We are analyzing https://link.springer.com/article/10.1007/s11033-012-2024-y.

Title:
Lymphatic microvessel density and vascular endothelial growth factor-C and -D as prognostic factors in breast cancer: a systematic review and meta-analysis of the literature | Molecular Biology Reports
Description:
The use of lymphatic microvessel density (LVD) and pro-lymphangiogenic mediators as prognostic factors for survival in breast cancer remains controversial. We searched the electronic databases PubMed and EMBASE without language restrictions for relevant literature to aggregate the survival results. To be eligible, every study had to include the assessment of the LVD or the expression of vascular endothelial growth factor (VEGF)-C or -D in patients with breast cancer and provide a survival comparison, including disease-free survival (DFS) or overall survival (OS), according to the LVD, VEGF-C or VEGF-D status. Across all studies, 56.64 % of patients were considered to have a VEGF-C-positive tumor, and 65.54 % of patients had VEGF-D-positive tumors. High LVD had an unfavorable impact on DFS, with a pooled hazard ratio (HR) of 2.222 (95 % CI 1.579–3.126) and an OS with a HR of 2.493 (95 % CI 1.183–5.25). According to the different lymphatic makers, the subgroup HR in the D2-40 studies was 2.431 (95 % CI 1.622–3.644) for DFS and 4.085 (95 % CI 1.896–8.799) for OS. VEGF-C overexpression, as assessed by immunochemistry, was a prognostic factor for decreased DFS (HR 2.164; 95 % CI 1.256–3.729) and for decreased OS (HR 2.613; 95 % CI 1.637–4.170). VEGF-D overexpression was a significant although weak prognostic factor for DFS only when assessed by immunochemistry, with a HR of 2.108 (95 % CI 1.014–4.384). Our meta-analysis demonstrated that LVD, VEGF-C and VEGF-D could predict poor prognosis in patients with breast cancer. However, standardization of the assessment of LVD and for the expression of lymphangiogenesis factors is needed.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,932 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

cancer, google, scholar, pubmed, article, breast, cas, vascular, endothelial, growth, expression, lymphatic, prognostic, lymphangiogenesis, vegfc, metastasis, factor, res, density, wang, metaanalysis, microvessel, carcinoma, factors, survival, cell, patients, tumor, pathol, factorc, clin, lung, significance, review, literature, guo, prognosis, human, lymph, systematic, oncol, alitalo, node, chen, receptor, yang, van, study, vegfd, tumors,

Topics {✒️}

including disease-free survival month download article/chapter virus-mediated gene transfer rna-binding protein hur small-cell lung carcinoma meta-analysis confirms bcl2 prognosis meta-analysis access vegf-d-positive tumors breast cancer—10 years follow vegf-c-positive tumor full article pdf lymphatic endothelial cells electronic databases pubmed vegf-family gene expression hypoxia-inducible factor hypoxia inducible factor privacy choices/manage cookies lymphatic vascular specificity lymphangiogenic growth factors lymphatic vessel density lymphatic microvessel density lymphangiogenic microvessel density van laere sj peritumoral lymphatic density blood vascular densities blood vessel density human disease van marck ea ductal breast carcinoma lymphatic endothelial regulation invasive breast carcinomas ductal breast cancer weak prognostic factor long-term prognosis lymph-specific receptor long-term follow sentinel lymph nodes pro-lymphangiogenic mediators invasive breast carcinoma lymph node metastasis promotes lymphatic metastasis mouse lung adenocarcinoma blood vessel morphometry human breast carcinoma murine lymphatic system european economic area pooled hazard ratio predict poor prognosis adjuvant systemic therapy dose-dependent response

Questions {❓}

Colozza M, Azambuja E, Cardoso F, Sotiriou C, Larsimont D, Piccart MJ (2005) Proliferative markers as prognostic and predictive tools in early breast cancer: where are we now?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Lymphatic microvessel density and vascular endothelial growth factor-C and -D as prognostic factors in breast cancer: a systematic review and meta-analysis of the literature
         description:The use of lymphatic microvessel density (LVD) and pro-lymphangiogenic mediators as prognostic factors for survival in breast cancer remains controversial. We searched the electronic databases PubMed and EMBASE without language restrictions for relevant literature to aggregate the survival results. To be eligible, every study had to include the assessment of the LVD or the expression of vascular endothelial growth factor (VEGF)-C or -D in patients with breast cancer and provide a survival comparison, including disease-free survival (DFS) or overall survival (OS), according to the LVD, VEGF-C or VEGF-D status. Across all studies, 56.64 % of patients were considered to have a VEGF-C-positive tumor, and 65.54 % of patients had VEGF-D-positive tumors. High LVD had an unfavorable impact on DFS, with a pooled hazard ratio (HR) of 2.222 (95 % CI 1.579–3.126) and an OS with a HR of 2.493 (95 % CI 1.183–5.25). According to the different lymphatic makers, the subgroup HR in the D2-40 studies was 2.431 (95 % CI 1.622–3.644) for DFS and 4.085 (95 % CI 1.896–8.799) for OS. VEGF-C overexpression, as assessed by immunochemistry, was a prognostic factor for decreased DFS (HR 2.164; 95 % CI 1.256–3.729) and for decreased OS (HR 2.613; 95 % CI 1.637–4.170). VEGF-D overexpression was a significant although weak prognostic factor for DFS only when assessed by immunochemistry, with a HR of 2.108 (95 % CI 1.014–4.384). Our meta-analysis demonstrated that LVD, VEGF-C and VEGF-D could predict poor prognosis in patients with breast cancer. However, standardization of the assessment of LVD and for the expression of lymphangiogenesis factors is needed.
         datePublished:2012-10-11T00:00:00Z
         dateModified:2012-10-11T00:00:00Z
         pageStart:11153
         pageEnd:11165
         sameAs:https://doi.org/10.1007/s11033-012-2024-y
         keywords:
            Breast cancer
            Lymphatic microvessel density
            Lymphangiogenesis
            Vascular endothelial growth factor-C
            Vascular endothelial growth factor-D
            Prognosis
            Meta-analysis
            Animal Biochemistry
            Animal Anatomy / Morphology / Histology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2024-y/MediaObjects/11033_2012_2024_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2024-y/MediaObjects/11033_2012_2024_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2024-y/MediaObjects/11033_2012_2024_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2024-y/MediaObjects/11033_2012_2024_Fig4_HTML.gif
         isPartOf:
            name:Molecular Biology Reports
            issn:
               1573-4978
               0301-4851
            volumeNumber:39
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jun Wang
               affiliation:
                     name:General Hospital, Jinan Command of People’s Liberation Army
                     address:
                        name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Yan Guo
               affiliation:
                     name:Military Command of Shandong Province
                     address:
                        name:Department of Outpatient, Military Command of Shandong Province, Jinan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Baocheng Wang
               affiliation:
                     name:General Hospital, Jinan Command of People’s Liberation Army
                     address:
                        name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jingwang Bi
               affiliation:
                     name:General Hospital, Jinan Command of People’s Liberation Army
                     address:
                        name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kainan Li
               affiliation:
                     name:General Hospital, Jinan Command of People’s Liberation Army
                     address:
                        name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiuju Liang
               affiliation:
                     name:General Hospital, Jinan Command of People’s Liberation Army
                     address:
                        name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Huili Chu
               affiliation:
                     name:General Hospital, Jinan Command of People’s Liberation Army
                     address:
                        name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Huihui Jiang
               affiliation:
                     name:General Hospital, Jinan Command of People’s Liberation Army
                     address:
                        name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Lymphatic microvessel density and vascular endothelial growth factor-C and -D as prognostic factors in breast cancer: a systematic review and meta-analysis of the literature
      description:The use of lymphatic microvessel density (LVD) and pro-lymphangiogenic mediators as prognostic factors for survival in breast cancer remains controversial. We searched the electronic databases PubMed and EMBASE without language restrictions for relevant literature to aggregate the survival results. To be eligible, every study had to include the assessment of the LVD or the expression of vascular endothelial growth factor (VEGF)-C or -D in patients with breast cancer and provide a survival comparison, including disease-free survival (DFS) or overall survival (OS), according to the LVD, VEGF-C or VEGF-D status. Across all studies, 56.64 % of patients were considered to have a VEGF-C-positive tumor, and 65.54 % of patients had VEGF-D-positive tumors. High LVD had an unfavorable impact on DFS, with a pooled hazard ratio (HR) of 2.222 (95 % CI 1.579–3.126) and an OS with a HR of 2.493 (95 % CI 1.183–5.25). According to the different lymphatic makers, the subgroup HR in the D2-40 studies was 2.431 (95 % CI 1.622–3.644) for DFS and 4.085 (95 % CI 1.896–8.799) for OS. VEGF-C overexpression, as assessed by immunochemistry, was a prognostic factor for decreased DFS (HR 2.164; 95 % CI 1.256–3.729) and for decreased OS (HR 2.613; 95 % CI 1.637–4.170). VEGF-D overexpression was a significant although weak prognostic factor for DFS only when assessed by immunochemistry, with a HR of 2.108 (95 % CI 1.014–4.384). Our meta-analysis demonstrated that LVD, VEGF-C and VEGF-D could predict poor prognosis in patients with breast cancer. However, standardization of the assessment of LVD and for the expression of lymphangiogenesis factors is needed.
      datePublished:2012-10-11T00:00:00Z
      dateModified:2012-10-11T00:00:00Z
      pageStart:11153
      pageEnd:11165
      sameAs:https://doi.org/10.1007/s11033-012-2024-y
      keywords:
         Breast cancer
         Lymphatic microvessel density
         Lymphangiogenesis
         Vascular endothelial growth factor-C
         Vascular endothelial growth factor-D
         Prognosis
         Meta-analysis
         Animal Biochemistry
         Animal Anatomy / Morphology / Histology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2024-y/MediaObjects/11033_2012_2024_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2024-y/MediaObjects/11033_2012_2024_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2024-y/MediaObjects/11033_2012_2024_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11033-012-2024-y/MediaObjects/11033_2012_2024_Fig4_HTML.gif
      isPartOf:
         name:Molecular Biology Reports
         issn:
            1573-4978
            0301-4851
         volumeNumber:39
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jun Wang
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Yan Guo
            affiliation:
                  name:Military Command of Shandong Province
                  address:
                     name:Department of Outpatient, Military Command of Shandong Province, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Baocheng Wang
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jingwang Bi
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kainan Li
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiuju Liang
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Huili Chu
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Huihui Jiang
            affiliation:
                  name:General Hospital, Jinan Command of People’s Liberation Army
                  address:
                     name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Molecular Biology Reports
      issn:
         1573-4978
         0301-4851
      volumeNumber:39
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:General Hospital, Jinan Command of People’s Liberation Army
      address:
         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
         type:PostalAddress
      name:Military Command of Shandong Province
      address:
         name:Department of Outpatient, Military Command of Shandong Province, Jinan, China
         type:PostalAddress
      name:General Hospital, Jinan Command of People’s Liberation Army
      address:
         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
         type:PostalAddress
      name:General Hospital, Jinan Command of People’s Liberation Army
      address:
         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
         type:PostalAddress
      name:General Hospital, Jinan Command of People’s Liberation Army
      address:
         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
         type:PostalAddress
      name:General Hospital, Jinan Command of People’s Liberation Army
      address:
         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
         type:PostalAddress
      name:General Hospital, Jinan Command of People’s Liberation Army
      address:
         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
         type:PostalAddress
      name:General Hospital, Jinan Command of People’s Liberation Army
      address:
         name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jun Wang
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Yan Guo
      affiliation:
            name:Military Command of Shandong Province
            address:
               name:Department of Outpatient, Military Command of Shandong Province, Jinan, China
               type:PostalAddress
            type:Organization
      name:Baocheng Wang
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      name:Jingwang Bi
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      name:Kainan Li
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      name:Xiuju Liang
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      name:Huili Chu
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
      name:Huihui Jiang
      affiliation:
            name:General Hospital, Jinan Command of People’s Liberation Army
            address:
               name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Outpatient, Military Command of Shandong Province, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
      name:Department of Oncology, General Hospital, Jinan Command of People’s Liberation Army, Jinan, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(290)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.87s.

LINK . SPRINGER . COM {}