
DOI . ORG {
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Title[redir]:
High expression of survivin predicts poor prognosis in esophageal squamous cell carcinoma following radiotherapy | Tumor Biology
Description:
Radiotherapy is one of the main treatments for esophageal squamous cell carcinoma, but there are still no biomarkers to differentiate patients who will benefit from radiation. Although treatment with a combination of radiotherapy with chemotherapy, and/or surgery improves the prognosis of patients, no biomarkers can distinguish between the responses obtained with the combined therapies. Therefore, in this study, we selected patients treated with radiotherapy alone to evaluate survivin as a predictor for radiotherapy. One hundred two biopsy samples collected by endoscopy were immunostained by survivin antibody. Positive staining for survivin was obtained in 60.8% tumor samples. Survivin expression, metastasis, and clinical stage correlated significantly with overall survival. In multivariate analysis, survivin was an independent prognostic factor for predicting overall survival of patients with esophageal cancer. Moreover, in esophageal cancer cell lines, overexpression of survivin reduced the percentage of cell death induced by radiation. Our data indicate that survivin could be a potential predictor to define those patients with esophageal squamous carcinoma who would benefit from radiotherapy.
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Keywords {š}
cancer, article, survivin, google, scholar, pubmed, cas, cell, esophageal, carcinoma, expression, squamous, radiotherapy, patients, prognostic, prognosis, wang, access, research, zhu, china, privacy, cookies, content, zhang, radiation, oesophageal, chinese, gene, nuclear, int, data, publish, search, tumor, quan, liu, zefen, xiao, open, molecular, oncol, altieri, peoples, republic, author, analysis, information, log, journal,
Topics {āļø}
wencheng zhangĀ &Ā zefen xiao therapy-induced cellular senescence squamous cell carcinoma month download article/chapter esophageal squamous carcinoma small-cell lung cancer pathway-directed drug discovery tumor-specific gene expression zefen xiao related subjects anti-apoptosis gene full article pdf cell death induced unresectable stage iii small-molecule suppressor oesophageal carcinoma renal cell cancer altieri dc privacy choices/manage cookies mol cell biochem ec9706 cell line high survivin expression esophageal cancer cells radiation therapy radiation oncology article zhu check access state key laboratory instant access nuclear survivin expression professor mingrong wang global cancer statistics cancer chemother pharmacol independent prognostic factor good prognostic biomarker splice variant expression intratumoral survivin expression advanced solid tumors nat rev cancer european economic area candidate genes involved response-predictive genes dna damage repair accurate prognostic marker conditions privacy policy biopsy samples collected continuous fractionated irradiation cancer therapeutic target article log sichuan cancer hospital
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headline:High expression of survivin predicts poor prognosis in esophageal squamous cell carcinoma following radiotherapy
description:Radiotherapy is one of the main treatments for esophageal squamous cell carcinoma, but there are still no biomarkers to differentiate patients who will benefit from radiation. Although treatment with a combination of radiotherapy with chemotherapy, and/or surgery improves the prognosis of patients, no biomarkers can distinguish between the responses obtained with the combined therapies. Therefore, in this study, we selected patients treated with radiotherapy alone to evaluate survivin as a predictor for radiotherapy. One hundred two biopsy samples collected by endoscopy were immunostained by survivin antibody. Positive staining for survivin was obtained in 60.8% tumor samples. Survivin expression, metastasis, and clinical stage correlated significantly with overall survival. In multivariate analysis, survivin was an independent prognostic factor for predicting overall survival of patients with esophageal cancer. Moreover, in esophageal cancer cell lines, overexpression of survivin reduced the percentage of cell death induced by radiation. Our data indicate that survivin could be a potential predictor to define those patients with esophageal squamous carcinoma who would benefit from radiotherapy.
datePublished:2011-08-09T00:00:00Z
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description:Radiotherapy is one of the main treatments for esophageal squamous cell carcinoma, but there are still no biomarkers to differentiate patients who will benefit from radiation. Although treatment with a combination of radiotherapy with chemotherapy, and/or surgery improves the prognosis of patients, no biomarkers can distinguish between the responses obtained with the combined therapies. Therefore, in this study, we selected patients treated with radiotherapy alone to evaluate survivin as a predictor for radiotherapy. One hundred two biopsy samples collected by endoscopy were immunostained by survivin antibody. Positive staining for survivin was obtained in 60.8% tumor samples. Survivin expression, metastasis, and clinical stage correlated significantly with overall survival. In multivariate analysis, survivin was an independent prognostic factor for predicting overall survival of patients with esophageal cancer. Moreover, in esophageal cancer cell lines, overexpression of survivin reduced the percentage of cell death induced by radiation. Our data indicate that survivin could be a potential predictor to define those patients with esophageal squamous carcinoma who would benefit from radiotherapy.
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