
DOI . ORG {
}
Title[redir]:
Age-dependent changes in adenosine A1 receptor distribution and density within the nucleus tractus solitarii of normotensive and hypertensive rats | Journal of Neural Transmission
Description:
This study shows the distribution and density of adenosine A1 receptor (A1R) within the nucleus tractus solitarii (NTS) of Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) from birth to adulthood (1, 15, 30 and 90 days old). The NTS shows heterogeneous distribution of A1R in dorsomedial/dorsolateral, subpostremal and medial/intermediate subnuclei. A1R decrease from rostral to caudal within dorsomedial/dorsolateral subnucleus in 15-, 30- and 90-day-old WKY and SHR. A1R increase from rostral to caudal subpostremal subnucleus in 30- and 90-day-old WKY, and in 15-, 30- and 90-day-old SHR. Furthermore, A1Rs are increased in SHR as compared with WKY within dorsomedial/dorsolateral in 30- and 90-day-old and within subpostremal of 15-, 30- and 90-day-old rats. Finally, A1Rs increase from 1- to 30-day-old rats. Medial/intermediate did not show any changes in A1R from rostral to caudal levels, age or strain. In summary, our result highlights the importance of A1 adenosine system regarding the neural control of blood pressure and the development of hypertension.
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Keywords {🔍}
google, scholar, article, pubmed, adenosine, cas, rats, brain, receptor, receptors, hypertensive, nucleus, rat, res, spontaneously, tractus, pharmacol, hypertension, physiol, neural, distribution, solitarii, fiorchadi, caudal, dayold, cardiovascular, fredholm, privacy, cookies, content, journal, normotensive, carrettiero, wky, shr, access, responses, effects, stimulation, publish, search, nts, rostral, development, differential, ontogeny, brainstem, purinergic, binding, expression,
Topics {✒️}
dorsal vagal complex month download article/chapter presynaptic adenosine a1-receptors dahl salt-sensitive rats adenosine–dopamine receptor interaction nucleus tractus solitarii nucleus tractus solitarius adenosine a2a receptors adenosine a1 receptors a1 adenosine receptors full article pdf scislo tj privacy choices/manage cookies adenosine a1 receptor caudal subpostremal subnucleus marangos pj fior-chadi dr brainstem mediate hypotension neural transmission aims adenosine binding sites developing rat brain fetal rat brain a1 adenosine system adenosine uptake sites adenosine–dopamine interactions european economic area rat vagus nerve adenosine receptor ontogeny defense area stimulation scope submit manuscript long-term isolation related subjects maternal caffeine intake long-term administration ageing mouse brain heart rate development spontaneously hypertensive rats conditions privacy policy check access instant access cardiovascular excitatory effects uptake site binding adenosine receptors article journal increased adenosine bioavailability caudal levels aging wistar-kyoto caudal arteries tseng cj dopamine receptors
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headline:Age-dependent changes in adenosine A1 receptor distribution and density within the nucleus tractus solitarii of normotensive and hypertensive rats
description:This study shows the distribution and density of adenosine A1 receptor (A1R) within the nucleus tractus solitarii (NTS) of Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) from birth to adulthood (1, 15, 30 and 90 days old). The NTS shows heterogeneous distribution of A1R in dorsomedial/dorsolateral, subpostremal and medial/intermediate subnuclei. A1R decrease from rostral to caudal within dorsomedial/dorsolateral subnucleus in 15-, 30- and 90-day-old WKY and SHR. A1R increase from rostral to caudal subpostremal subnucleus in 30- and 90-day-old WKY, and in 15-, 30- and 90-day-old SHR. Furthermore, A1Rs are increased in SHR as compared with WKY within dorsomedial/dorsolateral in 30- and 90-day-old and within subpostremal of 15-, 30- and 90-day-old rats. Finally, A1Rs increase from 1- to 30-day-old rats. Medial/intermediate did not show any changes in A1R from rostral to caudal levels, age or strain. In summary, our result highlights the importance of A1 adenosine system regarding the neural control of blood pressure and the development of hypertension.
datePublished:2008-05-08T00:00:00Z
dateModified:2008-05-08T00:00:00Z
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Nucleus Tractus Solitarii
Caudal Portion
Dorsal Vagal Complex
Caudal Level
Rostral Portion
Neurology
Psychiatry
Neurosciences
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headline:Age-dependent changes in adenosine A1 receptor distribution and density within the nucleus tractus solitarii of normotensive and hypertensive rats
description:This study shows the distribution and density of adenosine A1 receptor (A1R) within the nucleus tractus solitarii (NTS) of Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) from birth to adulthood (1, 15, 30 and 90 days old). The NTS shows heterogeneous distribution of A1R in dorsomedial/dorsolateral, subpostremal and medial/intermediate subnuclei. A1R decrease from rostral to caudal within dorsomedial/dorsolateral subnucleus in 15-, 30- and 90-day-old WKY and SHR. A1R increase from rostral to caudal subpostremal subnucleus in 30- and 90-day-old WKY, and in 15-, 30- and 90-day-old SHR. Furthermore, A1Rs are increased in SHR as compared with WKY within dorsomedial/dorsolateral in 30- and 90-day-old and within subpostremal of 15-, 30- and 90-day-old rats. Finally, A1Rs increase from 1- to 30-day-old rats. Medial/intermediate did not show any changes in A1R from rostral to caudal levels, age or strain. In summary, our result highlights the importance of A1 adenosine system regarding the neural control of blood pressure and the development of hypertension.
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dateModified:2008-05-08T00:00:00Z
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Nucleus Tractus Solitarii
Caudal Portion
Dorsal Vagal Complex
Caudal Level
Rostral Portion
Neurology
Psychiatry
Neurosciences
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