
DOI . ORG {
}
Title[redir]:
Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer | Tumor Biology
Description:
HuR is an ubiquitously expressed RNA-binding protein that stabilizes messenger RNA and regulates translation. This protein has been shown to play an important role in carcinogenesis and cancer progression. P-glycoprotein (P-gp) is the product of the multidrug resistance 1 gene, and the overexpression of P-gp induces multidrug resistance and represents a major obstacle in cancer chemotherapy. The purpose of this study was to determine the expression of HuR and P-gp in human breast cancer tissues and analyze the relationship between HuR or P-gp expression and the clinicalāpathological variables and patient outcomes. Immunohistochemistry was used to determine HuR and P-gp expression in 82 human breast cancer tissues and 20 matched adjacent noncancerous tissues. Additionally, 16 benign breast tumor samples were used as controls. The overexpression of cytoplasmic HuR was found in breast cancer but not in the matched adjacent noncancerous tissues or benign breast tumors. The expression levels of cytoplasmic HuR were significantly associated with increased age, high nuclear grade, and the positive expression of the ER, PR, and HER-2/neu. HuR was also associated with the expression of P-gp protein. Furthermore, univariate analysis indicates that patients with high expression levels of cytoplasmic HuR or P-gp had significantly reduced survival compared to patients with low expression levels. A multivariate analysis showed that age at diagnosis, nuclear grade, and cytoplasmic HuR positivity were independent indicators for disease-free survival and overall survival in patients with breast cancer. In conclusion, cytoplasmic HuR expression detected by immunohistochemical staining is a negative prognostic indicator for survival in patients with breast cancer.
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Keywords {š}
cancer, article, google, scholar, hur, pubmed, breast, cas, expression, protein, wang, cytoplasmic, human, pgp, resistance, prognostic, res, rnabinding, cells, rna, growth, biol, cell, tumor, guo, patients, mol, access, carcinoma, cyclin, privacy, cookies, content, correlates, poor, zhang, survival, prognosis, binding, jinan, analysis, information, publish, research, search, outcome, zhu, role, multidrug, gene,
Topics {āļø}
au-rich mrna-binding protein month download article/chapter rna-binding protein hur camp-regulated phosphoprotein 32ākda elevated hu-antigen receptor early-stage breast cancer node-negative breast cancer full article pdf nature science foundation stabilizes messenger rna privacy choices/manage cookies lymph node metastasis uv-induced apoptosis p-gp protein related subjects human breast carcinoma rnabinding protein network benign breast tumors early breast cancer serous ovarian carcinoma breast cancer cells doxycycline induces expression hereditary breast cancer oral cancer cells prostate cancer cells human breast cancer microrna mir-331-3p p-gp expression cytoplasmic hur expression wang equally contributed european economic area clinicalāpathological variables adjuvant systemic therapy lymphatic microvessel density natl cancer inst endocrinol relat cancer van der valk van kalken ck high level predicts costantino cl breast cancer patients clin breast cancer hum mol genet conditions privacy policy cyclin e1 deregulation reducing hur levels cancer res treat article zhu antimicrob agents chemother med sci monit
Questions {ā}
- Proliferative markers as prognostic and predictive tools in early breast cancer: where are we now?
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headline:Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer
description:HuR is an ubiquitously expressed RNA-binding protein that stabilizes messenger RNA and regulates translation. This protein has been shown to play an important role in carcinogenesis and cancer progression. P-glycoprotein (P-gp) is the product of the multidrug resistance 1 gene, and the overexpression of P-gp induces multidrug resistance and represents a major obstacle in cancer chemotherapy. The purpose of this study was to determine the expression of HuR and P-gp in human breast cancer tissues and analyze the relationship between HuR or P-gp expression and the clinicalāpathological variables and patient outcomes. Immunohistochemistry was used to determine HuR and P-gp expression in 82 human breast cancer tissues and 20 matched adjacent noncancerous tissues. Additionally, 16 benign breast tumor samples were used as controls. The overexpression of cytoplasmic HuR was found in breast cancer but not in the matched adjacent noncancerous tissues or benign breast tumors. The expression levels of cytoplasmic HuR were significantly associated with increased age, high nuclear grade, and the positive expression of the ER, PR, and HER-2/neu. HuR was also associated with the expression of P-gp protein. Furthermore, univariate analysis indicates that patients with high expression levels of cytoplasmic HuR or P-gp had significantly reduced survival compared to patients with low expression levels. A multivariate analysis showed that age at diagnosis, nuclear grade, and cytoplasmic HuR positivity were independent indicators for disease-free survival and overall survival in patients with breast cancer. In conclusion, cytoplasmic HuR expression detected by immunohistochemical staining is a negative prognostic indicator for survival in patients with breast cancer.
datePublished:2013-04-19T00:00:00Z
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P-gp
Breast cancer
Prognosis
Cancer Research
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headline:Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer
description:HuR is an ubiquitously expressed RNA-binding protein that stabilizes messenger RNA and regulates translation. This protein has been shown to play an important role in carcinogenesis and cancer progression. P-glycoprotein (P-gp) is the product of the multidrug resistance 1 gene, and the overexpression of P-gp induces multidrug resistance and represents a major obstacle in cancer chemotherapy. The purpose of this study was to determine the expression of HuR and P-gp in human breast cancer tissues and analyze the relationship between HuR or P-gp expression and the clinicalāpathological variables and patient outcomes. Immunohistochemistry was used to determine HuR and P-gp expression in 82 human breast cancer tissues and 20 matched adjacent noncancerous tissues. Additionally, 16 benign breast tumor samples were used as controls. The overexpression of cytoplasmic HuR was found in breast cancer but not in the matched adjacent noncancerous tissues or benign breast tumors. The expression levels of cytoplasmic HuR were significantly associated with increased age, high nuclear grade, and the positive expression of the ER, PR, and HER-2/neu. HuR was also associated with the expression of P-gp protein. Furthermore, univariate analysis indicates that patients with high expression levels of cytoplasmic HuR or P-gp had significantly reduced survival compared to patients with low expression levels. A multivariate analysis showed that age at diagnosis, nuclear grade, and cytoplasmic HuR positivity were independent indicators for disease-free survival and overall survival in patients with breast cancer. In conclusion, cytoplasmic HuR expression detected by immunohistochemical staining is a negative prognostic indicator for survival in patients with breast cancer.
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P-gp
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