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We began analyzing https://link.springer.com/article/10.1007/s10911-009-9111-2, but it redirected us to https://link.springer.com/article/10.1007/s10911-009-9111-2. The analysis below is for the second page.

Title[redir]:
Cellular Quiescence in Mammary Stem Cells and Breast Tumor Stem Cells: Got Testable Hypotheses? | Journal of Mammary Gland Biology and Neoplasia
Description:
Cellular quiescence is a state of reversible cell cycle arrest and has more recently been shown to be a blockade to differentiation and to correlate with resistance to cancer chemotherapeutics and other xenobiotics; features that are common to adult stem cells and possibly tumor stem cells. The biphasic kinetics of mammary regeneration, coupled to its cyclic endocrine control suggest that mammary stem cells most likely divide during a narrow window of the regenerative cycle and return to a state of quiescence. This would enable them to retain their proliferative capacity, resist differentiation signals and preserve their prolonged life span. There is accumulating evidence that mammary stem cells and other adult stem cells utilize quiescence for this purpose, however the degree to which tumor stem cells do so is largely unknown. The retained proliferative capacity of mammary stem cells likely enables them to accumulate and harbor mutations that lead to breast cancer initiation. However it is currently unclear if these causative lesions lead to defective or deranged quiescence in mammary stem cells. Evidence of such effects could potentially lead to the development of diagnostic systems that monitor mammary stem cell quiescence or activation. Such systems may be useful for the evaluation of patients who are at significant risk of breast cancer. Additionally quiescence has been postulated to contribute to therapeutic resistance and tumor recurrence. This review aims to evaluate what is known about the mechanisms governing cellular quiescence and the role of tumor stem cell quiescence in breast cancer recurrence.

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Keywords {🔍}

article, pubmed, google, scholar, cas, cells, stem, cell, cancer, mammary, quiescence, breast, human, tumor, cellular, biol, nature, gland, biology, cycle, gene, res, proliferation, retinoblastoma, privacy, cookies, content, journal, differentiation, resistance, access, progenitor, dev, normal, nat, signaling, notch, publish, search, direnzo, state, activation, therapeutic, growth, abcg, doinature, hematopoietic, expression, clin, tumorigenic,

Topics {✒️}

month download article/chapter adult stem cells atp-binding cassette proteins luminal cell-fate commitment mammary stem cells asymmetric cell division canonical notch/rbp human breast cancer full article pdf cancer stem cells cell stem cell human hematopoietic stem hematopoietic stem cells transgenic mice leads tumor stem cells haematopoietic stem cells functional mammary gland human glioblastoma cells privacy choices/manage cookies single stem cell intestinal stem cell mammary gland biology stem-cell biology retinoblastoma gene protein abcg2− cancer cells skin stem cells nat rev cancer breast cancer initiation breast cancer recurrence breast cancer res hedgehog signaling induces mammary tumors early premalignant lesions bmp receptor ia cell cycle state notch signaling harmes & james direnzo natl cancer inst swiss 3t3 cells retinoblastoma gene function progenitor cell regulation nfatc1 balances quiescence coller ha proliferative merkel cells nat cell biol therapeutic resistance cells tissues organs signaling pathway controls article harmes dna tumor viruses

Questions {❓}

Cellular Quiescence in Mammary Stem Cells and Breast Tumor Stem Cells: Got Testable Hypotheses?
Cellular Quiescence in Mammary Stem Cells and Breast Tumor Stem Cells: Got Testable Hypotheses?
What’s taking so long?

Schema {🗺️}

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         description:Cellular quiescence is a state of reversible cell cycle arrest and has more recently been shown to be a blockade to differentiation and to correlate with resistance to cancer chemotherapeutics and other xenobiotics; features that are common to adult stem cells and possibly tumor stem cells. The biphasic kinetics of mammary regeneration, coupled to its cyclic endocrine control suggest that mammary stem cells most likely divide during a narrow window of the regenerative cycle and return to a state of quiescence. This would enable them to retain their proliferative capacity, resist differentiation signals and preserve their prolonged life span. There is accumulating evidence that mammary stem cells and other adult stem cells utilize quiescence for this purpose, however the degree to which tumor stem cells do so is largely unknown. The retained proliferative capacity of mammary stem cells likely enables them to accumulate and harbor mutations that lead to breast cancer initiation. However it is currently unclear if these causative lesions lead to defective or deranged quiescence in mammary stem cells. Evidence of such effects could potentially lead to the development of diagnostic systems that monitor mammary stem cell quiescence or activation. Such systems may be useful for the evaluation of patients who are at significant risk of breast cancer. Additionally quiescence has been postulated to contribute to therapeutic resistance and tumor recurrence. This review aims to evaluate what is known about the mechanisms governing cellular quiescence and the role of tumor stem cell quiescence in breast cancer recurrence.
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