We are analyzing https://link.springer.com/article/10.1007/s002320001023.

Title:
Activation and Inactivation of Mechanosensitive Currents in the Chick Heart | The Journal of Membrane Biology
Description:
The behavior of MS channels in embryonic chick ventricular myocytes activated by direct mechanical stimulation is strongly affected by inactivation. The amplitude of the current is dependent not only on the amplitude of the stimulus, but also the history of stimulation. The MS current inactivation appears to be composed of at least two contributions: (i) rearrangement of the cortical tension transducing elements and (ii) blocking action of an autocrine agent released from the cell. With discrete mechanical stimuli, the MS current amplitude in the second press of a double press protocol was always smaller than the amplitude of the first MS current. Occasionally, a large MS current occurred when the cell was first stimulated, but subsequently the cell became unresponsive. For a series of stimuli of varying amplitudes, the order in which they were applied to the cell affected the size of the observed MS current for a given stimulus magnitude. When continuous sinusoidal stimulation was applied to the cells, the MS current envelope either reached a steady state, or inactivated. With sinusoidal stimulation, the MS response could be enhanced or restored by simple perfusion of fluid across the cell. This suggests that mechanical stimulation of the cells produces an autocrine inhibitor of MS channels as well as resulting in cortical rearrangement.
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Keywords {🔍}

article, current, cell, access, privacy, cookies, content, journal, stimulation, information, publish, search, inactivation, amplitude, data, log, research, membrane, activation, chick, bett, sachs, mechanical, cells, open, discover, springer, optional, personal, parties, varying, policy, find, track, biology, mechanosensitive, currents, heart, cite, gcl, explore, channels, affected, stimulus, rearrangement, cortical, autocrine, stimuli, press, applied,

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month download article/chapter related subjects privacy choices/manage cookies full article pdf ms response membrane biology aims european economic area scope submit manuscript improve clinical outcomes chick heart published conditions privacy policy observed ms current ms current envelope autocrine agent released accepting optional cookies double press protocol check access instant access direct mechanical stimulation continuous sinusoidal stimulation discrete mechanical stimuli main content log ms current amplitude cell affected journal finder publish article log activation article cite steady state article bett chick heart privacy policy personal data ms current books a optional cookies information manage preferences cells produces membrane biol cell mechanical stimulation ms channels sinusoidal stimulation article data protection essential cookies cookies skip subscription content similar content

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         headline:Activation and Inactivation of Mechanosensitive Currents in the Chick Heart
         description: The behavior of MS channels in embryonic chick ventricular myocytes activated by direct mechanical stimulation is strongly affected by inactivation. The amplitude of the current is dependent not only on the amplitude of the stimulus, but also the history of stimulation. The MS current inactivation appears to be composed of at least two contributions: (i) rearrangement of the cortical tension transducing elements and (ii) blocking action of an autocrine agent released from the cell. With discrete mechanical stimuli, the MS current amplitude in the second press of a double press protocol was always smaller than the amplitude of the first MS current. Occasionally, a large MS current occurred when the cell was first stimulated, but subsequently the cell became unresponsive. For a series of stimuli of varying amplitudes, the order in which they were applied to the cell affected the size of the observed MS current for a given stimulus magnitude. When continuous sinusoidal stimulation was applied to the cells, the MS current envelope either reached a steady state, or inactivated. With sinusoidal stimulation, the MS response could be enhanced or restored by simple perfusion of fluid across the cell. This suggests that mechanical stimulation of the cells produces an autocrine inhibitor of MS channels as well as resulting in cortical rearrangement.
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      headline:Activation and Inactivation of Mechanosensitive Currents in the Chick Heart
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      pageEnd:254
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         general
         Human Physiology
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