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pubmed, article, study, rsg, google, scholar, disease, research, dementia, university, brain, cas, plcg, risk, diseases, association, department, longevity, central, analysis, alzheimers, effect, patients, amsterdam, center, variant, age, genetic, years, controls, studies, health, neurodegenerative, supported, van, foundation, consortium, netherlands, resource, institute, biobank, protective, neurology, data, dlb, online, clinic, germany, alzheimer, immune,

Topics {✒️}

inverse-variance fixed-effect meta-analyses inverse-variance fixed-effect meta-analysis international parkinson disease genomics consortium α-synuclein-positive lewy bodies javier simon-sanchez genome-wide association meta-analysis monica diez-fairen cool-temperature-mediated activation oriol dols-icardo r-package ‘rmeta’ v3 la recerca biomedica eloy rodríguez rodríguez article download pdf maria carolina dalmasso mercè boada agonist-induced ca2+ entry international ftd-genomics consortium apoe isoform-specific disruption genome-wide association study global cognitive functioning/mmse genome-wide association studies amyotrophic lateral sclerosis visuo-spatial tests compared open access resource neocortical lewy-related pathology immune-related genetic enrichment agustín ruiz pascual sánchez-juan case-control association mapping carlos iii institute existing gwas meta-analyses higher expression levels dutch case-control samples disease phospholipase c-gamma-2 logistic regression models generalitat de catalunya protein-coding genetic variation �sant pau initiative german research network van der lee kompetenznetz multiple sklerose innovation-oriented research program genome-wide association medical systems biology itziar de rojas community-based cohort study plcg2-related immune signaling sant pau hospital henne holstege fermin moreno

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         headline:A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
         description:The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target.
         datePublished:2019-05-26T00:00:00Z
         dateModified:2020-01-18T00:00:00Z
         pageStart:237
         pageEnd:250
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s00401-019-02026-8
         keywords:
            Alzheimer’s disease
            Frontotemporal dementia
            Dementia with Lewy bodies
            Progressive supranuclear palsy
            Parkinson’s disease
            Amyotrophic lateral sclerosis
            Multiple sclerosis
            Neurodegenerative disease
            Longevity
            PLCG2
            Phospholipase C Gamma 2
            Pathology
            Neurosciences
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            name:Acta Neuropathologica
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               1432-0533
               0001-6322
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                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Niccolo Tesi
               url:http://orcid.org/0000-0002-1413-5091
               affiliation:
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Delft University of Technology
                     address:
                        name:Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christopher M. Morris
               affiliation:
                     name:Newcastle University
                     address:
                        name:Newcastle Brain Tissue Resource, Edwardson Building, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Begoña Indakoetxea
               affiliation:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                     address:
                        name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                        type:PostalAddress
                     type:Organization
                     name:Instituto Biodonostia
                     address:
                        name:Instituto Biodonostia, San Sebastian, Spain
                        type:PostalAddress
                     type:Organization
                     name:Hospital Universitario San Sebastian
                     address:
                        name:Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lyduine E. Collij
               affiliation:
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Martin Scherer
               affiliation:
                     name:University Medical Center
                     address:
                        name:Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Estrella Morenas-Rodríguez
               affiliation:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                     address:
                        name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                        type:PostalAddress
                     type:Organization
                     name:Universitat Autonoma de Barcelona
                     address:
                        name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:James W. Ironside
               affiliation:
                     name:University of Edinburgh
                     address:
                        name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bart N. M. van Berckel
               affiliation:
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniel Alcolea
               affiliation:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                     address:
                        name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                        type:PostalAddress
                     type:Organization
                     name:Universitat Autonoma de Barcelona
                     address:
                        name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Heinz Wiendl
               affiliation:
                     name:German Competence Network Multiple Sclerosis (KKNMS)
                     address:
                        name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Münster
                     address:
                        name:Department of Neurology, Klinik für Neurologie mit Institut für Translationale Neurologie, University of Münster, Münster, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Samantha L. Strickland
               affiliation:
                     name:Mayo Clinic Florida
                     address:
                        name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pau Pastor
               affiliation:
                     name:University Hospital Mutua de Terrassa
                     address:
                        name:Movement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
                     name:Fundacio per la Recerca Biomedica I Social Mutua Terrassa
                     address:
                        name:Fundacio per la Recerca Biomedica I Social Mutua Terrassa, Terrassa, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eloy Rodríguez Rodríguez
               affiliation:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                     address:
                        name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                        type:PostalAddress
                     type:Organization
                     name:University Hospital “Marques de Valdecilla”
                     address:
                        name:University Hospital “Marques de Valdecilla”, Santander, Spain
                        type:PostalAddress
                     type:Organization
                     name:IDIVAL
                     address:
                        name:IDIVAL, Santander, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bradley F. Boeve
               affiliation:
                     name:Mayo Clinic Minnesota
                     address:
                        name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ronald C. Petersen
               affiliation:
                     name:Mayo Clinic Minnesota
                     address:
                        name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tanis J. Ferman
               affiliation:
                     name:Mayo Clinic Florida
                     address:
                        name:Department of Psychiatry and Psychology, Mayo Clinic Florida, Jacksonville, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jay A. van Gerpen
               affiliation:
                     name:Mayo Clinic Florida
                     address:
                        name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marcel J. T. Reinders
               affiliation:
                     name:Delft University of Technology
                     address:
                        name:Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ryan J. Uitti
               affiliation:
                     name:Mayo Clinic Florida
                     address:
                        name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lluís Tárraga
               affiliation:
                     name:Universitat Internacional de Catalunya
                     address:
                        name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                     address:
                        name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wolfgang Maier
               affiliation:
                     name:University of Bonn
                     address:
                        name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
                        type:PostalAddress
                     type:Organization
                     name:DZNE, German Center for Neurodegenerative Diseases
                     address:
                        name:DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Oriol Dols-Icardo
               affiliation:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                     address:
                        name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                        type:PostalAddress
                     type:Organization
                     name:Universitat Autonoma de Barcelona
                     address:
                        name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Amit Kawalia
               affiliation:
                     name:University Hospital Cologne
                     address:
                        name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Maria Carolina Dalmasso
               affiliation:
                     name:University Hospital Cologne
                     address:
                        name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
                        type:PostalAddress
                     type:Organization
                     name:Fundación Instituto Leloir-IIBBA-CONICET
                     address:
                        name:Fundación Instituto Leloir-IIBBA-CONICET, Buenos Aires, Argentina
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mercè Boada
               affiliation:
                     name:Universitat Internacional de Catalunya
                     address:
                        name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                     address:
                        name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Uwe K. Zettl
               affiliation:
                     name:German Competence Network Multiple Sclerosis (KKNMS)
                     address:
                        name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Rostock
                     address:
                        name:Department of Neurology, University of Rostock, Rostock, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Natasja M. van Schoor
               affiliation:
                     name:Amsterdam Public Health Research Institute
                     address:
                        name:Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marian Beekman
               affiliation:
                     name:Leiden University Medical Center
                     address:
                        name:Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mariet Allen
               affiliation:
                     name:Mayo Clinic Florida
                     address:
                        name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eliezer Masliah
               affiliation:
                     name:National Institute on Aging, National Institutes of Health
                     address:
                        name:Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Adolfo López de Munain
               affiliation:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                     address:
                        name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                        type:PostalAddress
                     type:Organization
                     name:Instituto Biodonostia
                     address:
                        name:Instituto Biodonostia, San Sebastian, Spain
                        type:PostalAddress
                     type:Organization
                     name:Hospital Universitario San Sebastian
                     address:
                        name:Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alexander Pantelyat
               affiliation:
                     name:Johns Hopkins University Medical Center
                     address:
                        name:Department of Neurology, Johns Hopkins University Medical Center, Baltimore, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zbigniew K. Wszolek
               affiliation:
                     name:Mayo Clinic Florida
                     address:
                        name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Owen A. Ross
               affiliation:
                     name:Mayo Clinic Florida
                     address:
                        name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dennis W. Dickson
               affiliation:
                     name:Mayo Clinic Florida
                     address:
                        name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Neill R. Graff-Radford
               affiliation:
                     name:Mayo Clinic Florida
                     address:
                        name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:David Knopman
               affiliation:
                     name:Mayo Clinic Minnesota
                     address:
                        name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rosa Rademakers
               affiliation:
                     name:Mayo Clinic Florida
                     address:
                        name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Afina W. Lemstra
               affiliation:
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yolande A. L. Pijnenburg
               affiliation:
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Philip Scheltens
               url:http://orcid.org/0000-0002-1046-6408
               affiliation:
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thomas Gasser
               affiliation:
                     name:University of Tuebingen
                     address:
                        name:Center of Neurology, Department of Neurodegenerative diseases, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Patrick F Chinnery
               affiliation:
                     name:University of Cambridge
                     address:
                        name:Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge
                     address:
                        name:MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bernhard Hemmer
               affiliation:
                     name:Technical University of Munich
                     address:
                        name:Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Competence Network Multiple Sclerosis (KKNMS)
                     address:
                        name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
                        type:PostalAddress
                     type:Organization
                     name:Munich Cluster for Systems Neurology (SyNergy)
                     address:
                        name:Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Martijn A. Huisman
               affiliation:
                     name:Amsterdam Public Health Research Institute
                     address:
                        name:Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:VU University
                     address:
                        name:Department of Sociology, VU University, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Juan Troncoso
               affiliation:
                     name:Johns Hopkins University Medical Center
                     address:
                        name:Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Fermin Moreno
               affiliation:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                     address:
                        name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                        type:PostalAddress
                     type:Organization
                     name:Instituto Biodonostia
                     address:
                        name:Instituto Biodonostia, San Sebastian, Spain
                        type:PostalAddress
                     type:Organization
                     name:Hospital Universitario San Sebastian
                     address:
                        name:Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ellen A. Nohr
               affiliation:
                     name:University of Southern Denmark
                     address:
                        name:Research Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thorkild I. A. Sørensen
               affiliation:
                     name:Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics
                     address:
                        name:Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Copenhagen, Denmark
                        type:PostalAddress
                     type:Organization
                     name:University of Copenhagen
                     address:
                        name:Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
                        type:PostalAddress
                     type:Organization
                     name:Bristol University
                     address:
                        name:MRC Integrative Epidemiology Unit, Bristol University, Bristol, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Peter Heutink
               affiliation:
                     name:German Center for Neurodegenerative Diseases (DZNE)-Tübingen
                     address:
                        name:German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Tübingen
                     address:
                        name:Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pascual Sánchez-Juan
               affiliation:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                     address:
                        name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                        type:PostalAddress
                     type:Organization
                     name:University Hospital “Marques de Valdecilla”
                     address:
                        name:University Hospital “Marques de Valdecilla”, Santander, Spain
                        type:PostalAddress
                     type:Organization
                     name:IDIVAL
                     address:
                        name:IDIVAL, Santander, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Danielle Posthuma
               affiliation:
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jordi Clarimón
               affiliation:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                     address:
                        name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                        type:PostalAddress
                     type:Organization
                     name:Universitat Autonoma de Barcelona
                     address:
                        name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kaare Christensen
               affiliation:
                     name:University of Southern Denmark
                     address:
                        name:The Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
                        type:PostalAddress
                     type:Organization
                     name:Odense University Hospital
                     address:
                        name:Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
                        type:PostalAddress
                     type:Organization
                     name:Odense University Hospital
                     address:
                        name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
                        type:PostalAddress
                     type:Organization
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               name:Nilüfer Ertekin-Taner
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                     name:Mayo Clinic Florida
                     address:
                        name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
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                     name:National Institute of Neurological Disorders and Stroke
                     address:
                        name:Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, USA
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                     type:Organization
                     name:Johns Hopkins University Medical Center
                     address:
                        name:Department of Neurology, Johns Hopkins University Medical Center, Baltimore, USA
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                     type:Organization
               type:Person
               name:Alfredo Ramirez
               affiliation:
                     name:University of Bonn
                     address:
                        name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
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                     name:University Hospital Cologne
                     address:
                        name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
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               name:Agustín Ruiz
               affiliation:
                     name:Universitat Internacional de Catalunya
                     address:
                        name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
                        type:PostalAddress
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               name:Eline Slagboom
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                     name:Leiden University Medical Center
                     address:
                        name:Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
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                     address:
                        name:Dutch Society for Research on Ageing, Leiden, The Netherlands
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               name:Wiesje M. van der Flier
               affiliation:
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
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               name:Henne Holstege
               url:http://orcid.org/0000-0002-7688-3087
               affiliation:
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Vrije Universiteit Amsterdam, Amsterdam UMC
                     address:
                        name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
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               email:[email protected]
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         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
      description:The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target.
      datePublished:2019-05-26T00:00:00Z
      dateModified:2020-01-18T00:00:00Z
      pageStart:237
      pageEnd:250
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00401-019-02026-8
      keywords:
         Alzheimer’s disease
         Frontotemporal dementia
         Dementia with Lewy bodies
         Progressive supranuclear palsy
         Parkinson’s disease
         Amyotrophic lateral sclerosis
         Multiple sclerosis
         Neurodegenerative disease
         Longevity
         PLCG2
         Phospholipase C Gamma 2
         Pathology
         Neurosciences
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00401-019-02026-8/MediaObjects/401_2019_2026_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00401-019-02026-8/MediaObjects/401_2019_2026_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00401-019-02026-8/MediaObjects/401_2019_2026_Fig3_HTML.jpg
      isPartOf:
         name:Acta Neuropathologica
         issn:
            1432-0533
            0001-6322
         volumeNumber:138
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Sven J. van der Lee
            url:http://orcid.org/0000-0003-1606-8643
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
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                  type:Organization
            email:[email protected]
            type:Person
            name:Olivia J. Conway
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                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
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            name:Iris Jansen
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
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            name:Minerva M. Carrasquillo
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                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
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            name:Luca Kleineidam
            affiliation:
                  name:University of Bonn
                  address:
                     name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
                     type:PostalAddress
                  type:Organization
                  name:DZNE, German Center for Neurodegenerative Diseases
                  address:
                     name:DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany
                     type:PostalAddress
                  type:Organization
                  name:University Hospital Cologne
                  address:
                     name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
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                  type:Organization
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            name:Erik van den Akker
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                  name:Leiden University Medical Center
                  address:
                     name:Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Delft University of Technology
                  address:
                     name:Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Isabel Hernández
            affiliation:
                  name:Universitat Internacional de Catalunya
                  address:
                     name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
                     type:PostalAddress
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            name:Kristel R. van Eijk
            affiliation:
                  name:University Medical Center Utrecht
                  address:
                     name:Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
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            type:Person
            name:Najada Stringa
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                  address:
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                  type:Organization
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            name:Jason A. Chen
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                  name:University of California
                  address:
                     name:Interdepartmental Program in Bioinformatics, University of California, Los Angeles, USA
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            type:Person
            name:Anna Zettergren
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                  name:Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg
                  address:
                     name:Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden
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                     name:Max Planck Institute of Psychiatry, Munich, Germany
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                  type:Organization
                  name:Technical University of Munich
                  address:
                     name:Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
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                  name:German Competence Network Multiple Sclerosis (KKNMS)
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                     name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
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            name:Monica Diez-Fairen
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                  name:University Hospital Mutua de Terrassa
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                  name:Fundacio per la Recerca Biomedica I Social Mutua Terrassa
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            name:Javier Simon-Sanchez
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                     name:German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany
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                  name:University of Tübingen
                  address:
                     name:Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
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            type:Person
            name:Alberto Lleó
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                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
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                  type:Organization
                  name:Universitat Autonoma de Barcelona
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                     name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
                     type:PostalAddress
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            name:Henrik Zetterberg
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                  name:Sahlgrenska University Hospital
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                  name:Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg
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                     name:Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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                  type:Organization
                  name:UCL Institute of Neurology, Queen Square
                  address:
                     name:Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK
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            name:Marianne Nygaard
            affiliation:
                  name:University of Southern Denmark
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                  type:Organization
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            name:Cornelis Blauwendraat
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                  name:National Institute of Neurological Disorders and Stroke
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            name:Jeanne E. Savage
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
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            name:Jonas Mengel-From
            affiliation:
                  name:University of Southern Denmark
                  address:
                     name:Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sonia Moreno-Grau
            affiliation:
                  name:Universitat Internacional de Catalunya
                  address:
                     name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael Wagner
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                  name:University of Bonn
                  address:
                     name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
                     type:PostalAddress
                  type:Organization
                  name:DZNE, German Center for Neurodegenerative Diseases
                  address:
                     name:DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany
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            name:Juan Fortea
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                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
                  name:Universitat Autonoma de Barcelona
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                     name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
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            name:Michael J. Keogh
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                  type:Organization
                  name:University of Cambridge
                  address:
                     name:Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
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            type:Person
            name:Kaj Blennow
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                  name:Sahlgrenska University Hospital
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                     name:Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
                     type:PostalAddress
                  type:Organization
                  name:Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg
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                     name:Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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            name:Ingmar Skoog
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                  name:Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg
                  address:
                     name:Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden
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            name:Manuel A. Friese
            affiliation:
                  name:German Competence Network Multiple Sclerosis (KKNMS)
                  address:
                     name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:Universitätsklinikum Hamburg‐Eppendorf
                  address:
                     name:Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg‐Eppendorf, Hamburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Olga Pletnikova
            affiliation:
                  name:Johns Hopkins University Medical Center
                  address:
                     name:Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Miren Zulaica
            affiliation:
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
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                     name:Instituto Biodonostia, San Sebastian, Spain
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            name:Carmen Lage
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                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
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                  name:University Hospital “Marques de Valdecilla”
                  address:
                     name:University Hospital “Marques de Valdecilla”, Santander, Spain
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                  name:IDIVAL
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                     name:IDIVAL, Santander, Spain
                     type:PostalAddress
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            name:Itziar de Rojas
            affiliation:
                  name:Universitat Internacional de Catalunya
                  address:
                     name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Steffi Riedel-Heller
            affiliation:
                  name:University of Leipzig
                  address:
                     name:Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ignacio Illán-Gala
            affiliation:
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
                  name:Universitat Autonoma de Barcelona
                  address:
                     name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wei Wei
            affiliation:
                  name:University of Cambridge
                  address:
                     name:Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bernard Jeune
            affiliation:
                  name:University of Southern Denmark
                  address:
                     name:Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Adelina Orellana
            affiliation:
                  name:Universitat Internacional de Catalunya
                  address:
                     name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Florian Then Bergh
            affiliation:
                  name:German Competence Network Multiple Sclerosis (KKNMS)
                  address:
                     name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Leipzig
                  address:
                     name:Department of Neurology, University of Leipzig, Leipzig, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xue Wang
            affiliation:
                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marc Hulsman
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Delft University of Technology
                  address:
                     name:Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nina Beker
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Niccolo Tesi
            url:http://orcid.org/0000-0002-1413-5091
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Delft University of Technology
                  address:
                     name:Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christopher M. Morris
            affiliation:
                  name:Newcastle University
                  address:
                     name:Newcastle Brain Tissue Resource, Edwardson Building, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Begoña Indakoetxea
            affiliation:
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
                  name:Instituto Biodonostia
                  address:
                     name:Instituto Biodonostia, San Sebastian, Spain
                     type:PostalAddress
                  type:Organization
                  name:Hospital Universitario San Sebastian
                  address:
                     name:Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lyduine E. Collij
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Martin Scherer
            affiliation:
                  name:University Medical Center
                  address:
                     name:Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Estrella Morenas-Rodríguez
            affiliation:
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
                  name:Universitat Autonoma de Barcelona
                  address:
                     name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:James W. Ironside
            affiliation:
                  name:University of Edinburgh
                  address:
                     name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bart N. M. van Berckel
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel Alcolea
            affiliation:
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
                  name:Universitat Autonoma de Barcelona
                  address:
                     name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Heinz Wiendl
            affiliation:
                  name:German Competence Network Multiple Sclerosis (KKNMS)
                  address:
                     name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Münster
                  address:
                     name:Department of Neurology, Klinik für Neurologie mit Institut für Translationale Neurologie, University of Münster, Münster, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Samantha L. Strickland
            affiliation:
                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pau Pastor
            affiliation:
                  name:University Hospital Mutua de Terrassa
                  address:
                     name:Movement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Fundacio per la Recerca Biomedica I Social Mutua Terrassa
                  address:
                     name:Fundacio per la Recerca Biomedica I Social Mutua Terrassa, Terrassa, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eloy Rodríguez Rodríguez
            affiliation:
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
                  name:University Hospital “Marques de Valdecilla”
                  address:
                     name:University Hospital “Marques de Valdecilla”, Santander, Spain
                     type:PostalAddress
                  type:Organization
                  name:IDIVAL
                  address:
                     name:IDIVAL, Santander, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bradley F. Boeve
            affiliation:
                  name:Mayo Clinic Minnesota
                  address:
                     name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ronald C. Petersen
            affiliation:
                  name:Mayo Clinic Minnesota
                  address:
                     name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tanis J. Ferman
            affiliation:
                  name:Mayo Clinic Florida
                  address:
                     name:Department of Psychiatry and Psychology, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jay A. van Gerpen
            affiliation:
                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marcel J. T. Reinders
            affiliation:
                  name:Delft University of Technology
                  address:
                     name:Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ryan J. Uitti
            affiliation:
                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lluís Tárraga
            affiliation:
                  name:Universitat Internacional de Catalunya
                  address:
                     name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wolfgang Maier
            affiliation:
                  name:University of Bonn
                  address:
                     name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
                     type:PostalAddress
                  type:Organization
                  name:DZNE, German Center for Neurodegenerative Diseases
                  address:
                     name:DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Oriol Dols-Icardo
            affiliation:
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
                  name:Universitat Autonoma de Barcelona
                  address:
                     name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Amit Kawalia
            affiliation:
                  name:University Hospital Cologne
                  address:
                     name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maria Carolina Dalmasso
            affiliation:
                  name:University Hospital Cologne
                  address:
                     name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
                     type:PostalAddress
                  type:Organization
                  name:Fundación Instituto Leloir-IIBBA-CONICET
                  address:
                     name:Fundación Instituto Leloir-IIBBA-CONICET, Buenos Aires, Argentina
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mercè Boada
            affiliation:
                  name:Universitat Internacional de Catalunya
                  address:
                     name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Uwe K. Zettl
            affiliation:
                  name:German Competence Network Multiple Sclerosis (KKNMS)
                  address:
                     name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Rostock
                  address:
                     name:Department of Neurology, University of Rostock, Rostock, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Natasja M. van Schoor
            affiliation:
                  name:Amsterdam Public Health Research Institute
                  address:
                     name:Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marian Beekman
            affiliation:
                  name:Leiden University Medical Center
                  address:
                     name:Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mariet Allen
            affiliation:
                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eliezer Masliah
            affiliation:
                  name:National Institute on Aging, National Institutes of Health
                  address:
                     name:Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Adolfo López de Munain
            affiliation:
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
                  name:Instituto Biodonostia
                  address:
                     name:Instituto Biodonostia, San Sebastian, Spain
                     type:PostalAddress
                  type:Organization
                  name:Hospital Universitario San Sebastian
                  address:
                     name:Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alexander Pantelyat
            affiliation:
                  name:Johns Hopkins University Medical Center
                  address:
                     name:Department of Neurology, Johns Hopkins University Medical Center, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zbigniew K. Wszolek
            affiliation:
                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Owen A. Ross
            affiliation:
                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dennis W. Dickson
            affiliation:
                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Neill R. Graff-Radford
            affiliation:
                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David Knopman
            affiliation:
                  name:Mayo Clinic Minnesota
                  address:
                     name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rosa Rademakers
            affiliation:
                  name:Mayo Clinic Florida
                  address:
                     name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Afina W. Lemstra
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yolande A. L. Pijnenburg
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Philip Scheltens
            url:http://orcid.org/0000-0002-1046-6408
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thomas Gasser
            affiliation:
                  name:University of Tuebingen
                  address:
                     name:Center of Neurology, Department of Neurodegenerative diseases, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Patrick F Chinnery
            affiliation:
                  name:University of Cambridge
                  address:
                     name:Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge
                  address:
                     name:MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bernhard Hemmer
            affiliation:
                  name:Technical University of Munich
                  address:
                     name:Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Competence Network Multiple Sclerosis (KKNMS)
                  address:
                     name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:Munich Cluster for Systems Neurology (SyNergy)
                  address:
                     name:Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Martijn A. Huisman
            affiliation:
                  name:Amsterdam Public Health Research Institute
                  address:
                     name:Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:VU University
                  address:
                     name:Department of Sociology, VU University, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Juan Troncoso
            affiliation:
                  name:Johns Hopkins University Medical Center
                  address:
                     name:Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fermin Moreno
            affiliation:
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
                  name:Instituto Biodonostia
                  address:
                     name:Instituto Biodonostia, San Sebastian, Spain
                     type:PostalAddress
                  type:Organization
                  name:Hospital Universitario San Sebastian
                  address:
                     name:Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ellen A. Nohr
            affiliation:
                  name:University of Southern Denmark
                  address:
                     name:Research Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thorkild I. A. Sørensen
            affiliation:
                  name:Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics
                  address:
                     name:Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Copenhagen, Denmark
                     type:PostalAddress
                  type:Organization
                  name:University of Copenhagen
                  address:
                     name:Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Bristol University
                  address:
                     name:MRC Integrative Epidemiology Unit, Bristol University, Bristol, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Peter Heutink
            affiliation:
                  name:German Center for Neurodegenerative Diseases (DZNE)-Tübingen
                  address:
                     name:German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Tübingen
                  address:
                     name:Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pascual Sánchez-Juan
            affiliation:
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
                  name:University Hospital “Marques de Valdecilla”
                  address:
                     name:University Hospital “Marques de Valdecilla”, Santander, Spain
                     type:PostalAddress
                  type:Organization
                  name:IDIVAL
                  address:
                     name:IDIVAL, Santander, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Danielle Posthuma
            affiliation:
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Vrije Universiteit Amsterdam, Amsterdam UMC
                  address:
                     name:Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jordi Clarimón
            affiliation:
                  name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
                  address:
                     name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
                     type:PostalAddress
                  type:Organization
                  name:Universitat Autonoma de Barcelona
                  address:
                     name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kaare Christensen
            affiliation:
                  name:University of Southern Denmark
                  address:
                     name:The Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Odense University Hospital
                  address:
                     name:Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
                     type:PostalAddress
                  type:Organization
                  name:Odense University Hospital
                  address:
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                  address:
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            name:Alfredo Ramirez
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            name:Henne Holstege
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["Periodical","PublicationVolume"]:
      name:Acta Neuropathologica
      issn:
         1432-0533
         0001-6322
      volumeNumber:138
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      name:Springer Berlin Heidelberg
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      name:University of Bonn
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      name:Delft University of Technology
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         name:Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands
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      name:Universitat Internacional de Catalunya
      address:
         name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
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      name:University Medical Center Utrecht
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      name:University of California
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         name:Interdepartmental Program in Bioinformatics, University of California, Los Angeles, USA
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      name:Max Planck Institute of Psychiatry
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      name:Technical University of Munich
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         name:Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
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      name:German Competence Network Multiple Sclerosis (KKNMS)
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      name:German Center for Neurodegenerative Diseases (DZNE)-Tübingen
      address:
         name:German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany
         type:PostalAddress
      name:University of Tübingen
      address:
         name:Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
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      address:
         name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
         type:PostalAddress
      name:Universitat Autonoma de Barcelona
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         type:PostalAddress
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      name:UCL Institute of Neurology, Queen Square
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      name:National Institute of Neurological Disorders and Stroke
      address:
         name:Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, USA
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      name:Vrije Universiteit Amsterdam, Amsterdam UMC
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         type:PostalAddress
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      address:
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         type:PostalAddress
      name:Universitat Internacional de Catalunya
      address:
         name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
         type:PostalAddress
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      address:
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         type:PostalAddress
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         type:PostalAddress
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         type:PostalAddress
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      address:
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         type:PostalAddress
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         type:PostalAddress
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      name:Universitat Internacional de Catalunya
      address:
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         type:PostalAddress
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      name:University of Leipzig
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         type:PostalAddress
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         name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
         type:PostalAddress
      name:Vrije Universiteit Amsterdam, Amsterdam UMC
      address:
         name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
         type:PostalAddress
      name:Vrije Universiteit Amsterdam, Amsterdam UMC
      address:
         name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
         type:PostalAddress
      name:Delft University of Technology
      address:
         name:Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands
         type:PostalAddress
      name:Vrije Universiteit Amsterdam, Amsterdam UMC
      address:
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         type:PostalAddress
      name:Vrije Universiteit Amsterdam, Amsterdam UMC
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         type:PostalAddress
      name:Vrije Universiteit Amsterdam, Amsterdam UMC
      address:
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         type:PostalAddress
      name:Delft University of Technology
      address:
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         type:PostalAddress
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      address:
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         type:PostalAddress
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      address:
         name:Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
         type:PostalAddress
      name:University Medical Center
      address:
         name:Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, Germany
         type:PostalAddress
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      address:
         name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
         type:PostalAddress
      name:Universitat Autonoma de Barcelona
      address:
         name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
         type:PostalAddress
      name:University of Edinburgh
      address:
         name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
         type:PostalAddress
      name:Vrije Universiteit Amsterdam, Amsterdam UMC
      address:
         name:Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
         type:PostalAddress
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
      address:
         name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
         type:PostalAddress
      name:Universitat Autonoma de Barcelona
      address:
         name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
         type:PostalAddress
      name:German Competence Network Multiple Sclerosis (KKNMS)
      address:
         name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
         type:PostalAddress
      name:University of Münster
      address:
         name:Department of Neurology, Klinik für Neurologie mit Institut für Translationale Neurologie, University of Münster, Münster, Germany
         type:PostalAddress
      name:Mayo Clinic Florida
      address:
         name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
         type:PostalAddress
      name:University Hospital Mutua de Terrassa
      address:
         name:Movement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain
         type:PostalAddress
      name:Fundacio per la Recerca Biomedica I Social Mutua Terrassa
      address:
         name:Fundacio per la Recerca Biomedica I Social Mutua Terrassa, Terrassa, Spain
         type:PostalAddress
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
      address:
         name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
         type:PostalAddress
      name:University Hospital “Marques de Valdecilla”
      address:
         name:University Hospital “Marques de Valdecilla”, Santander, Spain
         type:PostalAddress
      name:IDIVAL
      address:
         name:IDIVAL, Santander, Spain
         type:PostalAddress
      name:Mayo Clinic Minnesota
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      name:Mayo Clinic Minnesota
      address:
         name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
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         type:PostalAddress
      name:Mayo Clinic Florida
      address:
         name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
         type:PostalAddress
      name:Delft University of Technology
      address:
         name:Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands
         type:PostalAddress
      name:Mayo Clinic Florida
      address:
         name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
         type:PostalAddress
      name:Universitat Internacional de Catalunya
      address:
         name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
         type:PostalAddress
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
      address:
         name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
         type:PostalAddress
      name:University of Bonn
      address:
         name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
         type:PostalAddress
      name:DZNE, German Center for Neurodegenerative Diseases
      address:
         name:DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany
         type:PostalAddress
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      address:
         name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
         type:PostalAddress
      name:Universitat Autonoma de Barcelona
      address:
         name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
         type:PostalAddress
      name:University Hospital Cologne
      address:
         name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
         type:PostalAddress
      name:University Hospital Cologne
      address:
         name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
         type:PostalAddress
      name:Fundación Instituto Leloir-IIBBA-CONICET
      address:
         name:Fundación Instituto Leloir-IIBBA-CONICET, Buenos Aires, Argentina
         type:PostalAddress
      name:Universitat Internacional de Catalunya
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      name:Carmen Lage
      affiliation:
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
            name:University Hospital “Marques de Valdecilla”
            address:
               name:University Hospital “Marques de Valdecilla”, Santander, Spain
               type:PostalAddress
            type:Organization
            name:IDIVAL
            address:
               name:IDIVAL, Santander, Spain
               type:PostalAddress
            type:Organization
      name:Itziar de Rojas
      affiliation:
            name:Universitat Internacional de Catalunya
            address:
               name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Steffi Riedel-Heller
      affiliation:
            name:University of Leipzig
            address:
               name:Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany
               type:PostalAddress
            type:Organization
      name:Ignacio Illán-Gala
      affiliation:
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
            name:Universitat Autonoma de Barcelona
            address:
               name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Wei Wei
      affiliation:
            name:University of Cambridge
            address:
               name:Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Bernard Jeune
      affiliation:
            name:University of Southern Denmark
            address:
               name:Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
      name:Adelina Orellana
      affiliation:
            name:Universitat Internacional de Catalunya
            address:
               name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Florian Then Bergh
      affiliation:
            name:German Competence Network Multiple Sclerosis (KKNMS)
            address:
               name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
               type:PostalAddress
            type:Organization
            name:University of Leipzig
            address:
               name:Department of Neurology, University of Leipzig, Leipzig, Germany
               type:PostalAddress
            type:Organization
      name:Xue Wang
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Marc Hulsman
      affiliation:
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:Delft University of Technology
            address:
               name:Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands
               type:PostalAddress
            type:Organization
      name:Nina Beker
      affiliation:
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Niccolo Tesi
      url:http://orcid.org/0000-0002-1413-5091
      affiliation:
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:Delft University of Technology
            address:
               name:Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands
               type:PostalAddress
            type:Organization
      name:Christopher M. Morris
      affiliation:
            name:Newcastle University
            address:
               name:Newcastle Brain Tissue Resource, Edwardson Building, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
               type:PostalAddress
            type:Organization
      name:Begoña Indakoetxea
      affiliation:
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
            name:Instituto Biodonostia
            address:
               name:Instituto Biodonostia, San Sebastian, Spain
               type:PostalAddress
            type:Organization
            name:Hospital Universitario San Sebastian
            address:
               name:Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
               type:PostalAddress
            type:Organization
      name:Lyduine E. Collij
      affiliation:
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Martin Scherer
      affiliation:
            name:University Medical Center
            address:
               name:Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, Germany
               type:PostalAddress
            type:Organization
      name:Estrella Morenas-Rodríguez
      affiliation:
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
            name:Universitat Autonoma de Barcelona
            address:
               name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:James W. Ironside
      affiliation:
            name:University of Edinburgh
            address:
               name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
      name:Bart N. M. van Berckel
      affiliation:
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Daniel Alcolea
      affiliation:
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
            name:Universitat Autonoma de Barcelona
            address:
               name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Heinz Wiendl
      affiliation:
            name:German Competence Network Multiple Sclerosis (KKNMS)
            address:
               name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
               type:PostalAddress
            type:Organization
            name:University of Münster
            address:
               name:Department of Neurology, Klinik für Neurologie mit Institut für Translationale Neurologie, University of Münster, Münster, Germany
               type:PostalAddress
            type:Organization
      name:Samantha L. Strickland
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Pau Pastor
      affiliation:
            name:University Hospital Mutua de Terrassa
            address:
               name:Movement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Fundacio per la Recerca Biomedica I Social Mutua Terrassa
            address:
               name:Fundacio per la Recerca Biomedica I Social Mutua Terrassa, Terrassa, Spain
               type:PostalAddress
            type:Organization
      name:Eloy Rodríguez Rodríguez
      affiliation:
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
            name:University Hospital “Marques de Valdecilla”
            address:
               name:University Hospital “Marques de Valdecilla”, Santander, Spain
               type:PostalAddress
            type:Organization
            name:IDIVAL
            address:
               name:IDIVAL, Santander, Spain
               type:PostalAddress
            type:Organization
      name:Bradley F. Boeve
      affiliation:
            name:Mayo Clinic Minnesota
            address:
               name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Ronald C. Petersen
      affiliation:
            name:Mayo Clinic Minnesota
            address:
               name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Tanis J. Ferman
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Psychiatry and Psychology, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Jay A. van Gerpen
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Marcel J. T. Reinders
      affiliation:
            name:Delft University of Technology
            address:
               name:Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands
               type:PostalAddress
            type:Organization
      name:Ryan J. Uitti
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Lluís Tárraga
      affiliation:
            name:Universitat Internacional de Catalunya
            address:
               name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Wolfgang Maier
      affiliation:
            name:University of Bonn
            address:
               name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
               type:PostalAddress
            type:Organization
            name:DZNE, German Center for Neurodegenerative Diseases
            address:
               name:DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany
               type:PostalAddress
            type:Organization
      name:Oriol Dols-Icardo
      affiliation:
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
            name:Universitat Autonoma de Barcelona
            address:
               name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Amit Kawalia
      affiliation:
            name:University Hospital Cologne
            address:
               name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
               type:PostalAddress
            type:Organization
      name:Maria Carolina Dalmasso
      affiliation:
            name:University Hospital Cologne
            address:
               name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
               type:PostalAddress
            type:Organization
            name:Fundación Instituto Leloir-IIBBA-CONICET
            address:
               name:Fundación Instituto Leloir-IIBBA-CONICET, Buenos Aires, Argentina
               type:PostalAddress
            type:Organization
      name:Mercè Boada
      affiliation:
            name:Universitat Internacional de Catalunya
            address:
               name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Uwe K. Zettl
      affiliation:
            name:German Competence Network Multiple Sclerosis (KKNMS)
            address:
               name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
               type:PostalAddress
            type:Organization
            name:University of Rostock
            address:
               name:Department of Neurology, University of Rostock, Rostock, Germany
               type:PostalAddress
            type:Organization
      name:Natasja M. van Schoor
      affiliation:
            name:Amsterdam Public Health Research Institute
            address:
               name:Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Marian Beekman
      affiliation:
            name:Leiden University Medical Center
            address:
               name:Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:Mariet Allen
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Eliezer Masliah
      affiliation:
            name:National Institute on Aging, National Institutes of Health
            address:
               name:Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Adolfo López de Munain
      affiliation:
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
            name:Instituto Biodonostia
            address:
               name:Instituto Biodonostia, San Sebastian, Spain
               type:PostalAddress
            type:Organization
            name:Hospital Universitario San Sebastian
            address:
               name:Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
               type:PostalAddress
            type:Organization
      name:Alexander Pantelyat
      affiliation:
            name:Johns Hopkins University Medical Center
            address:
               name:Department of Neurology, Johns Hopkins University Medical Center, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Zbigniew K. Wszolek
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Owen A. Ross
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Dennis W. Dickson
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Neill R. Graff-Radford
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:David Knopman
      affiliation:
            name:Mayo Clinic Minnesota
            address:
               name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Rosa Rademakers
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Afina W. Lemstra
      affiliation:
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Yolande A. L. Pijnenburg
      affiliation:
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Philip Scheltens
      url:http://orcid.org/0000-0002-1046-6408
      affiliation:
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Thomas Gasser
      affiliation:
            name:University of Tuebingen
            address:
               name:Center of Neurology, Department of Neurodegenerative diseases, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
               type:PostalAddress
            type:Organization
      name:Patrick F Chinnery
      affiliation:
            name:University of Cambridge
            address:
               name:Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Bernhard Hemmer
      affiliation:
            name:Technical University of Munich
            address:
               name:Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
               type:PostalAddress
            type:Organization
            name:German Competence Network Multiple Sclerosis (KKNMS)
            address:
               name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
               type:PostalAddress
            type:Organization
            name:Munich Cluster for Systems Neurology (SyNergy)
            address:
               name:Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
               type:PostalAddress
            type:Organization
      name:Martijn A. Huisman
      affiliation:
            name:Amsterdam Public Health Research Institute
            address:
               name:Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:VU University
            address:
               name:Department of Sociology, VU University, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Juan Troncoso
      affiliation:
            name:Johns Hopkins University Medical Center
            address:
               name:Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Fermin Moreno
      affiliation:
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
            name:Instituto Biodonostia
            address:
               name:Instituto Biodonostia, San Sebastian, Spain
               type:PostalAddress
            type:Organization
            name:Hospital Universitario San Sebastian
            address:
               name:Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
               type:PostalAddress
            type:Organization
      name:Ellen A. Nohr
      affiliation:
            name:University of Southern Denmark
            address:
               name:Research Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
      name:Thorkild I. A. Sørensen
      affiliation:
            name:Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics
            address:
               name:Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Copenhagen, Denmark
               type:PostalAddress
            type:Organization
            name:University of Copenhagen
            address:
               name:Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
               type:PostalAddress
            type:Organization
            name:Bristol University
            address:
               name:MRC Integrative Epidemiology Unit, Bristol University, Bristol, UK
               type:PostalAddress
            type:Organization
      name:Peter Heutink
      affiliation:
            name:German Center for Neurodegenerative Diseases (DZNE)-Tübingen
            address:
               name:German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany
               type:PostalAddress
            type:Organization
            name:University of Tübingen
            address:
               name:Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:Pascual Sánchez-Juan
      affiliation:
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
            name:University Hospital “Marques de Valdecilla”
            address:
               name:University Hospital “Marques de Valdecilla”, Santander, Spain
               type:PostalAddress
            type:Organization
            name:IDIVAL
            address:
               name:IDIVAL, Santander, Spain
               type:PostalAddress
            type:Organization
      name:Danielle Posthuma
      affiliation:
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Jordi Clarimón
      affiliation:
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
            name:Universitat Autonoma de Barcelona
            address:
               name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Kaare Christensen
      affiliation:
            name:University of Southern Denmark
            address:
               name:The Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:Odense University Hospital
            address:
               name:Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
            name:Odense University Hospital
            address:
               name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
               type:PostalAddress
            type:Organization
      name:Nilüfer Ertekin-Taner
      affiliation:
            name:Mayo Clinic Florida
            address:
               name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
            name:Mayo Clinic Florida
            address:
               name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
               type:PostalAddress
            type:Organization
      name:Sonja W. Scholz
      affiliation:
            name:National Institute of Neurological Disorders and Stroke
            address:
               name:Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, USA
               type:PostalAddress
            type:Organization
            name:Johns Hopkins University Medical Center
            address:
               name:Department of Neurology, Johns Hopkins University Medical Center, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Alfredo Ramirez
      affiliation:
            name:University of Bonn
            address:
               name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
               type:PostalAddress
            type:Organization
            name:University Hospital Cologne
            address:
               name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
               type:PostalAddress
            type:Organization
      name:Agustín Ruiz
      affiliation:
            name:Universitat Internacional de Catalunya
            address:
               name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED)
            address:
               name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Eline Slagboom
      affiliation:
            name:Leiden University Medical Center
            address:
               name:Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
            name:Dutch Society for Research on Ageing
            address:
               name:Dutch Society for Research on Ageing, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:Wiesje M. van der Flier
      affiliation:
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Henne Holstege
      url:http://orcid.org/0000-0002-7688-3087
      affiliation:
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
      name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
      name:DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany
      name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
      name:Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
      name:Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands
      name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
      name:Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
      name:Interdepartmental Program in Bioinformatics, University of California, Los Angeles, USA
      name:Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden
      name:Max Planck Institute of Psychiatry, Munich, Germany
      name:Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
      name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
      name:Movement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain
      name:Fundacio per la Recerca Biomedica I Social Mutua Terrassa, Terrassa, Spain
      name:German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany
      name:Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
      name:Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
      name:Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
      name:Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK
      name:The Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
      name:Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, USA
      name:Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
      name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
      name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
      name:DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
      name:Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
      name:Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
      name:Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
      name:Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
      name:Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden
      name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
      name:Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg‐Eppendorf, Hamburg, Germany
      name:Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, USA
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Instituto Biodonostia, San Sebastian, Spain
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:University Hospital “Marques de Valdecilla”, Santander, Spain
      name:IDIVAL, Santander, Spain
      name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
      name:Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
      name:Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
      name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
      name:Department of Neurology, University of Leipzig, Leipzig, Germany
      name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands
      name:Newcastle Brain Tissue Resource, Edwardson Building, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Instituto Biodonostia, San Sebastian, Spain
      name:Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
      name:Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, Germany
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
      name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
      name:Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
      name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
      name:Department of Neurology, Klinik für Neurologie mit Institut für Translationale Neurologie, University of Münster, Münster, Germany
      name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
      name:Movement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain
      name:Fundacio per la Recerca Biomedica I Social Mutua Terrassa, Terrassa, Spain
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:University Hospital “Marques de Valdecilla”, Santander, Spain
      name:IDIVAL, Santander, Spain
      name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
      name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
      name:Department of Psychiatry and Psychology, Mayo Clinic Florida, Jacksonville, USA
      name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
      name:Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands
      name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
      name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
      name:DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
      name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
      name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
      name:Fundación Instituto Leloir-IIBBA-CONICET, Buenos Aires, Argentina
      name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
      name:Department of Neurology, University of Rostock, Rostock, Germany
      name:Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
      name:Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
      name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
      name:Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, USA
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Instituto Biodonostia, San Sebastian, Spain
      name:Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
      name:Department of Neurology, Johns Hopkins University Medical Center, Baltimore, USA
      name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
      name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
      name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
      name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
      name:Department of Neurology, Mayo Clinic Minnesota, Rochester, USA
      name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Center of Neurology, Department of Neurodegenerative diseases, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
      name:Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
      name:MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK
      name:Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
      name:German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany
      name:Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
      name:Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
      name:Department of Sociology, VU University, Amsterdam, The Netherlands
      name:Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, USA
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Instituto Biodonostia, San Sebastian, Spain
      name:Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain
      name:Research Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
      name:Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Copenhagen, Denmark
      name:Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
      name:MRC Integrative Epidemiology Unit, Bristol University, Bristol, UK
      name:German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany
      name:Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:University Hospital “Marques de Valdecilla”, Santander, Spain
      name:IDIVAL, Santander, Spain
      name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
      name:The Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
      name:Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
      name:Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
      name:Department of Neuroscience, Mayo Clinic Florida, Jacksonville, USA
      name:Department of Neurology, Mayo Clinic Florida, Jacksonville, USA
      name:Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, USA
      name:Department of Neurology, Johns Hopkins University Medical Center, Baltimore, USA
      name:Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany
      name:Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany
      name:Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
      name:Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
      name:Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
      name:Dutch Society for Research on Ageing, Leiden, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands