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Title:
Ultrastructural heterogeneity in cerebral amyloid of Alzheimer's disease | Acta Neuropathologica
Description:
Cerebral amyloid deposits from five patients with presenile or senile cerebral disease of the Alzheimer type were stained with uranyl acetate and lead citrate or with periodic acid-thiocarbohydrazidesilver proteinate, and examined with traditional highresolution electron microscopy and with a goniometer tilting stage. In addition to a carbohydrate-rich matrix, we also consistently found local cell-derived vesicles within plaque and dyshoric amyloid. The most likely source for these vesicles appeared to be degenerate neurites. Amyloid fibrils were intimately associated with plasmalemmata, particularly those of degenerate neurites, which supported a neuronal origin for the amyloid fibril of Alzheimer
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google, scholar, amyloid, disease, senile, alzheimers, cerebral, amyloidosis, article, neuropathol, protein, plaques, acta, plaque, brain, med, powers, arch, glenner, pathol, neurol, ultrastructural, fibrils, berl, privacy, cookies, content, electron, access, cohen, engl, dementia, york, virchow, exp, publish, research, search, deposits, presenile, alzheimer, origin, fibril, cerebrovascular, nature, study, characterization, westermark, usa, analysis,
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month download article/chapter periodic acid-thiocarbohydrazidesilver proteinate cross-bridges mediate anterograde senile cerebral amyloid-evidence retrograde vesicle transport privacy choices/manage cookies l'angiopathie congophile full article pdf cerebrovascular amyloid protein amyloidΞ² protein gene electron microscopic observations carbohydrate-rich matrix traditional concepts based van keuren ml cell-surface receptor electron microscopical study european economic area scope submit manuscript goniometer tilting stage atomic-level differences monoclonal antibodies raised monoclonal antibodies show appleton-century-crofts fluorescent antibody technique presynaptic nerve terminals st george-hyslop x-ray scattering normal islet cells senile plaque amyloid conditions privacy policy pathogenic amyloid proteins understanding amyloid structures senile cerebral disease electron histochemical study senile cerebral amyloid aa amyloid fibrils amyloid research related subjects accepting optional cookies cerebral amyloid angiopathy cerebral blood vessels experimental hamster amyloid amyloid fibril proteins main content log article powers ultrastructural heterogeneity senile cerebral amyloidosis check access instant access journal finder publish
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headline:Ultrastructural heterogeneity in cerebral amyloid of Alzheimer's disease
description:Cerebral amyloid deposits from five patients with presenile or senile cerebral disease of the Alzheimer type were stained with uranyl acetate and lead citrate or with periodic acid-thiocarbohydrazidesilver proteinate, and examined with traditional highresolution electron microscopy and with a goniometer tilting stage. In addition to a carbohydrate-rich matrix, we also consistently found local cell-derived vesicles within plaque and dyshoric amyloid. The most likely source for these vesicles appeared to be degenerate neurites. Amyloid fibrils were intimately associated with plasmalemmata, particularly those of degenerate neurites, which supported a neuronal origin for the amyloid fibril of Alzheimer's disease.
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Alzheimer's disease
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headline:Ultrastructural heterogeneity in cerebral amyloid of Alzheimer's disease
description:Cerebral amyloid deposits from five patients with presenile or senile cerebral disease of the Alzheimer type were stained with uranyl acetate and lead citrate or with periodic acid-thiocarbohydrazidesilver proteinate, and examined with traditional highresolution electron microscopy and with a goniometer tilting stage. In addition to a carbohydrate-rich matrix, we also consistently found local cell-derived vesicles within plaque and dyshoric amyloid. The most likely source for these vesicles appeared to be degenerate neurites. Amyloid fibrils were intimately associated with plasmalemmata, particularly those of degenerate neurites, which supported a neuronal origin for the amyloid fibril of Alzheimer's disease.
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Alzheimer's disease
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