We are analyzing https://link.springer.com/article/10.1186/ar14.

Title:
Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis | Arthritis Research & Therapy
Description:
Destruction of cartilage and bone are hallmarks of human rheumatoid arthritis (RA), and controlling these erosive processes is the most challenging objective in the treatment of RA. Systemic interleukin-4 treatment of established murine collagen-induced arthritis suppressed disease activity and protected against cartilage and bone destruction. Reduced cartilage pathology was confirmed by both decreased serum cartilage oligomeric matrix protein (COMP) and histological examination. In addition, radiological analysis revealed that bone destruction was also partially prevented. Improved suppression of joint swelling was achieved when interleukin-4 treatment was combined with low-dose prednisolone treatment. Interestingly, synergistic reduction of both serum COMP and inflammatory parameters was noted when low-dose interleukin-4 was combined with prednisolone. Systemic treatment with interleukin-4 appeared to be a protective therapy for cartilage and bone in arthritis, and in combination with prednisolone at low dosages may offer an alternative therapy in RA.
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Keywords {🔍}

arthritis, cartilage, treatment, bone, google, scholar, article, destruction, levels, interleukin, cia, serum, pubmed, comp, mice, effect, type, joint, prednisolone, disease, cells, murine, reduced, ilprednisolone, activity, matrix, μgday, ilra, established, cytokine, collageninduced, collagen, treated, suppression, production, day, van, human, effects, anticollagen, found, lowdose, knee, cytokines, onset, figure, expression, antibodies, animals, oligomeric,

Topics {✒️}

pleiotropic t-cell-derived cytokine b-cell stimulatory factor-1/interleukin-4 phosphate-buffered slaine-tween il-1-receptor type ii anti-il-4/anti-il-10 shortly pleiotropic t-cellderived cytokine b-cell growth factor murine collagen-induced arthritis neo-epitope vdipen correlated including steroid-induced osteoporosis murine antigen-induced arthritis collagen type ii low-dose il-4/prednisolone treatment serum il-1ra levels phosphate-buffered saline metalloproteinase-generated neoepitope vdipen asn341-phe342 site coincides antimurine il-1ra antibodies enzyme-linked immunosorbent assay il-4-induced immune deviation coordinated anti-inflammatory effects human articular chon-drocytes recombinant murine il-1ra nitric oxide inhibitors il-1β-deficient mice lower il-1ra levels tnf-receptor-deficient mice potent anti-inflammatory cytokine low-dose prednisolone enhanced potent anti-inflammatory effects achieved withil-4/prednisolone treatment potential anti-inflammatory effects nitric oxide mediated bovine serum albumin th1/th2 cytokine balances de vries je interleukin-1 receptor antagonist uneven th1/th2 balance il-4/prednisolone completely arrested low-dose il-4 showed increased serum levels collagen-induced arthritis low-dose prednisolone treatment full-blown expression improved anti-inflammatory effect tumour necrosis factor inhibit tnf/il-1 production murine collagen arthritis indicating decreased formation privacy choices/manage cookies

Schema {🗺️}

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         headline:Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis
         description:Destruction of cartilage and bone are hallmarks of human rheumatoid arthritis (RA), and controlling these erosive processes is the most challenging objective in the treatment of RA. Systemic interleukin-4 treatment of established murine collagen-induced arthritis suppressed disease activity and protected against cartilage and bone destruction. Reduced cartilage pathology was confirmed by both decreased serum cartilage oligomeric matrix protein (COMP) and histological examination. In addition, radiological analysis revealed that bone destruction was also partially prevented. Improved suppression of joint swelling was achieved when interleukin-4 treatment was combined with low-dose prednisolone treatment. Interestingly, synergistic reduction of both serum COMP and inflammatory parameters was noted when low-dose interleukin-4 was combined with prednisolone. Systemic treatment with interleukin-4 appeared to be a protective therapy for cartilage and bone in arthritis, and in combination with prednisolone at low dosages may offer an alternative therapy in RA.
         datePublished:1999-10-26T00:00:00Z
         dateModified:1999-10-26T00:00:00Z
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            cartilage oligomeric matrix protein levels
            collagen-induced arthritis
            interleukin-4
            prednisolone
            Rheumatology
            Orthopedics
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      headline:Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis
      description:Destruction of cartilage and bone are hallmarks of human rheumatoid arthritis (RA), and controlling these erosive processes is the most challenging objective in the treatment of RA. Systemic interleukin-4 treatment of established murine collagen-induced arthritis suppressed disease activity and protected against cartilage and bone destruction. Reduced cartilage pathology was confirmed by both decreased serum cartilage oligomeric matrix protein (COMP) and histological examination. In addition, radiological analysis revealed that bone destruction was also partially prevented. Improved suppression of joint swelling was achieved when interleukin-4 treatment was combined with low-dose prednisolone treatment. Interestingly, synergistic reduction of both serum COMP and inflammatory parameters was noted when low-dose interleukin-4 was combined with prednisolone. Systemic treatment with interleukin-4 appeared to be a protective therapy for cartilage and bone in arthritis, and in combination with prednisolone at low dosages may offer an alternative therapy in RA.
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      dateModified:1999-10-26T00:00:00Z
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      pageEnd:11
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         bone destruction
         cartilage oligomeric matrix protein levels
         collagen-induced arthritis
         interleukin-4
         prednisolone
         Rheumatology
         Orthopedics
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