We are analyzing https://link.springer.com/article/10.1007/s13311-016-0483-x.

Title:
Inflammation and Stroke: An Overview | Neurotherapeutics
Description:
The immune response to acute cerebral ischemia is a major factor in stroke pathobiology and outcome. While the immune response starts locally in occluded and hypoperfused vessels and the ischemic brain parenchyma, inflammatory mediators generated in situ propagate through the organism as a whole. This “spillover” leads to a systemic inflammatory response first, followed by immunosuppression aimed at dampening the potentially harmful proinflammatory milieu. In this overview we will outline the inflammatory cascade from its starting point in the vasculature of the ischemic brain to the systemic immune response elicited by brain ischemia. Potential immunomodulatory therapeutic approaches, including preconditioning and immune cell therapy will also be discussed.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, stroke, google, scholar, article, cas, ischemic, cells, brain, immune, ischemia, central, injury, cerebral, response, cell, mice, preconditioning, blood, activation, system, acute, inflammatory, increased, outcome, inflammation, transient, occlusion, receptor, role, peripheral, mca, protein, flow, expression, tolerance, complement, experimental, intestinal, tissue, contribute, microglia, studies, regulatory, bone, microbiota, neurosci, leukocytes, found, spleen,

Topics {✒️}

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors n-methyl-d-aspartate receptor 2a n-methyl-d-aspartate mitochondrial-derived n-formyl peptides antigen-specific t-cell reactivity stenzel-poore mp mmp-9-positive neutrophil infiltration germ-free animals prevents blood-brain barrier breakdown bone marrow-derived cells ischaemia-induced ventricular arrhythmias induce t-cell proliferation antigen-specific immune reactions adhesion molecule p-selectin blood-borne cell recruitment ccaat/enhancer-binding protein central nervous system antigen-presenting cells loaded compromised blood–brain barrier mannose binding-lectin deficiency mannose-binding lectin deficiency peripheral t-cell response antibiotic-induced microbial dysbiosis eliminating proliferating microglia/macrophages mediate stress responses garcia-bonilla protease-activated receptor signalling microbiota–gut–brain axis bone marrow-derived wild-type mice transplanted b-cell-deficient mice nitric oxide pathway de freitas gr stem-cell therapies de simoni m il-17-secreting γδt cells acute cerebrovascular disease myocardial infarct size drug administration-approved treatments monocyte-derived macrophages contribute intra-arterial delivery stem cell factor membrane attack complex cerebrovascular regulation induced transient mca occlusion increase anti-inflammatory/type myelin basic protein mind research institute cord blood cells antigen-presenting cells

Questions {❓}

Coagulation and innate immune responses: can we view them separately?
The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct?

Schema {🗺️}

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         headline:Inflammation and Stroke: An Overview
         description:The immune response to acute cerebral ischemia is a major factor in stroke pathobiology and outcome. While the immune response starts locally in occluded and hypoperfused vessels and the ischemic brain parenchyma, inflammatory mediators generated in situ propagate through the organism as a whole. This “spillover” leads to a systemic inflammatory response first, followed by immunosuppression aimed at dampening the potentially harmful proinflammatory milieu. In this overview we will outline the inflammatory cascade from its starting point in the vasculature of the ischemic brain to the systemic immune response elicited by brain ischemia. Potential immunomodulatory therapeutic approaches, including preconditioning and immune cell therapy will also be discussed.
         datePublished:2016-10-11T00:00:00Z
         dateModified:2016-10-11T00:00:00Z
         pageStart:661
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            Neurosciences
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            Neurosurgery
            Neurobiology
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      headline:Inflammation and Stroke: An Overview
      description:The immune response to acute cerebral ischemia is a major factor in stroke pathobiology and outcome. While the immune response starts locally in occluded and hypoperfused vessels and the ischemic brain parenchyma, inflammatory mediators generated in situ propagate through the organism as a whole. This “spillover” leads to a systemic inflammatory response first, followed by immunosuppression aimed at dampening the potentially harmful proinflammatory milieu. In this overview we will outline the inflammatory cascade from its starting point in the vasculature of the ischemic brain to the systemic immune response elicited by brain ischemia. Potential immunomodulatory therapeutic approaches, including preconditioning and immune cell therapy will also be discussed.
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      dateModified:2016-10-11T00:00:00Z
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         ischemia
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         Neurosurgery
         Neurobiology
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      name:Costantino Iadecola
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PostalAddress:
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      name:Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, USA

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