Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s00281-023-00993-5, but it redirected us to https://link.springer.com/article/10.1007/s00281-023-00993-5. The analysis below is for the second page.

Title[redir]:
The role of circulating cell-free DNA as an inflammatory mediator after stroke | Seminars in Immunopathology
Description:
Stroke is the second leading cause of death worldwide and a leading cause of disability. Clinical and experimental studies highlighted the complex role of the immune system in the pathophysiology of stroke. Ischemic brain injury leads to the release of cell-free DNA, a damage-associated molecular pattern, which binds to pattern recognition receptors on immune cells such as toll-like receptors and cytosolic inflammasome sensors. The downstream signaling cascade then induces a rapid inflammatory response. In this review, we are highlighting the characteristics of cell-free DNA and how these can affect a local as well as a systemic response after stroke. For this purpose, we screened literature on clinical studies investigating cell-free DNA concentration and properties after brain ischemia. We report the current understanding for mechanisms of DNA uptake and sensing in the context of post-stroke inflammation. Moreover, we compare possible treatment options targeting cell-free DNA, DNA-sensing pathways, and the downstream mediators. Finally, we describe clinical implications of this inflammatory pathway for stroke patients, open questions, and potential future research directions.

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Graphic Design

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We see no obvious way the site makes money.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

pubmed, stroke, article, google, scholar, dna, cas, cfdna, central, aim, patients, ischemic, blood, tlr, cellfree, dnase, activation, inflammasome, immune, studies, injury, response, clinical, brain, cell, systemic, cells, binding, inflammatory, plasma, concentrations, release, inflammation, increased, outcome, treatment, tissue, hmgb, signaling, ilβ, receptor, circulating, sensing, pathway, leads, concentration, acute, cgas, human, experimental,

Topics {✒️}

post-stroke double-strand cfdna c-type lectin-receptor-2d ischemia-reperfusion injury-induced myocardial preclinical deep-vein thrombosis cgas-sting-mediated interferon response cytokine-induced sickness behavior nf-kb signaling pathway neuroprotective steroids 17β-estradiol article download pdf cerebral ischemia/reperfusion injury cell-free deoxyribonucleic acid cell-free dna comprises dsdna = double-stranded dna k-rich histone tail long-term recovery index nf-κb-mediated transcription cyclic gmp-amp synthase circulating cell-free dna tissue-specific cell death dna-stimulated cell death rupture-prone carotid-plaques neutrophil extracellular traps cells releasing tnf-α recruit tank-binding kinase short-term neurological outcome nf-kappab activation intra-tumoral dendritic cells fetal cell-free dna microglial cgas-sting pathway quantitative real-time pcr sputum cell-free dna mrs = modified rankin score cell-free plasma dna sense dna-bound proteins myd88-dependent signaling cascade 4-sulfonic calixarenes proinflammatory cytokine il-1β tlr9-p38 mapk signaling tissue-type plasminogen activator cell death–derived cfdna short-term disease severity cfdna-driven immunological cascade systemic immune alterations recent post-stroke therapy serum cell-free dna anti-il-1β treatment proinflammatory cytokine il-β il-1β neutralization analyzed post-injury immunosuppression subcutaneous il-1ra application

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The role of circulating cell-free DNA as an inflammatory mediator after stroke
         description:Stroke is the second leading cause of death worldwide and a leading cause of disability. Clinical and experimental studies highlighted the complex role of the immune system in the pathophysiology of stroke. Ischemic brain injury leads to the release of cell-free DNA, a damage-associated molecular pattern, which binds to pattern recognition receptors on immune cells such as toll-like receptors and cytosolic inflammasome sensors. The downstream signaling cascade then induces a rapid inflammatory response. In this review, we are highlighting the characteristics of cell-free DNA and how these can affect a local as well as a systemic response after stroke. For this purpose, we screened literature on clinical studies investigating cell-free DNA concentration and properties after brain ischemia. We report the current understanding for mechanisms of DNA uptake and sensing in the context of post-stroke inflammation. Moreover, we compare possible treatment options targeting cell-free DNA, DNA-sensing pathways, and the downstream mediators. Finally, we describe clinical implications of this inflammatory pathway for stroke patients, open questions, and potential future research directions.
         datePublished:2023-05-22T00:00:00Z
         dateModified:2023-05-22T00:00:00Z
         pageStart:411
         pageEnd:425
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s00281-023-00993-5
         keywords:
            Cell-free DNA
            Tissue injury
            Stroke
            Inflammation
            Inflammasome
            Immunology
            Internal Medicine
            Pathology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-023-00993-5/MediaObjects/281_2023_993_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-023-00993-5/MediaObjects/281_2023_993_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-023-00993-5/MediaObjects/281_2023_993_Fig3_HTML.png
         isPartOf:
            name:Seminars in Immunopathology
            issn:
               1863-2300
               1863-2297
            volumeNumber:45
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Stefan Roth
               affiliation:
                     name:University Hospital, LMU Munich
                     address:
                        name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Saskia R. Wernsdorf
               affiliation:
                     name:University Hospital, LMU Munich
                     address:
                        name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Arthur Liesz
               url:http://orcid.org/0000-0002-9069-2594
               affiliation:
                     name:University Hospital, LMU Munich
                     address:
                        name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
                        type:PostalAddress
                     type:Organization
                     name:Munich Cluster for Systems Neurology (SyNergy)
                     address:
                        name:Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The role of circulating cell-free DNA as an inflammatory mediator after stroke
      description:Stroke is the second leading cause of death worldwide and a leading cause of disability. Clinical and experimental studies highlighted the complex role of the immune system in the pathophysiology of stroke. Ischemic brain injury leads to the release of cell-free DNA, a damage-associated molecular pattern, which binds to pattern recognition receptors on immune cells such as toll-like receptors and cytosolic inflammasome sensors. The downstream signaling cascade then induces a rapid inflammatory response. In this review, we are highlighting the characteristics of cell-free DNA and how these can affect a local as well as a systemic response after stroke. For this purpose, we screened literature on clinical studies investigating cell-free DNA concentration and properties after brain ischemia. We report the current understanding for mechanisms of DNA uptake and sensing in the context of post-stroke inflammation. Moreover, we compare possible treatment options targeting cell-free DNA, DNA-sensing pathways, and the downstream mediators. Finally, we describe clinical implications of this inflammatory pathway for stroke patients, open questions, and potential future research directions.
      datePublished:2023-05-22T00:00:00Z
      dateModified:2023-05-22T00:00:00Z
      pageStart:411
      pageEnd:425
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00281-023-00993-5
      keywords:
         Cell-free DNA
         Tissue injury
         Stroke
         Inflammation
         Inflammasome
         Immunology
         Internal Medicine
         Pathology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-023-00993-5/MediaObjects/281_2023_993_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-023-00993-5/MediaObjects/281_2023_993_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00281-023-00993-5/MediaObjects/281_2023_993_Fig3_HTML.png
      isPartOf:
         name:Seminars in Immunopathology
         issn:
            1863-2300
            1863-2297
         volumeNumber:45
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Stefan Roth
            affiliation:
                  name:University Hospital, LMU Munich
                  address:
                     name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Saskia R. Wernsdorf
            affiliation:
                  name:University Hospital, LMU Munich
                  address:
                     name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Arthur Liesz
            url:http://orcid.org/0000-0002-9069-2594
            affiliation:
                  name:University Hospital, LMU Munich
                  address:
                     name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:Munich Cluster for Systems Neurology (SyNergy)
                  address:
                     name:Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Seminars in Immunopathology
      issn:
         1863-2300
         1863-2297
      volumeNumber:45
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University Hospital, LMU Munich
      address:
         name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
         type:PostalAddress
      name:University Hospital, LMU Munich
      address:
         name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
         type:PostalAddress
      name:University Hospital, LMU Munich
      address:
         name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
         type:PostalAddress
      name:Munich Cluster for Systems Neurology (SyNergy)
      address:
         name:Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Stefan Roth
      affiliation:
            name:University Hospital, LMU Munich
            address:
               name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Saskia R. Wernsdorf
      affiliation:
            name:University Hospital, LMU Munich
            address:
               name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
               type:PostalAddress
            type:Organization
      name:Arthur Liesz
      url:http://orcid.org/0000-0002-9069-2594
      affiliation:
            name:University Hospital, LMU Munich
            address:
               name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
               type:PostalAddress
            type:Organization
            name:Munich Cluster for Systems Neurology (SyNergy)
            address:
               name:Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
      name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
      name:Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany
      name:Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

External Links {🔗}(711)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Backbone.js
  • Clipboard.js
  • Prism.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

5.48s.