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We began analyzing https://www.nature.com/articles/nature14666, but it redirected us to https://www.nature.com/articles/nature14666. The analysis below is for the second page.

Title[redir]:
Non-coding recurrent mutations in chronic lymphocytic leukaemia | Nature
Description:
Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of the genomic landscape of 452 CLL cases and 54 patients with monoclonal B-lymphocytosis, a precursor disorder. We extend the number of CLL driver alterations, including changes in ZNF292, ZMYM3, ARID1A and PTPN11. We also identify novel recurrent mutations in non-coding regions, including the 3′ region of NOTCH1, which cause aberrant splicing events, increase NOTCH1 activity and result in a more aggressive disease. In addition, mutations in an enhancer located on chromosome 9p13 result in reduced expression of the B-cell-specific transcription factor PAX5. The accumulative number of driver alterations (0 to ≥4) discriminated between patients with differences in clinical behaviour. This study provides an integrated portrait of the CLL genomic landscape, identifies new recurrent driver mutations of the disease, and suggests clinical interventions that may improve the management of this neoplasia. Genomic approaches in more than 500 patients are used to extend the number of chronic lymphocytic leukaemia (CLL) driver alterations, and also identify novel recurrent mutations in non-coding regions, including an enhancer of PAX5 and the 3′ untranslated region of NOTCH1, which lead to aberrant splicing events, increased NOTCH1 protein stability and activity, and an adverse clinical outcome. This paper from the International Cancer Genomic Consortium reports the results of a number of genomic approaches used to characterize chronic lymphocytic leukaemia and its precursor in more than 500 patients. As well as extending the number of chronic lymphocytic leukaemia driver alterations found in the coding portion of the genome, the study identies novel recurrent mutations in non-coding regions, including the 3′ UTR of NOTCH1, which cause aberrant splicing events, an increase in NOTCH1 activity and more aggressive disease, as well as mutations in an enhancer which result in reduced expression of the B-cell-specific transcription factor PAX5.

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Keywords {🔍}

article, google, scholar, cas, lymphocytic, mutations, chronic, nature, cll, leukemia, data, analysis, cancer, cases, notch, cells, number, expression, pax, spain, recurrent, patients, barcelona, genomic, extended, gene, mbl, enhancer, rearrangements, red, chromosome, access, case, leukaemia, alterations, clinical, sequencing, genes, genome, shown, blue, detected, chromosomes, molecular, dna, ighv, research, samples, bcl, puente,

Topics {✒️}

crispr-cas9 genome editing permissions reprints nature portfolio privacy policy advertising generating libraries cancer development social media middle row stereotyped b-cell receptors sequence alignment/map format estudis avançats-academia investigators research unit universidad de salamanca-csic carlos lópez-otín rna-seq reads supporting full size image european genome-phenome archive extended data figures high-resolution genomic profiling crispr/cas9-induced mutations crispr/cas9-introduced mutations research nature methods 4 nature methods 9 nature methods 11 nature rev nature genet nature biotechnol nature immunol richter syndrome erin pax5-enhancer-mutated lymphoblastoid recurrently mutated enhancer poor-prognostic stereotyped subsets permissions springerlink instant access extended data fig exome sequencing data genotyping array data chronic lymphocytic leukaemia tumor incidence data b-cell differentiation immunoglobulin-variable-region mutations mónica lópez-guerra universidad de deusto nature 475 nature 464 nature 500 nature 412 nature 499

Schema {🗺️}

WebPage:
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         headline:Non-coding recurrent mutations in chronic lymphocytic leukaemia
         description:Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of the genomic landscape of 452 CLL cases and 54 patients with monoclonal B-lymphocytosis, a precursor disorder. We extend the number of CLL driver alterations, including changes in ZNF292, ZMYM3, ARID1A and PTPN11. We also identify novel recurrent mutations in non-coding regions, including the 3′ region of NOTCH1, which cause aberrant splicing events, increase NOTCH1 activity and result in a more aggressive disease. In addition, mutations in an enhancer located on chromosome 9p13 result in reduced expression of the B-cell-specific transcription factor PAX5. The accumulative number of driver alterations (0 to ≥4) discriminated between patients with differences in clinical behaviour. This study provides an integrated portrait of the CLL genomic landscape, identifies new recurrent driver mutations of the disease, and suggests clinical interventions that may improve the management of this neoplasia. Genomic approaches in more than 500 patients are used to extend the number of chronic lymphocytic leukaemia (CLL) driver alterations, and also identify novel recurrent mutations in non-coding regions, including an enhancer of PAX5 and the 3′ untranslated region of NOTCH1, which lead to aberrant splicing events, increased NOTCH1 protein stability and activity, and an adverse clinical outcome. This paper from the International Cancer Genomic Consortium reports the results of a number of genomic approaches used to characterize chronic lymphocytic leukaemia and its precursor in more than 500 patients. As well as extending the number of chronic lymphocytic leukaemia driver alterations found in the coding portion of the genome, the study identies novel recurrent mutations in non-coding regions, including the 3′ UTR of NOTCH1, which cause aberrant splicing events, an increase in NOTCH1 activity and more aggressive disease, as well as mutations in an enhancer which result in reduced expression of the B-cell-specific transcription factor PAX5.
         datePublished:2015-07-22T00:00:00Z
         dateModified:2015-10-22T00:00:00Z
         pageStart:519
         pageEnd:524
         sameAs:https://doi.org/10.1038/nature14666
         keywords:
            Cancer
            Science
            Humanities and Social Sciences
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         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:526
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                     name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
                     address:
                        name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kostas Stamatopoulos
               affiliation:
                     name:Institute of Applied Biosciences, Center for Research and Technology Hellas
                     address:
                        name:Institute of Applied Biosciences, Center for Research and Technology Hellas, Thermi, Greece
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hendrik G. Stunnenberg
               affiliation:
                     name:Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen
                     address:
                        name:Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:David Tamborero
               affiliation:
                     name:Research Unit on Biomedical Informatics, Universitat Pompeu Fabra
                     address:
                        name:Department of Experimental and Health Sciences, Research Unit on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:María J. Terol
               affiliation:
                     name:Servicio de Hematología, Hospital Clínico de Valencia
                     address:
                        name:Servicio de Hematología, Hospital Clínico de Valencia, Valencia, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alfonso Valencia
               affiliation:
                     name:Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Spanish National Bioinformatics Institute
                     address:
                        name:Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Spanish National Bioinformatics Institute, Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nuria López-Bigas
               affiliation:
                     name:Research Unit on Biomedical Informatics, Universitat Pompeu Fabra
                     address:
                        name:Department of Experimental and Health Sciences, Research Unit on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:David Torrents
               affiliation:
                     name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
                     address:
                        name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ivo Gut
               affiliation:
                     name:Centro Nacional de Análisis Genómico, Parc Científic de Barcelona
                     address:
                        name:Centro Nacional de Análisis Genómico, Parc Científic de Barcelona, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Armando López-Guillermo
               affiliation:
                     name:Servicio de Hematología, Hospital Clínic, IDIBAPS
                     address:
                        name:Servicio de Hematología, Hospital Clínic, IDIBAPS, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carlos López-Otín
               affiliation:
                     name:Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo
                     address:
                        name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Elías Campo
               affiliation:
                     name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
                     address:
                        name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               email:[email protected]
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ScholarlyArticle:
      headline:Non-coding recurrent mutations in chronic lymphocytic leukaemia
      description:Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of the genomic landscape of 452 CLL cases and 54 patients with monoclonal B-lymphocytosis, a precursor disorder. We extend the number of CLL driver alterations, including changes in ZNF292, ZMYM3, ARID1A and PTPN11. We also identify novel recurrent mutations in non-coding regions, including the 3′ region of NOTCH1, which cause aberrant splicing events, increase NOTCH1 activity and result in a more aggressive disease. In addition, mutations in an enhancer located on chromosome 9p13 result in reduced expression of the B-cell-specific transcription factor PAX5. The accumulative number of driver alterations (0 to ≥4) discriminated between patients with differences in clinical behaviour. This study provides an integrated portrait of the CLL genomic landscape, identifies new recurrent driver mutations of the disease, and suggests clinical interventions that may improve the management of this neoplasia. Genomic approaches in more than 500 patients are used to extend the number of chronic lymphocytic leukaemia (CLL) driver alterations, and also identify novel recurrent mutations in non-coding regions, including an enhancer of PAX5 and the 3′ untranslated region of NOTCH1, which lead to aberrant splicing events, increased NOTCH1 protein stability and activity, and an adverse clinical outcome. This paper from the International Cancer Genomic Consortium reports the results of a number of genomic approaches used to characterize chronic lymphocytic leukaemia and its precursor in more than 500 patients. As well as extending the number of chronic lymphocytic leukaemia driver alterations found in the coding portion of the genome, the study identies novel recurrent mutations in non-coding regions, including the 3′ UTR of NOTCH1, which cause aberrant splicing events, an increase in NOTCH1 activity and more aggressive disease, as well as mutations in an enhancer which result in reduced expression of the B-cell-specific transcription factor PAX5.
      datePublished:2015-07-22T00:00:00Z
      dateModified:2015-10-22T00:00:00Z
      pageStart:519
      pageEnd:524
      sameAs:https://doi.org/10.1038/nature14666
      keywords:
         Cancer
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
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      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:526
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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         type:Organization
      author:
            name:Xose S. Puente
            affiliation:
                  name:Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo
                  address:
                     name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Silvia Beà
            affiliation:
                  name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
                  address:
                     name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rafael Valdés-Mas
            affiliation:
                  name:Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo
                  address:
                     name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Neus Villamor
            affiliation:
                  name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
                  address:
                     name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jesús Gutiérrez-Abril
            affiliation:
                  name:Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo
                  address:
                     name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:José I. Martín-Subero
            affiliation:
                  name:Departament d’Anatomía Patològica, Microbiología i Farmacología, Universitat de Barcelona
                  address:
                     name:Departament d’Anatomía Patològica, Microbiología i Farmacología, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marta Munar
            affiliation:
                  name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
                  address:
                     name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlota Rubio-Pérez
            affiliation:
                  name:Research Unit on Biomedical Informatics, Universitat Pompeu Fabra
                  address:
                     name:Department of Experimental and Health Sciences, Research Unit on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pedro Jares
            affiliation:
                  name:Unidad de Genómica, IDIBAPS
                  address:
                     name:Unidad de Genómica, IDIBAPS, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marta Aymerich
            affiliation:
                  name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
                  address:
                     name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tycho Baumann
            affiliation:
                  name:Servicio de Hematología, Hospital Clínic, IDIBAPS
                  address:
                     name:Servicio de Hematología, Hospital Clínic, IDIBAPS, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Renée Beekman
            affiliation:
                  name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
                  address:
                     name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Laura Belver
            affiliation:
                  name:Institute for Cancer Genetics, Columbia University
                  address:
                     name:Institute for Cancer Genetics, Columbia University, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anna Carrio
            affiliation:
                  name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
                  address:
                     name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Giancarlo Castellano
            affiliation:
                  name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
                  address:
                     name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Guillem Clot
            affiliation:
                  name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
                  address:
                     name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Enrique Colado
            affiliation:
                  name:Servicio de Hematología, Hospital Universitario Central de Asturias
                  address:
                     name:Servicio de Hematología, Hospital Universitario Central de Asturias, Oviedo, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dolors Colomer
            affiliation:
                  name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
                  address:
                     name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dolors Costa
            affiliation:
                  name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
                  address:
                     name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Julio Delgado
            affiliation:
                  name:Servicio de Hematología, Hospital Clínic, IDIBAPS
                  address:
                     name:Servicio de Hematología, Hospital Clínic, IDIBAPS, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anna Enjuanes
            affiliation:
                  name:Unidad de Genómica, IDIBAPS
                  address:
                     name:Unidad de Genómica, IDIBAPS, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xavier Estivill
            affiliation:
                  name:Center for Genomic Regulation (CRG), Pompeu Fabra University (UPF), Hospital del Mar Research Institute (IMIM)
                  address:
                     name:Center for Genomic Regulation (CRG), Pompeu Fabra University (UPF), Hospital del Mar Research Institute (IMIM), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Adolfo A. Ferrando
            affiliation:
                  name:Institute for Cancer Genetics, Columbia University
                  address:
                     name:Institute for Cancer Genetics, Columbia University, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Josep L. Gelpí
            affiliation:
                  name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
                  address:
                     name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Blanca González
            affiliation:
                  name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
                  address:
                     name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Santiago González
            affiliation:
                  name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
                  address:
                     name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marcos González
            affiliation:
                  name:Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC
                  address:
                     name:Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC, Salamanca, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marta Gut
            affiliation:
                  name:Centro Nacional de Análisis Genómico, Parc Científic de Barcelona
                  address:
                     name:Centro Nacional de Análisis Genómico, Parc Científic de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jesús M. Hernández-Rivas
            affiliation:
                  name:Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC
                  address:
                     name:Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC, Salamanca, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mónica López-Guerra
            affiliation:
                  name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
                  address:
                     name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David Martín-García
            affiliation:
                  name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
                  address:
                     name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alba Navarro
            affiliation:
                  name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
                  address:
                     name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pilar Nicolás
            affiliation:
                  name:Cátedra Inter-Universitaria de Derecho y Genoma Humano, Universidad de Deusto, Universidad del País Vasco
                  address:
                     name:Cátedra Inter-Universitaria de Derecho y Genoma Humano, Universidad de Deusto, Universidad del País Vasco, Bilbao, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Modesto Orozco
            affiliation:
                  name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
                  address:
                     name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ángel R. Payer
            affiliation:
                  name:Servicio de Hematología, Hospital Universitario Central de Asturias
                  address:
                     name:Servicio de Hematología, Hospital Universitario Central de Asturias, Oviedo, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Magda Pinyol
            affiliation:
                  name:Unidad de Genómica, IDIBAPS
                  address:
                     name:Unidad de Genómica, IDIBAPS, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David G. Pisano
            affiliation:
                  name:Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Spanish National Bioinformatics Institute
                  address:
                     name:Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Spanish National Bioinformatics Institute, Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Diana A. Puente
            affiliation:
                  name:Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo
                  address:
                     name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ana C. Queirós
            affiliation:
                  name:Departament d’Anatomía Patològica, Microbiología i Farmacología, Universitat de Barcelona
                  address:
                     name:Departament d’Anatomía Patològica, Microbiología i Farmacología, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Víctor Quesada
            affiliation:
                  name:Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo
                  address:
                     name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlos M. Romeo-Casabona
            affiliation:
                  name:Cátedra Inter-Universitaria de Derecho y Genoma Humano, Universidad de Deusto, Universidad del País Vasco
                  address:
                     name:Cátedra Inter-Universitaria de Derecho y Genoma Humano, Universidad de Deusto, Universidad del País Vasco, Bilbao, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cristina Royo
            affiliation:
                  name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
                  address:
                     name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Romina Royo
            affiliation:
                  name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
                  address:
                     name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:María Rozman
            affiliation:
                  name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
                  address:
                     name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nuria Russiñol
            affiliation:
                  name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
                  address:
                     name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Itziar Salaverría
            affiliation:
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      affiliation:
            name:Servicio de Hematología, Hospital Universitario Central de Asturias
            address:
               name:Servicio de Hematología, Hospital Universitario Central de Asturias, Oviedo, Spain
               type:PostalAddress
            type:Organization
      name:Dolors Colomer
      affiliation:
            name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
            address:
               name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Dolors Costa
      affiliation:
            name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
            address:
               name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Julio Delgado
      affiliation:
            name:Servicio de Hematología, Hospital Clínic, IDIBAPS
            address:
               name:Servicio de Hematología, Hospital Clínic, IDIBAPS, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Anna Enjuanes
      affiliation:
            name:Unidad de Genómica, IDIBAPS
            address:
               name:Unidad de Genómica, IDIBAPS, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Xavier Estivill
      affiliation:
            name:Center for Genomic Regulation (CRG), Pompeu Fabra University (UPF), Hospital del Mar Research Institute (IMIM)
            address:
               name:Center for Genomic Regulation (CRG), Pompeu Fabra University (UPF), Hospital del Mar Research Institute (IMIM), Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Adolfo A. Ferrando
      affiliation:
            name:Institute for Cancer Genetics, Columbia University
            address:
               name:Institute for Cancer Genetics, Columbia University, New York, USA
               type:PostalAddress
            type:Organization
      name:Josep L. Gelpí
      affiliation:
            name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
            address:
               name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Blanca González
      affiliation:
            name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
            address:
               name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Santiago González
      affiliation:
            name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
            address:
               name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Marcos González
      affiliation:
            name:Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC
            address:
               name:Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC, Salamanca, Spain
               type:PostalAddress
            type:Organization
      name:Marta Gut
      affiliation:
            name:Centro Nacional de Análisis Genómico, Parc Científic de Barcelona
            address:
               name:Centro Nacional de Análisis Genómico, Parc Científic de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Jesús M. Hernández-Rivas
      affiliation:
            name:Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC
            address:
               name:Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC, Salamanca, Spain
               type:PostalAddress
            type:Organization
      name:Mónica López-Guerra
      affiliation:
            name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
            address:
               name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:David Martín-García
      affiliation:
            name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
            address:
               name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Alba Navarro
      affiliation:
            name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
            address:
               name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Pilar Nicolás
      affiliation:
            name:Cátedra Inter-Universitaria de Derecho y Genoma Humano, Universidad de Deusto, Universidad del País Vasco
            address:
               name:Cátedra Inter-Universitaria de Derecho y Genoma Humano, Universidad de Deusto, Universidad del País Vasco, Bilbao, Spain
               type:PostalAddress
            type:Organization
      name:Modesto Orozco
      affiliation:
            name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
            address:
               name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Ángel R. Payer
      affiliation:
            name:Servicio de Hematología, Hospital Universitario Central de Asturias
            address:
               name:Servicio de Hematología, Hospital Universitario Central de Asturias, Oviedo, Spain
               type:PostalAddress
            type:Organization
      name:Magda Pinyol
      affiliation:
            name:Unidad de Genómica, IDIBAPS
            address:
               name:Unidad de Genómica, IDIBAPS, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:David G. Pisano
      affiliation:
            name:Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Spanish National Bioinformatics Institute
            address:
               name:Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Spanish National Bioinformatics Institute, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Diana A. Puente
      affiliation:
            name:Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo
            address:
               name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
               type:PostalAddress
            type:Organization
      name:Ana C. Queirós
      affiliation:
            name:Departament d’Anatomía Patològica, Microbiología i Farmacología, Universitat de Barcelona
            address:
               name:Departament d’Anatomía Patològica, Microbiología i Farmacología, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Víctor Quesada
      affiliation:
            name:Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo
            address:
               name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
               type:PostalAddress
            type:Organization
      name:Carlos M. Romeo-Casabona
      affiliation:
            name:Cátedra Inter-Universitaria de Derecho y Genoma Humano, Universidad de Deusto, Universidad del País Vasco
            address:
               name:Cátedra Inter-Universitaria de Derecho y Genoma Humano, Universidad de Deusto, Universidad del País Vasco, Bilbao, Spain
               type:PostalAddress
            type:Organization
      name:Cristina Royo
      affiliation:
            name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
            address:
               name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Romina Royo
      affiliation:
            name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
            address:
               name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:María Rozman
      affiliation:
            name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
            address:
               name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Nuria Russiñol
      affiliation:
            name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
            address:
               name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Itziar Salaverría
      affiliation:
            name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
            address:
               name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Kostas Stamatopoulos
      affiliation:
            name:Institute of Applied Biosciences, Center for Research and Technology Hellas
            address:
               name:Institute of Applied Biosciences, Center for Research and Technology Hellas, Thermi, Greece
               type:PostalAddress
            type:Organization
      name:Hendrik G. Stunnenberg
      affiliation:
            name:Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen
            address:
               name:Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
               type:PostalAddress
            type:Organization
      name:David Tamborero
      affiliation:
            name:Research Unit on Biomedical Informatics, Universitat Pompeu Fabra
            address:
               name:Department of Experimental and Health Sciences, Research Unit on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:María J. Terol
      affiliation:
            name:Servicio de Hematología, Hospital Clínico de Valencia
            address:
               name:Servicio de Hematología, Hospital Clínico de Valencia, Valencia, Spain
               type:PostalAddress
            type:Organization
      name:Alfonso Valencia
      affiliation:
            name:Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Spanish National Bioinformatics Institute
            address:
               name:Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Spanish National Bioinformatics Institute, Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Nuria López-Bigas
      affiliation:
            name:Research Unit on Biomedical Informatics, Universitat Pompeu Fabra
            address:
               name:Department of Experimental and Health Sciences, Research Unit on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:David Torrents
      affiliation:
            name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona
            address:
               name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Ivo Gut
      affiliation:
            name:Centro Nacional de Análisis Genómico, Parc Científic de Barcelona
            address:
               name:Centro Nacional de Análisis Genómico, Parc Científic de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Armando López-Guillermo
      affiliation:
            name:Servicio de Hematología, Hospital Clínic, IDIBAPS
            address:
               name:Servicio de Hematología, Hospital Clínic, IDIBAPS, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Carlos López-Otín
      affiliation:
            name:Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo
            address:
               name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Elías Campo
      affiliation:
            name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona
            address:
               name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
      name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
      name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
      name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
      name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
      name:Departament d’Anatomía Patològica, Microbiología i Farmacología, Universitat de Barcelona, Barcelona, Spain
      name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
      name:Department of Experimental and Health Sciences, Research Unit on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
      name:Unidad de Genómica, IDIBAPS, Barcelona, Spain
      name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
      name:Servicio de Hematología, Hospital Clínic, IDIBAPS, Barcelona, Spain
      name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
      name:Institute for Cancer Genetics, Columbia University, New York, USA
      name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
      name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
      name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
      name:Servicio de Hematología, Hospital Universitario Central de Asturias, Oviedo, Spain
      name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
      name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
      name:Servicio de Hematología, Hospital Clínic, IDIBAPS, Barcelona, Spain
      name:Unidad de Genómica, IDIBAPS, Barcelona, Spain
      name:Center for Genomic Regulation (CRG), Pompeu Fabra University (UPF), Hospital del Mar Research Institute (IMIM), Barcelona, Spain
      name:Institute for Cancer Genetics, Columbia University, New York, USA
      name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
      name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
      name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
      name:Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC, Salamanca, Spain
      name:Centro Nacional de Análisis Genómico, Parc Científic de Barcelona, Barcelona, Spain
      name:Servicio de Hematología, IBSAL-Hospital Universitario de Salamanca, Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC, Salamanca, Spain
      name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
      name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
      name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
      name:Cátedra Inter-Universitaria de Derecho y Genoma Humano, Universidad de Deusto, Universidad del País Vasco, Bilbao, Spain
      name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
      name:Servicio de Hematología, Hospital Universitario Central de Asturias, Oviedo, Spain
      name:Unidad de Genómica, IDIBAPS, Barcelona, Spain
      name:Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Spanish National Bioinformatics Institute, Madrid, Spain
      name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
      name:Departament d’Anatomía Patològica, Microbiología i Farmacología, Universitat de Barcelona, Barcelona, Spain
      name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
      name:Cátedra Inter-Universitaria de Derecho y Genoma Humano, Universidad de Deusto, Universidad del País Vasco, Bilbao, Spain
      name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
      name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
      name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
      name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
      name:Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
      name:Institute of Applied Biosciences, Center for Research and Technology Hellas, Thermi, Greece
      name:Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
      name:Department of Experimental and Health Sciences, Research Unit on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
      name:Servicio de Hematología, Hospital Clínico de Valencia, Valencia, Spain
      name:Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Spanish National Bioinformatics Institute, Madrid, Spain
      name:Department of Experimental and Health Sciences, Research Unit on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
      name:Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain
      name:Centro Nacional de Análisis Genómico, Parc Científic de Barcelona, Barcelona, Spain
      name:Servicio de Hematología, Hospital Clínic, IDIBAPS, Barcelona, Spain
      name:Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
      name:Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
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