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Title[redir]:
The combined presence of CD20 + B cells and PD-L1 + tumor-infiltrating lymphocytes in inflammatory breast cancer is prognostic of improved patient outcome | Breast Cancer Research and Treatment
Description:
Purpose The purpose of the study was to evaluate protein expression of PD-L1 and CD20 as prognostic biomarkers of patient outcome in inflammatory breast cancer (IBC) samples. Methods PD-L1 and CD20 protein expression was measured by immunohistochemistry in 221 pretreatment IBC biopsies. PD-L1 was assessed in tumor cells (PD-L1+ tumor cells) and tumor stromal infiltrating lymphocytes (PD-L1+ TILs); CD20 was scored in tumor-infiltrating B cells. Kaplan–Meier curves and Cox proportional hazard models were used for survival analysis. Results PD-L1+ tumor cells, PD-L1+ TILs, and CD20+ TILs were found in 8%, 66%, and 62% of IBC, respectively. PD-L1+ tumor cells strongly correlated with high TILs, pathological complete response (pCR), CD20+ TILs, but marginally with breast cancer-specific survival (BCSS, P = 0.057). PD-L1+ TILs strongly correlated with high TILs, CD20+ TILs, and longer disease-free survival (DFS) in all IBC and in triple-negative (TN) IBC (P < 0.035). IBC and TN IBC patients with tumors containing both CD20+ TILs and PD-L1+ TILs (CD20+TILs/PD-L1+TILs) showed longer DFS and improved BCSS (P < 0.002) than patients lacking both, or those with either CD20+ TILs or PD-L1+ TILs alone. In multivariate analyses, CD20+TILs/PD-L1+TILs status was an independent prognostic factor for DFS in IBC (hazard ratio (HR): 0.53, 95% CI 0.37–0.77) and TN IBC (HR: 0.39 95% CI 0.17–0.88), and for BCSS in IBC (HR: 0.60 95% CI 0.43–0.85) and TN IBC (HR: 0.38 95% CI 0.17–0.83). Conclusion CD20+TILs/PD-L1+TILs status represents an independent favorable prognostic factor in IBC and TN IBC, suggesting a critical role for B cells in antitumor immune responses. Anti-PD-1/PD-L1 and B cell-activating immunotherapies should be explored in these settings.
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Keywords {🔍}
cancer, breast, article, pubmed, google, scholar, pdl, tils, inflammatory, ibc, cas, cells, central, lymphocytes, prognostic, expression, survival, patients, res, tumorinfiltrating, outcome, research, study, httpsdoiorgs, clin, medicine, ariaspulido, tumor, response, death, improved, chaher, bcss, dfs, triplenegative, access, programmed, chemotherapy, oncol, center, usa, supplementary, material, privacy, cookies, content, analysis, ciminomathews, immune, treat,
Topics {✒️}
cd20+tils/pd-l1+tils status anti-pd-l1 antibody mpdl3280a pd-l1 + tumor-infiltrating lymphocytes month download article/chapter tumour-infiltrating lymphocytes cd20+tils/pd-l1+tils triple-negative breast cancer prognostic b-cell signatures anti-pd-1/pd-l1 pd-l1+ immune cells pd-l1+ tumor cells long-term clinical benefit independent prognostic factor large population-based study methods pd-l1 breast cancer-specific survival kaplan-meier survival estimates improved patient outcome oncology meets immunology full article pdf longer disease-free survival related subjects pd-l1 expression anti–pd-1 antibody pd-l1+ tils tumor–infiltrating lymphocytes tumor-infiltrating lymphocytes inflammatory breast cancer stage iii inflammatory immunogenic cell death privacy choices/manage cookies cell-activating immunotherapies article arias-pulido human breast cancer patient outcome multiplexed quantitative analysis triple-negative subtype-specific breast antitumor immune responses ctneobc pooled analysis kaplan–meier curves check access instant access increased tils open-label disease-free survival iridium cancer net end results program end results database geyer ce jr
Questions {❓}
- Gonzalez-Angulo AM, Hennessy BT, Broglio K, Meric-Bernstam F, Cristofanilli M, Giordano SH, Buchholz TA, Sahin A, Singletary SE, Buzdar AU, Hortobagyi GN (2007) Trends for Inflammatory Breast Cancer: Is Survival Improving?
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headline:The combined presence of CD20 + B cells and PD-L1 + tumor-infiltrating lymphocytes in inflammatory breast cancer is prognostic of improved patient outcome
description:The purpose of the study was to evaluate protein expression of PD-L1 and CD20 as prognostic biomarkers of patient outcome in inflammatory breast cancer (IBC) samples. PD-L1 and CD20 protein expression was measured by immunohistochemistry in 221 pretreatment IBC biopsies. PD-L1 was assessed in tumor cells (PD-L1+ tumor cells) and tumor stromal infiltrating lymphocytes (PD-L1+ TILs); CD20 was scored in tumor-infiltrating B cells. Kaplan–Meier curves and Cox proportional hazard models were used for survival analysis. PD-L1+ tumor cells, PD-L1+ TILs, and CD20+ TILs were found in 8%, 66%, and 62% of IBC, respectively. PD-L1+ tumor cells strongly correlated with high TILs, pathological complete response (pCR), CD20+ TILs, but marginally with breast cancer-specific survival (BCSS, P = 0.057). PD-L1+ TILs strongly correlated with high TILs, CD20+ TILs, and longer disease-free survival (DFS) in all IBC and in triple-negative (TN) IBC (P < 0.035). IBC and TN IBC patients with tumors containing both CD20+ TILs and PD-L1+ TILs (CD20+TILs/PD-L1+TILs) showed longer DFS and improved BCSS (P < 0.002) than patients lacking both, or those with either CD20+ TILs or PD-L1+ TILs alone. In multivariate analyses, CD20+TILs/PD-L1+TILs status was an independent prognostic factor for DFS in IBC (hazard ratio (HR): 0.53, 95% CI 0.37–0.77) and TN IBC (HR: 0.39 95% CI 0.17–0.88), and for BCSS in IBC (HR: 0.60 95% CI 0.43–0.85) and TN IBC (HR: 0.38 95% CI 0.17–0.83). CD20+TILs/PD-L1+TILs status represents an independent favorable prognostic factor in IBC and TN IBC, suggesting a critical role for B cells in antitumor immune responses. Anti-PD-1/PD-L1 and B cell-activating immunotherapies should be explored in these settings.
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PD-L1
CD20
Immuno-oncology
Inflammatory breast cancer
Triple-negative
Patient outcome
Oncology
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