               name:Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
               type:PostalAddress
            type:Organization
      name:Victor Treviño
      affiliation:
            name:Catedra de Bioinformatica, Tecnologico de Monterrey, Campus Monterrey
            address:
               name:Catedra de Bioinformatica, Tecnologico de Monterrey, Campus Monterrey, Monterrey, Mexico
               type:PostalAddress
            type:Organization
      name:Hui Shen
      affiliation:
            name:USC Epigenome Centre, University of Southern California
            address:
               name:USC Epigenome Centre, University of Southern California,
               type:PostalAddress
            type:Organization
            name:Los Angeles
            address:
               name:Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Peter W. Laird
      affiliation:
            name:USC Epigenome Centre, University of Southern California
            address:
               name:USC Epigenome Centre, University of Southern California,
               type:PostalAddress
            type:Organization
            name:Los Angeles
            address:
               name:Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Douglas A. Levine
      affiliation:
            name:Gynecology Service, Memorial Sloan-Kettering Cancer Centre
            address:
               name:Department of Surgery, Gynecology Service, Memorial Sloan-Kettering Cancer Centre, New York, USA
               type:PostalAddress
            type:Organization
      name:Scott L. Carter
      affiliation:
            name:The Broad Institute of Harvard and MIT
            address:
               name:The Broad Institute of Harvard and MIT, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Gad Getz
      affiliation:
            name:The Broad Institute of Harvard and MIT
            address:
               name:The Broad Institute of Harvard and MIT, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Katherine Stemke-Hale
      affiliation:
            name:The University of Texas MD Anderson Cancer Centre
            address:
               name:Department of Systems Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
               type:PostalAddress
            type:Organization
      name:Gordon B. Mills
      affiliation:
            name:The University of Texas MD Anderson Cancer Centre
            address:
               name:Department of Systems Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
               type:PostalAddress
            type:Organization
      name:Roel G.W. Verhaak
      affiliation:
            name:The University of Texas MD Anderson Cancer Centre
            address:
               name:Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
      name:Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
      name:Department of Systems Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
      name:Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
      name:Catedra de Bioinformatica, Tecnologico de Monterrey, Campus Monterrey, Monterrey, Mexico
      name:Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
      name:Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
      name:Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
      name:Catedra de Bioinformatica, Tecnologico de Monterrey, Campus Monterrey, Monterrey, Mexico
      name:USC Epigenome Centre, University of Southern California,
      name:Los Angeles, USA
      name:USC Epigenome Centre, University of Southern California,
      name:Los Angeles, USA
      name:Department of Surgery, Gynecology Service, Memorial Sloan-Kettering Cancer Centre, New York, USA
      name:The Broad Institute of Harvard and MIT, Cambridge, USA
      name:The Broad Institute of Harvard and MIT, Cambridge, USA
      name:Department of Systems Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
      name:Department of Systems Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA
      name:Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Centre, Houston, USA

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