We are analyzing https://link.springer.com/article/10.1007/s10654-018-0451-3.

Title:
The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description | European Journal of Epidemiology
Description:
Although the incidence of dementia increases exponentially with age, some individuals reach more than 100 years with fully retained cognitive abilities. To identify the characteristics associated with the escape or delay of cognitive decline, we initiated the 100-plus Study ( www.100plus.nl ). The 100-plus Study is an on-going prospective cohort study of Dutch centenarians who self-reported to be cognitively healthy, their first-degree family members and their respective partners. We collect demographics, life history, medical history, genealogy, neuropsychological data and blood samples. Centenarians are followed annually until death. PET–MRI scans and feces donation are optional. Almost 30% of the centenarians agreed to post-mortem brain donation. To date (September 2018), 332 centenarians were included in the study. We analyzed demographic statistics of the first 300 centenarians (25% males) included in the cohort. Centenarians came from higher socio-economic classes and had higher levels of education compared to their birth cohort; alcohol consumption of centenarians was similar, and most males smoked during their lifetime. At baseline, the centenarians had a median MMSE score of 25 points (IQR 22.0–27.5); most centenarians lived independently, retained hearing and vision abilities and were independently mobile. Mortality was associated with cognitive functioning: centenarians with a baseline MMSE score ≥ 26 points had a mortality percentage of 17% per annual year  in the second year after baseline, while centenarians with a baseline MMSE score < 26 points had a mortality of  42% per annual year (p = 0.003). The cohort was 2.1-fold enriched with the neuroprotective APOE-ε2 allele relative to 60–80 year-old population controls (p = 4.8 × 10−7), APOE-ε3 was unchanged and the APOE-ε4 allele was 2.3-fold depleted (p = 6.3 × 10−7). Comprehensive characterization of the 100-plus cohort of cognitively healthy centenarians might reveal protective factors that explain the physiology of long-term preserved cognitive health.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

centenarians, google, scholar, pubmed, study, article, cognitive, cohort, mortality, centenarian, dementia, years, cas, health, age, birth, males, mmse, incidence, fig, netherlands, visit, data, disease, van, esmpdf, central, baseline, dutch, table, allele, females, test, rate, healthy, brain, apoeε, factors, cognitively, individuals, decline, compared, aging, born, higher, population, followup, education, points, year,

Topics {✒️}

nl/nl-nl/nieuws/2017/20/aantal-100-plussers-verdubbeld dm=slnl&pa=82690ned&d1=0&d2= org/education/information/nfsunesco/doc/isced_1997 hanne meijers-heijboer elite-upper middle class article download pdf =26190&pa=80333ned&la=nl mini–mental state examination hendrikje van andel-schipper determine socio-economic background aantal 100-plussers verdubbeld neuroprotective apoe-ε2 allele higher socio-economic classes higher socio-economic background post-war period typified ps contributed substantive support post-mortem brain donation apoe-ε4/ε4 genotype higher/middle socioeconomic classes ε4 allele carriers dropped high-throughput biomolecular techniques higher socio-economic status central bureau apoe-ε2/ε3 genotype centenarian—socio-economic background apoe-ε4 allele compared genotyped apoe-ε3/ε4 case–control association mapping open clinica database protective apoe-ε2 allele pet–ct brain scans prognosis period-life expectancy van den dungen pdf fig s4b-left socio-economic mortality differences �mini–mental state” fatal smoking-related diseases privacy choices/manage cookies pre-morbid intelligence socio-economic background de-la-camara md state med major age-related conditions revised cambridge examination full access apoe-ε4 allele moderate-good hearing abilities large centenarian meta-analysis socio-demographic correlates wais-iii administration

Questions {❓}

Clock-drawing: is it the ideal cognitive screening test?
Do Centenarians Get Dementia?
Payback time?
This raises several questions: what are the unique molecular mechanisms that cause resilience against age related decline?
What do we know about the cognitive status of supercentenarians?
Nl/Statweb/dome/?
Nl/Statweb/publication/?

Schema {🗺️}

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      headline:The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description
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         Prospective cohort study
         Centenarians
         Cognitive health longevity
         Epidemiology
         Public Health
         Infectious Diseases
         Cardiology
         Oncology
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            name:Vrije Universiteit Amsterdam, Amsterdam UMC
            address:
               name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
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            address:
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               type:PostalAddress
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PostalAddress:
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      name:Department of Clinical Genetics, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Department of Clinical Genetics, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Netherlands Interdisciplinary Demographic Institute (NIDI/KNAW), The Hague, The Netherlands
      name:Department of Clinical Genetics, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Department of Clinical Genetics, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
      name:Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands

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