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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
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We began analyzing https://link.springer.com/article/10.1007/s00401-006-0115-3, but it redirected us to https://link.springer.com/article/10.1007/s00401-006-0115-3. The analysis below is for the second page.

Title[redir]:
RAGE, LRP-1, and amyloid-beta protein in Alzheimer’s disease | Acta Neuropathologica
Description:
The receptor for advanced glycation end products (RAGE) is thought to be a primary transporter of β-amyloid across the blood–brain barrier (BBB) into the brain from the systemic circulation, while the low-density lipoprotein receptor-related protein (LRP)-1 mediates transport of β-amyloid out of the brain. To determine whether there are Alzheimer’s disease (AD)-related changes in these BBB-associated β-amyloid receptors, we studied RAGE, LRP-1, and β-amyloid in human elderly control and AD hippocampi. In control hippocampi, there was robust RAGE immunoreactivity in neurons, whereas microvascular staining was barely detectable. LRP-1 staining, in contrast, was clearly evident within microvessels but only weakly stained neurons. In AD cases, neuronal RAGE immunoreactivity was significantly decreased. An unexpected finding was the strongly positive microvascular RAGE immunoreactivity. No evidence for colocalization of RAGE and β-amyloid was seen within either microvessels or senile plaques. A reversed pattern was evident for LRP-1 in AD. There was very strong staining for LRP-1 in neurons, with minimal microvascular staining. Unlike RAGE, colocalization of LRP-1 and β-amyloid was clearly present within senile plaques but not microvessels. Western blot analysis revealed a much higher concentration of RAGE protein in AD hippocampi as compared with controls. Concentration of LRP-1 was increased in AD hippocampi, likely secondary to its colocalization with senile plaques. These data confirm that AD is associated with changes in the relative distribution of RAGE and LRP-1 receptors in human hippocampus. They also suggest that the proportion of amyloid within the brains of AD patients that is derived from the systemic circulation may be significant.

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Doi.org might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

article, google, scholar, alzheimers, cas, pubmed, disease, rage, lrp, protein, bloodbrain, barrier, brain, amyloid, receptor, βamyloid, receptorrelated, human, usa, amyloidbeta, john, lipoprotein, peptide, stern, zlokovic, privacy, cookies, content, acta, donahue, products, neurons, neurobiol, medical, data, publish, research, search, july, silverberg, transport, hippocampi, microvascular, staining, neuronal, plaques, access, aging, zhu, ghiso,

Topics {✒️}

blood–brain barrier permeability/leakage month download article/chapter ldl receptor-related protein-1 receptor-dependent cell stress beta-amyloid protein deposition beta-amyloid precursor protein amyloid-beta peptide neurotoxicity blood-brain barrier properties blood–brain barrier play receptor-mediated transport full article pdf amyloid-beta protein amyloid beta-protein amyloid precursor protein privacy choices/manage cookies ldl receptor family amyloid-beta peptide blood–brain barrier disease research fund alpha 2-macroglobulin receptor neuronal rage immunoreactivity β-amyloid receptors harvard medical school related subjects circulating human alzheimer central nervous system csf circulatory physiology robust rage immunoreactivity neurones accumulating amyloid brown medical school european economic area edmond sabo minimal microvascular staining normal-pressure hydrocephalus rhode island hospital conditions privacy policy human elderly control form amyloid plaques rage-abeta interactions accepting optional cookies wentian yang qian wu & edward rage protein article log main content log weakly stained neurons check access instant access zlokovic bv journal finder publish

Schema {🗺️}

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            name: Rhode Island Hospital and Brown Medical School
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            name: Rhode Island Hospital and Brown Medical School
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               name:Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, USA
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               name:Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, USA
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      name:Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, USA
      name:Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, USA
      name:Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, USA
      name:Department of Neurosurgery, Stanford University Medical Center and School of Medicine, Stanford, USA
      name:Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, USA
      name:Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, USA
      name:Cancer Biology Program, Division of Hematology-Oncology, Department of Medicine, Beth Israel-Deaconess Medical Center and Harvard Medical School, Boston, USA
      name:Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, USA
      name:Molecular Pathology Core, COBRE CCRD, Rhode Island Hospital and Brown Medical School, Providence, USA
      name:Core Image Analysis Laboratory, Rhode Island Hospital, Providence, USA
      name:Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, USA
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