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Title[redir]:
Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer | Breast Cancer Research and Treatment
Description:
The purpose of this study is to determine the biologic impact of short-term lipophilic statin exposure on in situ and invasive breast cancer through paired tissue, blood and imaging-based biomarkers. A perioperative window trial of fluvastatin was conducted in women with a diagnosis of DCIS or stage 1 breast cancer. Patients were randomized to high dose (80 mg/day) or low dose (20 mg/day) fluvastatin for 3–6 weeks before surgery. Tissue (diagnostic core biopsy/final surgical specimen), blood, and magnetic resonance images were obtained before/after treatment. The primary endpoint was Ki-67 (proliferation) reduction. Secondary endpoints were change in cleaved caspase-3 (CC3, apoptosis), MRI tumor volume, and serum C-reactive protein (CRP, inflammation). Planned subgroup analyses compared disease grade, statin dose, and estrogen-receptor status. Forty of 45 patients who enrolled completed the protocol; 29 had paired Ki-67 primary endpoint data. Proliferation of high grade tumors decreased by a median of 7.2% (P = 0.008), which was statistically greater than the 0.3% decrease for low grade tumors. Paired data for CC3 showed tumor apoptosis increased in 38%, remained stable in 41%, and decreased in 21% of subjects. More high grade tumors had an increase in apoptosis (60 vs. 13%; P = 0.015). Serum CRP did not change, but cholesterol levels were significantly lower post statin exposure (P < 0.001). Fluvastatin showed measurable biologic changes by reducing tumor proliferation and increasing apoptotic activity in high-grade, stage 0/1 breast cancer. Effects were only evident in high grade tumors. These results support further evaluation of statins as chemoprevention for ER-negative high grade breast cancers.
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Keywords {🔍}
cancer, article, google, scholar, breast, pubmed, cas, statins, statin, risk, usa, study, grade, department, research, high, liao, university, data, fluvastatin, apoptosis, women, trial, effects, proliferation, clinical, prevention, med, res, metaanalysis, privacy, cookies, content, garwood, kumar, esserman, surgery, disease, access, clin, natl, trials, tamoxifen, california, san, francisco, protection, publish, search, treatment,
Topics {✒️}
month download article/chapter long-term lipid-lowering therapy preventing rho gtpase-induced dana-farber cancer institute preventing osteoporosis-related fractures gadolinium-enhanced mr imaging serum c-reactive protein clinical oncology/college randomised placebo-controlled trial large population-based setting low-density lipoprotein cholesterol 3-hydroxy-3-methylglutaryl coenzyme estrogen-receptor status full article pdf beth-ann lesnikoski elisa rush port long-term follow privacy choices/manage cookies major vascular events high grade tumors liao jk invasive breast cancer reducing tumor proliferation fluvastatin reduces proliferation low grade tumors breast cancer recurrence inducible nitric oxide 3-hydroxy-3-methylglutaryl lipophilic statin users michael campbell & laura mri tumor volume european economic area magnetic resonance images increasing apoptotic activity arginase-dependent pathways pathological prognostic factors imaging-based biomarkers biomarker modulation study conditions privacy policy breast cancer risk perioperative window trial lipid-lowering drugs case-control studies post-diagnosis statin prospective cohort study high-risk conditions high inherited risk randomized controlled trials phase ii trial accepting optional cookies
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headline:Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer
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datePublished:2009-08-29T00:00:00Z
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Statin(s)
Breast cancer
DCIS ductal carcinoma in situ
HMG-CoA reductase inhibitors
Cancer prevention
Oncology
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Statin(s)
Breast cancer
DCIS ductal carcinoma in situ
HMG-CoA reductase inhibitors
Cancer prevention
Oncology
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