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We are analyzing https://www.nature.com/articles/bjc198546.

Title:
Characteristics of human tumour xenografts transplanted under the renal capsule of immunocompetent mice | British Journal of Cancer
Description:
Human tumour lines established in athymic nude mice were grafted under the renal capsule of immunocompetent mice. Grafts from 27 human tumour lines comprising 9 malignant melanomas, 10 sarcomas, 2 colon carcinomas, 4 lung carcinomas and 2 mammary carcinomas, grew well under the renal capsule of the immunocompetent mice and retained morphological and functional characteristics of the parent tumours, as judged by light and electron microscopy and immunohistochemical examinations. Numerous mitoses were detected. Granulation tissue and necrosis were not predominant features. After Day 4, the grafts became infiltrated from the periphery by mouse inflammatory cells. The infiltration could be prevented by pretreatment of the animals with cyclophosphamide. Anti-human antibodies were detected after Day 3. Single cell suspensions from the subrenal grafts were able to form colonies in soft agar. and upon reimplantation in nude mice, subcutaneous tumours were formed showing that the grafted tumour tissue had also retained its malignant character. Altogether the results support the view that human tumour xenografts grow well under the renal capsule of immunocompetent mice and that the grafts retain important characteristics of the original tumour.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {πŸ“š}

  • Telecommunications
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Content Management System {πŸ“}

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Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

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πŸŒ† Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 41,362,249 visitors per month in the current month.

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Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

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$521,200 per month
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Keywords {πŸ”}

nature, article, access, cancer, content, journal, tumour, mice, cookies, renal, privacy, human, capsule, immunocompetent, open, data, british, characteristics, grafts, cell, research, advertising, subscribe, original, xenografts, carcinomas, institution, buy, permissions, optional, analysis, media, personal, parties, policy, information, view, journals, log, march, transplanted, aamdal, fodstad, nesland, cite, lines, nude, grafted, malignant, lung,

Topics {βœ’οΈ}

nature portfolio cell-surface-antigen-density-dependent manner permissions reprints cancer research privacy policy nature advertising social media single cell suspensions kras/lkb1 mutant nsclc personal data springerlink instant access data protection permissions mouse inflammatory cells anti-human antibodies privacy original tumour explore content subscription content grafted tumour tissue european economic area institutional subscriptions read chemo-immuno combination accepting optional cookies journals search log spatial transcriptomics analysis manage preferences article purchase athymic nude mice content access article cite article aamdal 4 lung carcinomas malignant character results support issue learn optional cookies article journal publish οΏ½rmann journal choices essential cookies cookies skip renal capsule institution subscribe institution buy cancer models nude mice

Schema {πŸ—ΊοΈ}

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