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We began analyzing https://www.nature.com/articles/bjc198546, but it redirected us to https://www.nature.com/articles/bjc198546. The analysis below is for the second page.

Title[redir]:
Characteristics of human tumour xenografts transplanted under the renal capsule of immunocompetent mice | British Journal of Cancer
Description:
Human tumour lines established in athymic nude mice were grafted under the renal capsule of immunocompetent mice. Grafts from 27 human tumour lines comprising 9 malignant melanomas, 10 sarcomas, 2 colon carcinomas, 4 lung carcinomas and 2 mammary carcinomas, grew well under the renal capsule of the immunocompetent mice and retained morphological and functional characteristics of the parent tumours, as judged by light and electron microscopy and immunohistochemical examinations. Numerous mitoses were detected. Granulation tissue and necrosis were not predominant features. After Day 4, the grafts became infiltrated from the periphery by mouse inflammatory cells. The infiltration could be prevented by pretreatment of the animals with cyclophosphamide. Anti-human antibodies were detected after Day 3. Single cell suspensions from the subrenal grafts were able to form colonies in soft agar. and upon reimplantation in nude mice, subcutaneous tumours were formed showing that the grafted tumour tissue had also retained its malignant character. Altogether the results support the view that human tumour xenografts grow well under the renal capsule of immunocompetent mice and that the grafts retain important characteristics of the original tumour.

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Keywords {πŸ”}

nature, article, access, cancer, content, journal, tumour, mice, cookies, renal, privacy, human, capsule, immunocompetent, open, data, british, characteristics, grafts, cell, research, advertising, subscribe, original, xenografts, carcinomas, institution, buy, permissions, optional, analysis, media, personal, parties, policy, information, view, journals, log, march, transplanted, aamdal, fodstad, nesland, cite, lines, nude, grafted, malignant, lung,

Topics {βœ’οΈ}

nature portfolio cell-surface-antigen-density-dependent manner permissions reprints cancer research privacy policy nature advertising social media single cell suspensions kras/lkb1 mutant nsclc personal data springerlink instant access data protection permissions mouse inflammatory cells anti-human antibodies privacy original tumour explore content subscription content grafted tumour tissue european economic area institutional subscriptions read chemo-immuno combination accepting optional cookies journals search log spatial transcriptomics analysis manage preferences article purchase athymic nude mice content access article cite article aamdal 4 lung carcinomas malignant character results support issue learn optional cookies article journal publish οΏ½rmann journal choices essential cookies cookies skip renal capsule institution subscribe institution buy cancer models nude mice

Schema {πŸ—ΊοΈ}

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         description:Human tumour lines established in athymic nude mice were grafted under the renal capsule of immunocompetent mice. Grafts from 27 human tumour lines comprising 9 malignant melanomas, 10 sarcomas, 2 colon carcinomas, 4 lung carcinomas and 2 mammary carcinomas, grew well under the renal capsule of the immunocompetent mice and retained morphological and functional characteristics of the parent tumours, as judged by light and electron microscopy and immunohistochemical examinations. Numerous mitoses were detected. Granulation tissue and necrosis were not predominant features. After Day 4, the grafts became infiltrated from the periphery by mouse inflammatory cells. The infiltration could be prevented by pretreatment of the animals with cyclophosphamide. Anti-human antibodies were detected after Day 3. Single cell suspensions from the subrenal grafts were able to form colonies in soft agar. and upon reimplantation in nude mice, subcutaneous tumours were formed showing that the grafted tumour tissue had also retained its malignant character. Altogether the results support the view that human tumour xenografts grow well under the renal capsule of immunocompetent mice and that the grafts retain important characteristics of the original tumour.
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      headline:Characteristics of human tumour xenografts transplanted under the renal capsule of immunocompetent mice
      description:Human tumour lines established in athymic nude mice were grafted under the renal capsule of immunocompetent mice. Grafts from 27 human tumour lines comprising 9 malignant melanomas, 10 sarcomas, 2 colon carcinomas, 4 lung carcinomas and 2 mammary carcinomas, grew well under the renal capsule of the immunocompetent mice and retained morphological and functional characteristics of the parent tumours, as judged by light and electron microscopy and immunohistochemical examinations. Numerous mitoses were detected. Granulation tissue and necrosis were not predominant features. After Day 4, the grafts became infiltrated from the periphery by mouse inflammatory cells. The infiltration could be prevented by pretreatment of the animals with cyclophosphamide. Anti-human antibodies were detected after Day 3. Single cell suspensions from the subrenal grafts were able to form colonies in soft agar. and upon reimplantation in nude mice, subcutaneous tumours were formed showing that the grafted tumour tissue had also retained its malignant character. Altogether the results support the view that human tumour xenografts grow well under the renal capsule of immunocompetent mice and that the grafts retain important characteristics of the original tumour.
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