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We began analyzing https://link.springer.com/article/10.1007/s11357-024-01147-7, but it redirected us to https://link.springer.com/article/10.1007/s11357-024-01147-7. The analysis below is for the second page.

Title[redir]:
Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans | GeroScience
Description:
Reduced insulin/IGF-1 signalling (rIIS) improves survival across diverse taxa and there is a growing interest in its role in regulating immune function. Whilst rIIS can improve anti-bacterial resistance, the consequences for anti-viral immunity are yet to be systematically examined. Here, we show that rIIS in adult Caenorhabditis elegans increases the expression of key genes in two different anti-viral immunity pathways, whilst reducing viral load in old age, increasing survival and reducing rate-of-senescence under infection by naturally occurring positive-sense single-stranded RNA Orsay virus. We found that both drh-1 in the anti-viral RNA interference (RNAi) pathway and cde-1 in the terminal uridylation-based degradation of viral RNA pathway were upregulated in early adulthood under rIIS and increased anti-viral resistance was not associated with reproductive costs. Remarkably, rIIS increased anti-viral gene expression only in infected worms, potentially to curb the costs of constitutively upregulated immunity. RNA viruses are found across taxa from plants to mammals and we demonstrate a novel role for rIIS in regulating resistance to viral infection. We therefore highlight this evolutionarily conserved signalling pathway as a promising therapeutic target to improve anti-viral immunity.

Matching Content Categories {📚}

  • Science
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Content Management System {📝}

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Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 98,426,998 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We're unsure if the website is profiting.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

rnai, pubmed, article, viral, google, scholar, infection, daf, antiviral, elegans, virus, survival, expression, day, adulthood, cas, reduced, immunity, reproduction, immune, rna, gene, central, riis, signalling, load, drh, model, iis, fig, treatment, data, cde, infected, individuals, pathways, age, caenorhabditis, orv, orsay, pathway, mortality, agespecific, longevity, absence, experimental, lifespan, ageing, increased, worms,

Topics {✒️}

n-ras-pi3k-akt-mtor pathway signaling-abortive anti-sars-cov-2 defense incomplete mark–recapture/recovery data single-stranded viral rna open access license disentangling life-history trade-offs cost-free anti-viral immunity anti-viral defence systems stress-related pathway components article download pdf boost anti-viral defence immunologie de marseille-luminy fed late-l4 larvae horizontal faecal-oral transmission[25 zoe de pasquale-crighton anti-viral rna interference circumvent parasite-induced reduction terminal uridylation-based degradation double-stranded rna anti-viral immune pathway nutrient-sensing iis pathway insulin/igf-1 signalling rna-based antiviral immunity normalised anti-viral gene anti-viral defence mechanisms rna helicase rig female-biased sex ratio improve anti-bacterial resistance improve anti-viral resistance anti-viral gene expression improve anti-viral immunity anti-viral immune pathways anti-viral immune response kullback–leibler divergence calibration time-staggered independent blocks anti-viral immunity pathways anti-viral transcriptional response qrt-pcr cycle thresholds increased anti-viral resistance rnai-based innate immunity caenorhabditis elegans rig shapiro–wilk normality test cellular integrity life history trade-offs anti-viral immune upregulation anti-viral rnai pathways naturally occurring polymorphism late-l4 orv-infected represents age-independent mortality innate immune system

Questions {❓}

  • Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes?
  • Immunosenescence and its hallmarks: how to oppose aging strategically?
  • Trade-offs in evolutionary immunology: just what is the cost of immunity?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans
         description:Reduced insulin/IGF-1 signalling (rIIS) improves survival across diverse taxa and there is a growing interest in its role in regulating immune function. Whilst rIIS can improve anti-bacterial resistance, the consequences for anti-viral immunity are yet to be systematically examined. Here, we show that rIIS in adult Caenorhabditis elegans increases the expression of key genes in two different anti-viral immunity pathways, whilst reducing viral load in old age, increasing survival and reducing rate-of-senescence under infection by naturally occurring positive-sense single-stranded RNA Orsay virus. We found that both drh-1 in the anti-viral RNA interference (RNAi) pathway and cde-1 in the terminal uridylation-based degradation of viral RNA pathway were upregulated in early adulthood under rIIS and increased anti-viral resistance was not associated with reproductive costs. Remarkably, rIIS increased anti-viral gene expression only in infected worms, potentially to curb the costs of constitutively upregulated immunity. RNA viruses are found across taxa from plants to mammals and we demonstrate a novel role for rIIS in regulating resistance to viral infection. We therefore highlight this evolutionarily conserved signalling pathway as a promising therapeutic target to improve anti-viral immunity.
         datePublished:2024-04-08T00:00:00Z
         dateModified:2024-04-08T00:00:00Z
         pageStart:5767
         pageEnd:5780
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s11357-024-01147-7
         keywords:
            Insulin signalling
            Anti-viral immunity
            Healthy aging
            Orsay RNA virus
            Rate-of-senescence
            Cell Biology
            Geriatrics/Gerontology
            Molecular Medicine
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            issn:
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               name:Elizabeth M. L. Duxbury
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                     name:University of East Anglia
                     address:
                        name:School of Biological Sciences, University of East Anglia, Norwich, UK
                        type:PostalAddress
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ScholarlyArticle:
      headline:Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans
      description:Reduced insulin/IGF-1 signalling (rIIS) improves survival across diverse taxa and there is a growing interest in its role in regulating immune function. Whilst rIIS can improve anti-bacterial resistance, the consequences for anti-viral immunity are yet to be systematically examined. Here, we show that rIIS in adult Caenorhabditis elegans increases the expression of key genes in two different anti-viral immunity pathways, whilst reducing viral load in old age, increasing survival and reducing rate-of-senescence under infection by naturally occurring positive-sense single-stranded RNA Orsay virus. We found that both drh-1 in the anti-viral RNA interference (RNAi) pathway and cde-1 in the terminal uridylation-based degradation of viral RNA pathway were upregulated in early adulthood under rIIS and increased anti-viral resistance was not associated with reproductive costs. Remarkably, rIIS increased anti-viral gene expression only in infected worms, potentially to curb the costs of constitutively upregulated immunity. RNA viruses are found across taxa from plants to mammals and we demonstrate a novel role for rIIS in regulating resistance to viral infection. We therefore highlight this evolutionarily conserved signalling pathway as a promising therapeutic target to improve anti-viral immunity.
      datePublished:2024-04-08T00:00:00Z
      dateModified:2024-04-08T00:00:00Z
      pageStart:5767
      pageEnd:5780
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s11357-024-01147-7
      keywords:
         Insulin signalling
         Anti-viral immunity
         Healthy aging
         Orsay RNA virus
         Rate-of-senescence
         Cell Biology
         Geriatrics/Gerontology
         Molecular Medicine
      image:
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-024-01147-7/MediaObjects/11357_2024_1147_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-024-01147-7/MediaObjects/11357_2024_1147_Fig4_HTML.png
      isPartOf:
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         issn:
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         name:Springer International Publishing
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            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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      author:
            name:Elizabeth M. L. Duxbury
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                  name:University of East Anglia
                  address:
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                     type:PostalAddress
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            type:Person
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                  name:University of East Anglia
                  address:
                     name:School of Biological Sciences, University of East Anglia, Norwich, UK
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                  type:Organization
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                  name:University of East Anglia
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                     name:School of Biological Sciences, University of East Anglia, Norwich, UK
                     type:PostalAddress
                  type:Organization
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            affiliation:
                  name:University of East Anglia
                  address:
                     name:School of Biological Sciences, University of East Anglia, Norwich, UK
                     type:PostalAddress
                  type:Organization
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            name:Katie Johnson
            affiliation:
                  name:University of East Anglia
                  address:
                     name:School of Biological Sciences, University of East Anglia, Norwich, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alexei A. Maklakov
            affiliation:
                  name:University of East Anglia
                  address:
                     name:School of Biological Sciences, University of East Anglia, Norwich, UK
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               name:School of Biological Sciences, University of East Anglia, Norwich, UK
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            address:
               name:School of Biological Sciences, University of East Anglia, Norwich, UK
               type:PostalAddress
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      affiliation:
            name:University of East Anglia
            address:
               name:School of Biological Sciences, University of East Anglia, Norwich, UK
               type:PostalAddress
            type:Organization
      name:Katie Johnson
      affiliation:
            name:University of East Anglia
            address:
               name:School of Biological Sciences, University of East Anglia, Norwich, UK
               type:PostalAddress
            type:Organization
      name:Alexei A. Maklakov
      affiliation:
            name:University of East Anglia
            address:
               name:School of Biological Sciences, University of East Anglia, Norwich, UK
               type:PostalAddress
            type:Organization
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      name:School of Biological Sciences, University of East Anglia, Norwich, UK
      name:School of Biological Sciences, University of East Anglia, Norwich, UK
      name:School of Biological Sciences, University of East Anglia, Norwich, UK
      name:School of Biological Sciences, University of East Anglia, Norwich, UK
      name:School of Biological Sciences, University of East Anglia, Norwich, UK
      name:School of Biological Sciences, University of East Anglia, Norwich, UK

External Links {🔗}(396)

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