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We began analyzing https://link.springer.com/article/10.1007/s00280-018-3549-0, but it redirected us to https://link.springer.com/article/10.1007/s00280-018-3549-0. The analysis below is for the second page.

Title[redir]:
Influence of gemcitabine chemotherapy on the microbiota of pancreatic cancer xenografted mice | Cancer Chemotherapy and Pharmacology
Description:
Background and aims Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of cancer-related death. We aimed to evaluate whether gemcitabine treatment shapes the gut microbiota in a model of PDAC xenografted mice. Materials and methods Pancreatic cancer xenograft mice were subjected to gemcitabine injection once per week for 3 weeks to assess the tumor volume as compared to control mice injected with normal saline solution. The composition of fecal microbiota, the activation of NF-kB pathway in cancer tissues and the serum metabolomics were further analyzed. Results Gemcitabine considerably decreases the proportion of Gram- positive Firmicutes (from about 39 to 17%) and the Gram- negative Bacteroidetes (from 38 to 17%) which are the two dominant phyla in the gut of tumor-bearing control mice. This downshift was replaced by an increase of Proteobacteria (Escherichia coli and Aeromonas hydrophila) from 15 up to 32% and Verrucomicrobia (Akkermansia muciniphila) from 5 to 33% in the gut of drug-receiving mice. An overall increase in inflammation-associated bacteria was observed upon gemcitabine. Consistently, activation of the NF-kB canonical pathway was found in cancer tissues from gemcitabine-treated mice. Serum metabolomics revealed a significant decrease of the purine compounds inosine and xanthine, and a decreasing trend for their metabolically-related molecule hypoxanthine. Discussion Understanding chemotherapy side effects may explain the lack of activity or the chemoresistant processes and it may help to set up strategies to improve the effectiveness of therapy.

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

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Custom-built

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Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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We can't see how the site brings in money.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Doi.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, central, pancreatic, microbiota, gut, chemotherapy, adamberg, intestinal, butyrate, mice, inflammation, gemcitabine, human, research, treatment, microbiome, role, panebianco, pazienza, gastroenterol, clin, pharmacol, author, privacy, cookies, data, kaarel, jaagura, review, med, disease, health, gastrointestinal, cells, inflammatory, tallinn, content, publish, search, vilu, valerio, adenocarcinoma, metabolomics, inosine, access,

Topics {✒️}

month download article/chapter contributed reagents/materials/analysis tools 5-fluorouracil-induced gastrointestinal mucositis reg deficiency-induced autoimmunity integrative view metabolically-related molecule hypoxanthine chemotherapy-induced gastrointestinal toxicity male sprague–dawley rats valerio pazienza gram-negative spore formers tumor-bearing control mice nf-kb canonical pathway article cancer chemotherapy full article pdf pancreatic cancer cells intestinal microbiota dysbiosis chemotherapy-induced mucositis author correspondence gemcitabine-treated mice privacy choices/manage cookies advanced pancreatic cancer van laethem jl pdac xenografted mice pancreatic ductal adenocarcinoma laboratory animal care drug-receiving mice endotoxin-induced shock institutional animal care metastatic pancreatic adenocarcinoma lactobacillus reuteri inhibits article panebianco institutional research funding anti-inflammatory effects cancer-related death control mice injected gemcitabine treatment shapes kaarel adamberg nf-kb pathway tumour bearing rats gram- negative bacteroidetes advanced pancreatic carcinoma cancer prev res chronic gastrointestinal disease inflammatory bowel disease european economic area check access microbial community imbalances extrinsic apoptotic pathways clostridium difficile infection instant access

Questions {❓}

  • Bien J, Palagani V, Bozko P (2013) The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease?
  • Nguyen TL, Vieira-Silva S, Liston A, Raes J (2015) How informative is the mouse for human gut microbiota research?
  • Scheppach W, Weiler F (2004) The butyrate story: old wine in new bottles?

Schema {🗺️}

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      name:Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia
      name:Center of Food and Fermentation Technologies, University of Tallinn, Tallinn, Estonia
      name:Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia
      name:Center of Food and Fermentation Technologies, University of Tallinn, Tallinn, Estonia
      name:Biostatistics Unit, I.R.C.C.S. “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, Italy
      name:Biostatistics Unit, I.R.C.C.S. “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, Italy
      name:Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia
      name:Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia
      name:Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia
      name:Center of Food and Fermentation Technologies, University of Tallinn, Tallinn, Estonia
      name:Gastroenterology Unit, I.R.C.C.S. “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, Italy
      name:Gastroenterology Unit, I.R.C.C.S. “Casa Sollievo della Sofferenza” Hospital, San Giovanni Rotondo, Italy
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