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We began analyzing https://link.springer.com/article/10.1007/s10549-018-4834-7, but it redirected us to https://link.springer.com/article/10.1007/s10549-018-4834-7. The analysis below is for the second page.

Title[redir]:
The combined presence of CD20 + B cells and PD-L1 + tumor-infiltrating lymphocytes in inflammatory breast cancer is prognostic of improved patient outcome | Breast Cancer Research and Treatment
Description:
Purpose The purpose of the study was to evaluate protein expression of PD-L1 and CD20 as prognostic biomarkers of patient outcome in inflammatory breast cancer (IBC) samples. Methods PD-L1 and CD20 protein expression was measured by immunohistochemistry in 221 pretreatment IBC biopsies. PD-L1 was assessed in tumor cells (PD-L1+ tumor cells) and tumor stromal infiltrating lymphocytes (PD-L1+ TILs); CD20 was scored in tumor-infiltrating B cells. Kaplan–Meier curves and Cox proportional hazard models were used for survival analysis. Results PD-L1+ tumor cells, PD-L1+ TILs, and CD20+ TILs were found in 8%, 66%, and 62% of IBC, respectively. PD-L1+ tumor cells strongly correlated with high TILs, pathological complete response (pCR), CD20+ TILs, but marginally with breast cancer-specific survival (BCSS, P = 0.057). PD-L1+ TILs strongly correlated with high TILs, CD20+ TILs, and longer disease-free survival (DFS) in all IBC and in triple-negative (TN) IBC (P < 0.035). IBC and TN IBC patients with tumors containing both CD20+ TILs and PD-L1+ TILs (CD20+TILs/PD-L1+TILs) showed longer DFS and improved BCSS (P < 0.002) than patients lacking both, or those with either CD20+ TILs or PD-L1+ TILs alone. In multivariate analyses, CD20+TILs/PD-L1+TILs status was an independent prognostic factor for DFS in IBC (hazard ratio (HR): 0.53, 95% CI 0.37–0.77) and TN IBC (HR: 0.39 95% CI 0.17–0.88), and for BCSS in IBC (HR: 0.60 95% CI 0.43–0.85) and TN IBC (HR: 0.38 95% CI 0.17–0.83). Conclusion CD20+TILs/PD-L1+TILs status represents an independent favorable prognostic factor in IBC and TN IBC, suggesting a critical role for B cells in antitumor immune responses. Anti-PD-1/PD-L1 and B cell-activating immunotherapies should be explored in these settings.

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

cancer, breast, article, pubmed, google, scholar, pdl, tils, inflammatory, ibc, cas, cells, central, lymphocytes, prognostic, expression, survival, patients, res, tumorinfiltrating, outcome, research, study, httpsdoiorgs, clin, medicine, ariaspulido, tumor, response, death, improved, chaher, bcss, dfs, triplenegative, access, programmed, chemotherapy, oncol, center, usa, supplementary, material, privacy, cookies, content, analysis, ciminomathews, immune, treat,

Topics {✒️}

cd20+tils/pd-l1+tils status anti-pd-l1 antibody mpdl3280a pd-l1 + tumor-infiltrating lymphocytes month download article/chapter tumour-infiltrating lymphocytes cd20+tils/pd-l1+tils triple-negative breast cancer prognostic b-cell signatures anti-pd-1/pd-l1 pd-l1+ immune cells pd-l1+ tumor cells long-term clinical benefit independent prognostic factor large population-based study methods pd-l1 breast cancer-specific survival kaplan-meier survival estimates improved patient outcome oncology meets immunology full article pdf longer disease-free survival related subjects pd-l1 expression anti–pd-1 antibody pd-l1+ tils tumor–infiltrating lymphocytes tumor-infiltrating lymphocytes inflammatory breast cancer stage iii inflammatory immunogenic cell death privacy choices/manage cookies cell-activating immunotherapies article arias-pulido human breast cancer patient outcome multiplexed quantitative analysis triple-negative subtype-specific breast antitumor immune responses ctneobc pooled analysis kaplan–meier curves check access instant access increased tils open-label disease-free survival iridium cancer net end results program end results database geyer ce jr

Questions {❓}

  • Gonzalez-Angulo AM, Hennessy BT, Broglio K, Meric-Bernstam F, Cristofanilli M, Giordano SH, Buchholz TA, Sahin A, Singletary SE, Buzdar AU, Hortobagyi GN (2007) Trends for Inflammatory Breast Cancer: Is Survival Improving?

Schema {🗺️}

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         headline:The combined presence of CD20 + B cells and PD-L1 + tumor-infiltrating lymphocytes in inflammatory breast cancer is prognostic of improved patient outcome
         description:The purpose of the study was to evaluate protein expression of PD-L1 and CD20 as prognostic biomarkers of patient outcome in inflammatory breast cancer (IBC) samples. PD-L1 and CD20 protein expression was measured by immunohistochemistry in 221 pretreatment IBC biopsies. PD-L1 was assessed in tumor cells (PD-L1+ tumor cells) and tumor stromal infiltrating lymphocytes (PD-L1+ TILs); CD20 was scored in tumor-infiltrating B cells. Kaplan–Meier curves and Cox proportional hazard models were used for survival analysis. PD-L1+ tumor cells, PD-L1+ TILs, and CD20+ TILs were found in 8%, 66%, and 62% of IBC, respectively. PD-L1+ tumor cells strongly correlated with high TILs, pathological complete response (pCR), CD20+ TILs, but marginally with breast cancer-specific survival (BCSS, P = 0.057). PD-L1+ TILs strongly correlated with high TILs, CD20+ TILs, and longer disease-free survival (DFS) in all IBC and in triple-negative (TN) IBC (P &lt; 0.035). IBC and TN IBC patients with tumors containing both CD20+ TILs and PD-L1+ TILs (CD20+TILs/PD-L1+TILs) showed longer DFS and improved BCSS (P &lt; 0.002) than patients lacking both, or those with either CD20+ TILs or PD-L1+ TILs alone. In multivariate analyses, CD20+TILs/PD-L1+TILs status was an independent prognostic factor for DFS in IBC (hazard ratio (HR): 0.53, 95% CI 0.37–0.77) and TN IBC (HR: 0.39 95% CI 0.17–0.88), and for BCSS in IBC (HR: 0.60 95% CI 0.43–0.85) and TN IBC (HR: 0.38 95% CI 0.17–0.83). CD20+TILs/PD-L1+TILs status represents an independent favorable prognostic factor in IBC and TN IBC, suggesting a critical role for B cells in antitumor immune responses. Anti-PD-1/PD-L1 and B cell-activating immunotherapies should be explored in these settings.
         datePublished:2018-06-01T00:00:00Z
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      headline:The combined presence of CD20 + B cells and PD-L1 + tumor-infiltrating lymphocytes in inflammatory breast cancer is prognostic of improved patient outcome
      description:The purpose of the study was to evaluate protein expression of PD-L1 and CD20 as prognostic biomarkers of patient outcome in inflammatory breast cancer (IBC) samples. PD-L1 and CD20 protein expression was measured by immunohistochemistry in 221 pretreatment IBC biopsies. PD-L1 was assessed in tumor cells (PD-L1+ tumor cells) and tumor stromal infiltrating lymphocytes (PD-L1+ TILs); CD20 was scored in tumor-infiltrating B cells. Kaplan–Meier curves and Cox proportional hazard models were used for survival analysis. PD-L1+ tumor cells, PD-L1+ TILs, and CD20+ TILs were found in 8%, 66%, and 62% of IBC, respectively. PD-L1+ tumor cells strongly correlated with high TILs, pathological complete response (pCR), CD20+ TILs, but marginally with breast cancer-specific survival (BCSS, P = 0.057). PD-L1+ TILs strongly correlated with high TILs, CD20+ TILs, and longer disease-free survival (DFS) in all IBC and in triple-negative (TN) IBC (P &lt; 0.035). IBC and TN IBC patients with tumors containing both CD20+ TILs and PD-L1+ TILs (CD20+TILs/PD-L1+TILs) showed longer DFS and improved BCSS (P &lt; 0.002) than patients lacking both, or those with either CD20+ TILs or PD-L1+ TILs alone. In multivariate analyses, CD20+TILs/PD-L1+TILs status was an independent prognostic factor for DFS in IBC (hazard ratio (HR): 0.53, 95% CI 0.37–0.77) and TN IBC (HR: 0.39 95% CI 0.17–0.88), and for BCSS in IBC (HR: 0.60 95% CI 0.43–0.85) and TN IBC (HR: 0.38 95% CI 0.17–0.83). CD20+TILs/PD-L1+TILs status represents an independent favorable prognostic factor in IBC and TN IBC, suggesting a critical role for B cells in antitumor immune responses. Anti-PD-1/PD-L1 and B cell-activating immunotherapies should be explored in these settings.
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      dateModified:2018-06-01T00:00:00Z
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         PD-L1
         CD20
         Immuno-oncology
         Inflammatory breast cancer
         Triple-negative
         Patient outcome
         Oncology
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      name:N. Joste
      affiliation:
            name:The University of New Mexico Comprehensive Cancer Center, and Health Sciences Center
            address:
               name:Departments of Pathology, Mathematics and Statistics, and Internal Medicine, The University of New Mexico Comprehensive Cancer Center, and Health Sciences Center, Albuquerque, USA
               type:PostalAddress
            type:Organization
      name:C. Colpaert
      affiliation:
            name:Iridium Cancer Net
            address:
               name:Department of Pathology, Oncology Centre, GZA Hospitals, Iridium Cancer Net, Antwerp, Belgium
               type:PostalAddress
            type:Organization
      name:J. D. Marotti
      affiliation:
            name:Geisel School of Medicine at Dartmouth
            address:
               name:Pathology and Laboratory Medicine, and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, USA
               type:PostalAddress
            type:Organization
      name:M. Foisey
      affiliation:
            name:Geisel School of Medicine at Dartmouth
            address:
               name:Departments of Microbiology and Immunology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, USA
               type:PostalAddress
            type:Organization
      name:E. R. Prossnitz
      affiliation:
            name:The University of New Mexico Comprehensive Cancer Center, and Health Sciences Center
            address:
               name:Departments of Pathology, Mathematics and Statistics, and Internal Medicine, The University of New Mexico Comprehensive Cancer Center, and Health Sciences Center, Albuquerque, USA
               type:PostalAddress
            type:Organization
      name:L. A. Emens
      affiliation:
            name:The Johns Hopkins University School of Medicine and Bloomberg–Kimmel Institute for Immunotherapy
            address:
               name:Departments of Oncology, The Johns Hopkins University School of Medicine and Bloomberg–Kimmel Institute for Immunotherapy, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:S. Fiering
      affiliation:
            name:Geisel School of Medicine at Dartmouth
            address:
               name:Departments of Microbiology and Immunology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Departments of Microbiology and Immunology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, USA
      name:Departments of Pathology, The Johns Hopkins University School of Medicine and Bloomberg–Kimmel Institute for Immunotherapy, Baltimore, USA
      name:Departments of Oncology, The Johns Hopkins University School of Medicine and Bloomberg–Kimmel Institute for Immunotherapy, Baltimore, USA
      name:Department of Pathology, Centre Pierre et Marie Curie et Faculté de Médecine d’Alger, Algiers, Algeria
      name:Departments of Pathology, Mathematics and Statistics, and Internal Medicine, The University of New Mexico Comprehensive Cancer Center, and Health Sciences Center, Albuquerque, USA
      name:Departments of Pathology, Mathematics and Statistics, and Internal Medicine, The University of New Mexico Comprehensive Cancer Center, and Health Sciences Center, Albuquerque, USA
      name:Department of Pathology, Oncology Centre, GZA Hospitals, Iridium Cancer Net, Antwerp, Belgium
      name:Pathology and Laboratory Medicine, and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, USA
      name:Departments of Microbiology and Immunology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, USA
      name:Departments of Pathology, Mathematics and Statistics, and Internal Medicine, The University of New Mexico Comprehensive Cancer Center, and Health Sciences Center, Albuquerque, USA
      name:Departments of Oncology, The Johns Hopkins University School of Medicine and Bloomberg–Kimmel Institute for Immunotherapy, Baltimore, USA
      name:Departments of Microbiology and Immunology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, USA
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