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We began analyzing https://link.springer.com/article/10.1007/s13277-013-0774-3, but it redirected us to https://link.springer.com/article/10.1007/s13277-013-0774-3. The analysis below is for the second page.

Title[redir]:
Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer | Tumor Biology
Description:
HuR is an ubiquitously expressed RNA-binding protein that stabilizes messenger RNA and regulates translation. This protein has been shown to play an important role in carcinogenesis and cancer progression. P-glycoprotein (P-gp) is the product of the multidrug resistance 1 gene, and the overexpression of P-gp induces multidrug resistance and represents a major obstacle in cancer chemotherapy. The purpose of this study was to determine the expression of HuR and P-gp in human breast cancer tissues and analyze the relationship between HuR or P-gp expression and the clinical–pathological variables and patient outcomes. Immunohistochemistry was used to determine HuR and P-gp expression in 82 human breast cancer tissues and 20 matched adjacent noncancerous tissues. Additionally, 16 benign breast tumor samples were used as controls. The overexpression of cytoplasmic HuR was found in breast cancer but not in the matched adjacent noncancerous tissues or benign breast tumors. The expression levels of cytoplasmic HuR were significantly associated with increased age, high nuclear grade, and the positive expression of the ER, PR, and HER-2/neu. HuR was also associated with the expression of P-gp protein. Furthermore, univariate analysis indicates that patients with high expression levels of cytoplasmic HuR or P-gp had significantly reduced survival compared to patients with low expression levels. A multivariate analysis showed that age at diagnosis, nuclear grade, and cytoplasmic HuR positivity were independent indicators for disease-free survival and overall survival in patients with breast cancer. In conclusion, cytoplasmic HuR expression detected by immunohistochemical staining is a negative prognostic indicator for survival in patients with breast cancer.

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šŸ™ļø Massive Traffic: 50M - 100M visitors per month


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Keywords {šŸ”}

cancer, article, google, scholar, hur, pubmed, breast, cas, expression, protein, wang, cytoplasmic, human, pgp, resistance, prognostic, res, rnabinding, cells, rna, growth, biol, cell, tumor, guo, patients, mol, access, carcinoma, cyclin, privacy, cookies, content, correlates, poor, zhang, survival, prognosis, binding, jinan, analysis, information, publish, research, search, outcome, zhu, role, multidrug, gene,

Topics {āœ’ļø}

au-rich mrna-binding protein month download article/chapter rna-binding protein hur camp-regulated phosphoprotein 32 kda elevated hu-antigen receptor early-stage breast cancer node-negative breast cancer full article pdf nature science foundation stabilizes messenger rna privacy choices/manage cookies lymph node metastasis uv-induced apoptosis p-gp protein related subjects human breast carcinoma rnabinding protein network benign breast tumors early breast cancer serous ovarian carcinoma breast cancer cells doxycycline induces expression hereditary breast cancer oral cancer cells prostate cancer cells human breast cancer microrna mir-331-3p p-gp expression cytoplasmic hur expression wang equally contributed european economic area clinical–pathological variables adjuvant systemic therapy lymphatic microvessel density natl cancer inst endocrinol relat cancer van der valk van kalken ck high level predicts costantino cl breast cancer patients clin breast cancer hum mol genet conditions privacy policy cyclin e1 deregulation reducing hur levels cancer res treat article zhu antimicrob agents chemother med sci monit

Questions {ā“}

  • Proliferative markers as prognostic and predictive tools in early breast cancer: where are we now?

Schema {šŸ—ŗļø}

WebPage:
      mainEntity:
         headline:Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer
         description:HuR is an ubiquitously expressed RNA-binding protein that stabilizes messenger RNA and regulates translation. This protein has been shown to play an important role in carcinogenesis and cancer progression. P-glycoprotein (P-gp) is the product of the multidrug resistance 1 gene, and the overexpression of P-gp induces multidrug resistance and represents a major obstacle in cancer chemotherapy. The purpose of this study was to determine the expression of HuR and P-gp in human breast cancer tissues and analyze the relationship between HuR or P-gp expression and the clinical–pathological variables and patient outcomes. Immunohistochemistry was used to determine HuR and P-gp expression in 82 human breast cancer tissues and 20 matched adjacent noncancerous tissues. Additionally, 16 benign breast tumor samples were used as controls. The overexpression of cytoplasmic HuR was found in breast cancer but not in the matched adjacent noncancerous tissues or benign breast tumors. The expression levels of cytoplasmic HuR were significantly associated with increased age, high nuclear grade, and the positive expression of the ER, PR, and HER-2/neu. HuR was also associated with the expression of P-gp protein. Furthermore, univariate analysis indicates that patients with high expression levels of cytoplasmic HuR or P-gp had significantly reduced survival compared to patients with low expression levels. A multivariate analysis showed that age at diagnosis, nuclear grade, and cytoplasmic HuR positivity were independent indicators for disease-free survival and overall survival in patients with breast cancer. In conclusion, cytoplasmic HuR expression detected by immunohistochemical staining is a negative prognostic indicator for survival in patients with breast cancer.
         datePublished:2013-04-19T00:00:00Z
         dateModified:2013-04-19T00:00:00Z
         pageStart:2299
         pageEnd:2308
         sameAs:https://doi.org/10.1007/s13277-013-0774-3
         keywords:
            HuR
            P-gp
            Breast cancer
            Prognosis
            Cancer Research
         image:
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               name:Zhongpeng Zhu
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                     name:General Hospital, Jinan Command of People’s Liberation Army
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                        name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
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               name:Baocheng Wang
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                     name:General Hospital, Jinan Command of People’s Liberation Army
                     address:
                        name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                        type:PostalAddress
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               name:Jingwang Bi
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                        type:PostalAddress
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                     name:General Hospital, Jinan Command of the People’s Liberation Army
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                        type:PostalAddress
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                        type:PostalAddress
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                        name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                        type:PostalAddress
                     type:Organization
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                     name:General Hospital, Jinan Command of People’s Liberation Army
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                        type:PostalAddress
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               name:Jun Wang
               affiliation:
                     name:General Hospital, Jinan Command of People’s Liberation Army
                     address:
                        name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
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ScholarlyArticle:
      headline:Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer
      description:HuR is an ubiquitously expressed RNA-binding protein that stabilizes messenger RNA and regulates translation. This protein has been shown to play an important role in carcinogenesis and cancer progression. P-glycoprotein (P-gp) is the product of the multidrug resistance 1 gene, and the overexpression of P-gp induces multidrug resistance and represents a major obstacle in cancer chemotherapy. The purpose of this study was to determine the expression of HuR and P-gp in human breast cancer tissues and analyze the relationship between HuR or P-gp expression and the clinical–pathological variables and patient outcomes. Immunohistochemistry was used to determine HuR and P-gp expression in 82 human breast cancer tissues and 20 matched adjacent noncancerous tissues. Additionally, 16 benign breast tumor samples were used as controls. The overexpression of cytoplasmic HuR was found in breast cancer but not in the matched adjacent noncancerous tissues or benign breast tumors. The expression levels of cytoplasmic HuR were significantly associated with increased age, high nuclear grade, and the positive expression of the ER, PR, and HER-2/neu. HuR was also associated with the expression of P-gp protein. Furthermore, univariate analysis indicates that patients with high expression levels of cytoplasmic HuR or P-gp had significantly reduced survival compared to patients with low expression levels. A multivariate analysis showed that age at diagnosis, nuclear grade, and cytoplasmic HuR positivity were independent indicators for disease-free survival and overall survival in patients with breast cancer. In conclusion, cytoplasmic HuR expression detected by immunohistochemical staining is a negative prognostic indicator for survival in patients with breast cancer.
      datePublished:2013-04-19T00:00:00Z
      dateModified:2013-04-19T00:00:00Z
      pageStart:2299
      pageEnd:2308
      sameAs:https://doi.org/10.1007/s13277-013-0774-3
      keywords:
         HuR
         P-gp
         Breast cancer
         Prognosis
         Cancer Research
      image:
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      isPartOf:
         name:Tumor Biology
         issn:
            1423-0380
            1010-4283
         volumeNumber:34
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Zhongpeng Zhu
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Baocheng Wang
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jingwang Bi
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cong Zhang
            affiliation:
                  name:General Hospital, Jinan Command of the People’s Liberation Army
                  address:
                     name:Department of Radiotherapy, General Hospital, Jinan Command of the People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yan Guo
            affiliation:
                  name:Military Command of Shandong Province
                  address:
                     name:Department of Outpatient, Military Command of Shandong Province, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Huili Chu
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiuju Liang
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chen Zhong
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jun Wang
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
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      name:General Hospital, Jinan Command of People’s Liberation Army
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      name:General Hospital, Jinan Command of People’s Liberation Army
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         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
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      name:General Hospital, Jinan Command of the People’s Liberation Army
      address:
         name:Department of Radiotherapy, General Hospital, Jinan Command of the People’s Liberation Army, Jinan, China
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      name:Military Command of Shandong Province
      address:
         name:Department of Outpatient, Military Command of Shandong Province, Jinan, China
         type:PostalAddress
      name:General Hospital, Jinan Command of People’s Liberation Army
      address:
         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
         type:PostalAddress
      name:General Hospital, Jinan Command of People’s Liberation Army
      address:
         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
         type:PostalAddress
      name:General Hospital, Jinan Command of People’s Liberation Army
      address:
         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
         type:PostalAddress
      name:General Hospital, Jinan Command of People’s Liberation Army
      address:
         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
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      name:Zhongpeng Zhu
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      name:Baocheng Wang
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jingwang Bi
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      name:Cong Zhang
      affiliation:
            name:General Hospital, Jinan Command of the People’s Liberation Army
            address:
               name:Department of Radiotherapy, General Hospital, Jinan Command of the People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      name:Yan Guo
      affiliation:
            name:Military Command of Shandong Province
            address:
               name:Department of Outpatient, Military Command of Shandong Province, Jinan, China
               type:PostalAddress
            type:Organization
      name:Huili Chu
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      name:Xiuju Liang
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      name:Chen Zhong
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      name:Jun Wang
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Radiotherapy, General Hospital, Jinan Command of the People’s Liberation Army, Jinan, China
      name:Department of Outpatient, Military Command of Shandong Province, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
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