We are analyzing https://link.springer.com/chapter/10.1007/978-3-0348-0837-8_6.

Title:
The Role of Inflammation in Pancreatic Cancer | SpringerLink
Description:
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with an extremely poor prognosis. Inflammatory processes have emerged as key mediators of pancreatic cancer development and progression. In genetically engineered mouse models, induction of pancreatitis...
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Topics {✒️}

v-src-transformed cell lines rel/nf-kappab transcription factors transforming growth factor-beta constitutive nf-kappab/rel activity secreted interleukin-1alpha induces transforming growth factor-beta1 myeloid-derived suppressor cells tgf-beta signaling contributes tgf-beta-induced invasiveness tgf-beta downregulates pten tgf beta-related pathways mert erkan & helmut friess tlr4/myd88 signaling pathway sh2-phosphotyrosyl peptide interactions signaling tgf-beta receptors tgf-beta autocrine pathway transforming growth factor early nf-kappab activation pancreatic beta-cell development nf-kappab/rel activation epidermal growth factor kras-induced pancreatic tumorigenesis inhibiting oncogene-induced senescence ap-1-induced il-8 expression month download article/chapter nuclear factor-kappab nf-kappab activation pathway pancreatitis-induced inflammation contributes cox-2-negative pancreatic cancer interleukin-1alpha enhances urokinase plasminogen activator transcription factor stat3 specific cox-2 activity kappab-beta regulates rel/nf-kappab/ privacy choices/manage cookies device instant download tgfbeta signaling pathways pancreatic ductal adenocarcinoma nf-kappab pathway pancreatic stellate cells stat3 signaling pathway selective cox-2 inhibitor stimulates erk activation human pancreatic cancers human pancreatic adenocarcinomas canonical nf-kappab hormone-induced pancreatitis human pancreatic cancer inflammation-induced tumorigenesis

Questions {❓}

Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow?

Schema {🗺️}

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      headline:The Role of Inflammation in Pancreatic Cancer
      pageEnd:151
      pageStart:129
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-0348-0837-8.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
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            978-3-0348-0837-8
            978-3-0348-0836-1
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      author:
            name:Simone Hausmann
            affiliation:
                  name:Klinikum rechts der Isar, Technische Universität München
                  address:
                     name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bo Kong
            affiliation:
                  name:Klinikum rechts der Isar, Technische Universität München
                  address:
                     name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christoph Michalski
            affiliation:
                  name:Klinikum rechts der Isar, Technische Universität München
                  address:
                     name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mert Erkan
            affiliation:
                  name:Klinikum rechts der Isar, Technische Universität München
                  address:
                     name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Helmut Friess
            affiliation:
                  name:Klinikum rechts der Isar, Technische Universität München
                  address:
                     name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Pancreatic Cancer, Chronic Pancreatitis, Pancreatic Cancer Cell, Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer Cell Line
      description:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with an extremely poor prognosis. Inflammatory processes have emerged as key mediators of pancreatic cancer development and progression. In genetically engineered mouse models, induction of pancreatitis accelerates PDAC development, and patients with chronic pancreatitis are known to have a higher risk of developing pancreatic cancer. In recent years, much effort has been given to identify the underlying mechanisms that contribute to inflammation-induced tumorigenesis. Many inflammatory pathways have been identified and inhibitors have been developed in order to prevent cancer development and progression. In this chapter, we discuss the role of inflammatory pathways in the initiation and progression of pancreatic cancer as well as the role of inhibitors used in treatment and prevention of pancreatic cancer.
      datePublished:2014
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            address:
               name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
               type:PostalAddress
            type:Organization
      name:Bo Kong
      affiliation:
            name:Klinikum rechts der Isar, Technische Universität München
            address:
               name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
               type:PostalAddress
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      name:Christoph Michalski
      affiliation:
            name:Klinikum rechts der Isar, Technische Universität München
            address:
               name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
               type:PostalAddress
            type:Organization
      name:Mert Erkan
      affiliation:
            name:Klinikum rechts der Isar, Technische Universität München
            address:
               name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
               type:PostalAddress
            type:Organization
      name:Helmut Friess
      affiliation:
            name:Klinikum rechts der Isar, Technische Universität München
            address:
               name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
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      name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
      name:Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
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