We are analyzing https://link.springer.com/article/10.1007/s00702-003-0104-9.

Title:
Adenosine A1 receptor distribution in the nucleus tractus solitarii of normotensive and spontaneously hypertensive rats | Journal of Neural Transmission
Description:
Adenosine acts at many sites to modulate neuronal activity. The nucleus tractus solitarii (NTS) is a major brain site in cardiovascular control. The present study was undertaken for a detailed analysis of the distribution of A1 adenosine receptor (A1R) in the NTS of spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY), using in vitro autoradiography with [3H]DPCPX. The density of [3H]DPCPX in the whole NTS decreased according to the rostral-caudal levels. This high level of [3H]DPCPX binding at rostral sites is due to an specific label of the dorsomedial/dorsolateral subnuclei. On the other hand, analysis of subpostremal subnucleus, showed opposite results. The density of [3H]DPCPX binding in the subpostremal NTS increased according to the rostral-caudal levels. Furthermore, it was observed an increased [3H]DPCPX binding in the SHR compared with WKY. The results show a complex pattern of A1R distribution in the NTS, which highlight the powerful modulatory actions mediated by adenosine in the NTS barosensitive neurons.
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Keywords {🔍}

article, adenosine, nts, receptors, privacy, cookies, content, journal, distribution, hdpcpx, access, publish, search, receptor, nucleus, tractus, solitarii, spontaneously, hypertensive, rats, analysis, data, information, log, research, neural, transmission, carrettiero, fiorchadi, binding, increased, discover, springer, site, optional, personal, parties, policy, find, track, normotensive, published, february, cite, explore, sites, shr, wky, density, rostralcaudal,

Topics {✒️}

month download article/chapter equilibrative nucleoside transporters increased [3h]dpcpx binding a1 adenosine receptor neural transmission aims privacy choices/manage cookies fior-chadi rights adenosine receptors spontaneously hypertensive rats full article pdf hippocampal synaptic transmission related subjects increased adenosine bioavailability european economic area nucleus tractus solitarii scope submit manuscript modulate neuronal activity dorsomedial/dorsolateral subnuclei 1007/s00702-003-0104-9 keywords [3h]dpcpx binding conditions privacy policy rostral-caudal levels showed opposite results accepting optional cookies major brain site nts barosensitive neurons journal finder publish subpostremal nts increased article journal fior-chadi article log check access neural transm 111 instant access privacy policy personal data [3h]dpcpx adenosinergic system article cite books a adenosine acts article carrettiero differential distribution optional cookies manage preferences katp channels journal publish subscription content similar content a1r distribution

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         description:Adenosine acts at many sites to modulate neuronal activity. The nucleus tractus solitarii (NTS) is a major brain site in cardiovascular control. The present study was undertaken for a detailed analysis of the distribution of A1 adenosine receptor (A1R) in the NTS of spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY), using in vitro autoradiography with [3H]DPCPX. The density of [3H]DPCPX in the whole NTS decreased according to the rostral-caudal levels. This high level of [3H]DPCPX binding at rostral sites is due to an specific label of the dorsomedial/dorsolateral subnuclei. On the other hand, analysis of subpostremal subnucleus, showed opposite results. The density of [3H]DPCPX binding in the subpostremal NTS increased according to the rostral-caudal levels. Furthermore, it was observed an increased [3H]DPCPX binding in the SHR compared with WKY. The results show a complex pattern of A1R distribution in the NTS, which highlight the powerful modulatory actions mediated by adenosine in the NTS barosensitive neurons.
         datePublished:2004-02-04T00:00:00Z
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