Here's how LINK.SPRINGER.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s13277-011-0217-y.

Title:
High expression of survivin predicts poor prognosis in esophageal squamous cell carcinoma following radiotherapy | Tumor Biology
Description:
Radiotherapy is one of the main treatments for esophageal squamous cell carcinoma, but there are still no biomarkers to differentiate patients who will benefit from radiation. Although treatment with a combination of radiotherapy with chemotherapy, and/or surgery improves the prognosis of patients, no biomarkers can distinguish between the responses obtained with the combined therapies. Therefore, in this study, we selected patients treated with radiotherapy alone to evaluate survivin as a predictor for radiotherapy. One hundred two biopsy samples collected by endoscopy were immunostained by survivin antibody. Positive staining for survivin was obtained in 60.8% tumor samples. Survivin expression, metastasis, and clinical stage correlated significantly with overall survival. In multivariate analysis, survivin was an independent prognostic factor for predicting overall survival of patients with esophageal cancer. Moreover, in esophageal cancer cell lines, overexpression of survivin reduced the percentage of cell death induced by radiation. Our data indicate that survivin could be a potential predictor to define those patients with esophageal squamous carcinoma who would benefit from radiotherapy.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {šŸ“š}

  • Education
  • Science
  • Health & Fitness

Content Management System {šŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {šŸ’ø}

We can't tell how the site generates income.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {šŸ”}

cancer, article, survivin, google, scholar, pubmed, cas, cell, esophageal, carcinoma, expression, squamous, radiotherapy, patients, prognostic, prognosis, wang, access, research, zhu, china, privacy, cookies, content, zhang, radiation, oesophageal, chinese, gene, nuclear, int, data, publish, search, tumor, quan, liu, zefen, xiao, open, molecular, oncol, altieri, peoples, republic, author, analysis, information, log, journal,

Topics {āœ’ļø}

wencheng zhangĀ &Ā zefen xiao therapy-induced cellular senescence squamous cell carcinoma month download article/chapter esophageal squamous carcinoma small-cell lung cancer pathway-directed drug discovery tumor-specific gene expression zefen xiao related subjects anti-apoptosis gene full article pdf cell death induced unresectable stage iii small-molecule suppressor oesophageal carcinoma renal cell cancer altieri dc privacy choices/manage cookies mol cell biochem ec9706 cell line high survivin expression esophageal cancer cells radiation therapy radiation oncology article zhu check access state key laboratory instant access nuclear survivin expression professor mingrong wang global cancer statistics cancer chemother pharmacol independent prognostic factor good prognostic biomarker splice variant expression intratumoral survivin expression advanced solid tumors nat rev cancer european economic area candidate genes involved response-predictive genes dna damage repair accurate prognostic marker conditions privacy policy biopsy samples collected continuous fractionated irradiation cancer therapeutic target article log sichuan cancer hospital

Schema {šŸ—ŗļø}

WebPage:
      mainEntity:
         headline:High expression of survivin predicts poor prognosis in esophageal squamous cell carcinoma following radiotherapy
         description:Radiotherapy is one of the main treatments for esophageal squamous cell carcinoma, but there are still no biomarkers to differentiate patients who will benefit from radiation. Although treatment with a combination of radiotherapy with chemotherapy, and/or surgery improves the prognosis of patients, no biomarkers can distinguish between the responses obtained with the combined therapies. Therefore, in this study, we selected patients treated with radiotherapy alone to evaluate survivin as a predictor for radiotherapy. One hundred two biopsy samples collected by endoscopy were immunostained by survivin antibody. Positive staining for survivin was obtained in 60.8% tumor samples. Survivin expression, metastasis, and clinical stage correlated significantly with overall survival. In multivariate analysis, survivin was an independent prognostic factor for predicting overall survival of patients with esophageal cancer. Moreover, in esophageal cancer cell lines, overexpression of survivin reduced the percentage of cell death induced by radiation. Our data indicate that survivin could be a potential predictor to define those patients with esophageal squamous carcinoma who would benefit from radiotherapy.
         datePublished:2011-08-09T00:00:00Z
         dateModified:2011-08-09T00:00:00Z
         pageStart:1147
         pageEnd:1153
         sameAs:https://doi.org/10.1007/s13277-011-0217-y
         keywords:
            Survivin
            Esophageal squamous cell carcinoma
            Radiotherapy
            Cancer survival
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-011-0217-y/MediaObjects/13277_2011_217_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-011-0217-y/MediaObjects/13277_2011_217_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-011-0217-y/MediaObjects/13277_2011_217_Fig3_HTML.gif
         isPartOf:
            name:Tumor Biology
            issn:
               1423-0380
               1010-4283
            volumeNumber:32
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Hongxia Zhu
               affiliation:
                     name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                     address:
                        name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Qifeng Wang
               affiliation:
                     name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                     address:
                        name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:Sichuan Cancer Hospital
                     address:
                        name:Department of Radiotherapy, Sichuan Cancer Hospital, Chengdu, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chenfei Hu
               affiliation:
                     name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                     address:
                        name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wencheng Zhang
               affiliation:
                     name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                     address:
                        name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lanping Quan
               affiliation:
                     name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                     address:
                        name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mei Liu
               affiliation:
                     name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                     address:
                        name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ningzhi Xu
               affiliation:
                     name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                     address:
                        name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zefen Xiao
               affiliation:
                     name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                     address:
                        name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:High expression of survivin predicts poor prognosis in esophageal squamous cell carcinoma following radiotherapy
      description:Radiotherapy is one of the main treatments for esophageal squamous cell carcinoma, but there are still no biomarkers to differentiate patients who will benefit from radiation. Although treatment with a combination of radiotherapy with chemotherapy, and/or surgery improves the prognosis of patients, no biomarkers can distinguish between the responses obtained with the combined therapies. Therefore, in this study, we selected patients treated with radiotherapy alone to evaluate survivin as a predictor for radiotherapy. One hundred two biopsy samples collected by endoscopy were immunostained by survivin antibody. Positive staining for survivin was obtained in 60.8% tumor samples. Survivin expression, metastasis, and clinical stage correlated significantly with overall survival. In multivariate analysis, survivin was an independent prognostic factor for predicting overall survival of patients with esophageal cancer. Moreover, in esophageal cancer cell lines, overexpression of survivin reduced the percentage of cell death induced by radiation. Our data indicate that survivin could be a potential predictor to define those patients with esophageal squamous carcinoma who would benefit from radiotherapy.
      datePublished:2011-08-09T00:00:00Z
      dateModified:2011-08-09T00:00:00Z
      pageStart:1147
      pageEnd:1153
      sameAs:https://doi.org/10.1007/s13277-011-0217-y
      keywords:
         Survivin
         Esophageal squamous cell carcinoma
         Radiotherapy
         Cancer survival
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-011-0217-y/MediaObjects/13277_2011_217_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-011-0217-y/MediaObjects/13277_2011_217_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-011-0217-y/MediaObjects/13277_2011_217_Fig3_HTML.gif
      isPartOf:
         name:Tumor Biology
         issn:
            1423-0380
            1010-4283
         volumeNumber:32
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Hongxia Zhu
            affiliation:
                  name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                  address:
                     name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Qifeng Wang
            affiliation:
                  name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                  address:
                     name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Sichuan Cancer Hospital
                  address:
                     name:Department of Radiotherapy, Sichuan Cancer Hospital, Chengdu, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chenfei Hu
            affiliation:
                  name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                  address:
                     name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wencheng Zhang
            affiliation:
                  name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                  address:
                     name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lanping Quan
            affiliation:
                  name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                  address:
                     name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mei Liu
            affiliation:
                  name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                  address:
                     name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ningzhi Xu
            affiliation:
                  name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                  address:
                     name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zefen Xiao
            affiliation:
                  name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
                  address:
                     name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Tumor Biology
      issn:
         1423-0380
         1010-4283
      volumeNumber:32
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
      address:
         name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
         type:PostalAddress
      name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
      address:
         name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
         type:PostalAddress
      name:Sichuan Cancer Hospital
      address:
         name:Department of Radiotherapy, Sichuan Cancer Hospital, Chengdu, People’s Republic of China
         type:PostalAddress
      name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
      address:
         name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
         type:PostalAddress
      name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
      address:
         name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
         type:PostalAddress
      name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
      address:
         name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
         type:PostalAddress
      name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
      address:
         name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
         type:PostalAddress
      name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
      address:
         name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
         type:PostalAddress
      name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
      address:
         name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Hongxia Zhu
      affiliation:
            name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
            address:
               name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Qifeng Wang
      affiliation:
            name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
            address:
               name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Sichuan Cancer Hospital
            address:
               name:Department of Radiotherapy, Sichuan Cancer Hospital, Chengdu, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Chenfei Hu
      affiliation:
            name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
            address:
               name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Wencheng Zhang
      affiliation:
            name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
            address:
               name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Lanping Quan
      affiliation:
            name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
            address:
               name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Mei Liu
      affiliation:
            name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
            address:
               name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Ningzhi Xu
      affiliation:
            name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
            address:
               name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Zefen Xiao
      affiliation:
            name:Cancer Institute and Hospital, Chinese Academy of Medical Sciences
            address:
               name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
      name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
      name:Department of Radiotherapy, Sichuan Cancer Hospital, Chengdu, People’s Republic of China
      name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
      name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
      name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
      name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
      name:Laboratory of Cell and Molecular Biology, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
      name:Department of Radiation Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {šŸ”—}(116)

Analytics and Tracking {šŸ“Š}

  • Google Tag Manager

Libraries {šŸ“š}

  • Clipboard.js
  • Prism.js

CDN Services {šŸ“¦}

  • Crossref

3.6s.