We are analyzing https://link.springer.com/article/10.1007/s10552-009-9434-8.

Title:
Association between plasma total cholesterol concentration and incident prostate cancer in the CLUE II cohort | Cancer Causes & Control
Description:
Statin drugs appear to protect against advanced and possibly high-grade prostate cancer, perhaps through cholesterol-lowering. Thus, we evaluated the association between plasma cholesterol and prostate cancer. We conducted a prospective study in the CLUE II cohort of Washington County, MD. Included were 6,816 male county residents aged 35+ years old who did not have a cancer diagnosis at baseline in 1989. Plasma cholesterol, measured enzymatically at baseline, was categorized by clinical cutpoints. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total (n = 438) and high-grade (Gleason sum ≥7, n = 137) prostate cancer. Compared to men with high cholesterol (≥240 mg/dl), men with desirable (<200 mg/dl) or borderline (200 to <240 mg/dl) levels were less likely to develop high-grade prostate cancer, particularly when restricting to organ-confined cases (HR: 0.68, 95% CI 0.40–1.18; P trend = 0.12) and among men with higher BMI (HR: 0.36, 95% CI 0.16–0.79; P trend = 0.02). Results were unchanged after excluding cholesterol-lowering drug users. Cholesterol was not associated with total prostate cancer. Our study supports two prior ones suggesting that cholesterol influences risk of high-grade prostate cancer, and indirectly supports the hypothesis that cholesterol-lowering is a mechanism by which statins are protective.
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cancer, prostate, google, scholar, article, cholesterol, risk, pubmed, cas, association, epidemiol, study, cohort, platz, serum, health, national, research, plasma, content, helzlsouer, cholesterollowering, men, prev, usa, privacy, cookies, total, mondul, kathy, elizabeth, highgrade, statins, access, prostatic, biomarkers, institute, data, publish, search, clue, clipp, statin, drugs, prevention, american, incidence, mortality, johns, hopkins,

Topics {✒️}

month download article/chapter population-based case–control study high-grade prostate cancer related subjects full article pdf privacy choices/manage cookies clue ii cohort incident prostate cancer total prostate cancer prostate cancer—hype prostate cancer progression prostatic cancer advanced prostate cancer case–control study american heart association prostate cancer risk platz ea data-based approach national cancer institute plasma cholesterol concentration european economic area organ-confined cases c-reactive protein van dijk ce dutch civil servants body mass index diet questionnaire design mercy medical center article cancer cholesterol-lowering drugs cholesterol-lowering properties conditions privacy policy trends endocrinol metab low plasma cholesterol familial combined hyperlipidemia prospective basel study serum total cholesterol low serum cholesterol public health research noncardiovascular disease mortality health study cohort accepting optional cookies flick ed site-specific cancers cholesterol influences risk check access instant access high-grade helzlsouer prevention article log

Questions {❓}

Solomon KR, Freeman MR (2008) Do the cholesterol-lowering properties of statins affect cancer risk?
Statins and prostate cancer—hype or hope?

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