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We began analyzing https://link.springer.com/article/10.1007/s00424-003-1018-y, but it redirected us to https://link.springer.com/article/10.1007/s00424-003-1018-y. The analysis below is for the second page.

Title[redir]:
Ion selectivity of stretch-activated cation currents in mouse ventricular myocytes | Pflügers Archiv - European Journal of Physiology
Description:
Stretch-activated non-selective cation currents (I SAC) constitute a mechanism that can induce cardiac arrhythmias. We studied I SAC in mouse ventricular myocytes by stretching part of the cell surface between the patch-pipette and a motor-driven glass stylus. In non-clamped cells, local stretch depolarised and induced after-depolarisations and extrasystoles. In voltage-clamped cells (K+ currents suppressed) I SAC activated by local stretch had a nearly linear voltage dependence and reversed polarity between −12 and 0 mV. Conductance G SAC increased with the extent of local stretch. I SAC was not a Cl− current (insensitivity to replacement of Cl− by aspartate−). I SAC was not a Ca2+-activated current (insensitivity to 5 mM intracellular BAPTA). G SAC was blocked by 5 µM GdCl3 or by 75 mM extracellular (e.c.) CaCl2. Removal of e.c. CaCl2 increased G SAC 2.5-fold, as if G SAC were sensitive to Ca2+ and Gd3+. Replacement of 150 mM e.c. Na+ by 150 mM Cs+, Li+, tetraethylammonium (TEA+) or N-methyl d-glucosamine (NMDG+) yielded currents that suggested for the conductance a selectivity G Cs>G Na>G Li>G TEA>G NMDG. I SAC was suppressed by cytochalasin D, as if an intact F-actin cytoskeleton were necessary for activation of I SAC.

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Keywords {🔍}

google, scholar, cas, pubmed, article, ventricular, channels, ion, currents, myocytes, sac, stretchactivated, isenberg, cell, calcium, res, sachs, physiol, cardiovasc, kamkin, kiseleva, cardiac, stretch, access, heart, biol, privacy, cookies, content, cation, cells, publish, search, selectivity, current, isolated, mol, guineapig, pflugers, arch, lab, mechanoelectric, feedback, data, information, log, journal, research, mouse, gerrit,

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stretch-activated ion channels month download article/chapter selective cation channel mechanosensitive ion channels stretch-activated cation currents n-methyl d-glucosamine adult guinea-pig hearts guinea-pig urinary bladder large stretch-induced increase motor-driven glass stylus guinea-pig ventricular myocytes intact f-actin cytoskeleton na-ca exchange current ion selectivity selective cation currents ca2+-activated current full article pdf mechanically induced fluxes privacy choices/manage cookies mouse ventricular myocytes stretch-activated currents stretch activated currents ventricular cells isolated left ventricular infarction mechanically activated currents calcium-activated local stretch depolarised block article kamkin european economic area rna reads encoding related subjects action potential characteristics le guennec jy ter keurs hedj interactive computer model max-planck-award cardiac conduction system cardiac action potential conditions privacy policy check access instant access calcium currents linear voltage dependence mechano-electric feedback chronic atrial fibrillation programmed cell survival induce cardiac arrhythmias cellular electrophysiological effects arrhythmogenic effects increase

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